MAGNETOENCEPHALOGRAPHY IN EPILEPSY

癫痫脑磁图检查

• 批准号: 3401420
• 负责人: William W. Sutherling
• 金额: $ 30.3万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3401420
• 关键词: biomagnetism; brain disorder diagnosis; brain electrical activity; brain mapping; computer simulation; congenital oral /facial /cranial defect; direct cortical response; electrocorticography; electrodes; electroencephalography; evoked potentials; human subject; human tissue; magnetic field; magnetic resonance imaging; magnetoencephalography; mathematical model; partial seizure; somesthetic sensory cortex

During the first year of the grant with a new 7-channel magnetometer we have made substantial progress in all 5 steps of the proposed research. We plan to complete the goals of the original 3 year research proposal within the 2 years awarded on the grant. We have: (1) modeled forward and inverse dipole solutions in MEG, EEG, and cortical EEG (ECoG) with goodness of fit measures and residuals; (2) modeled multiple moving dipole solutions in MEG; (3) localized the central fissure close to hand area of primary sensory cortex in 4 patients on MEG, EEG, and ECoG with moving dipole solutions, with localization errors of 4 to 6mm, verified by cortical stimulations; (4) recorded deep spikes on MEG; (5) mapped simultaneous, spontaneous MEG and ECoG of human interictal spikes; (6) verified MEG seizure localization within 1-1.5 cm by subdural recordings; (7) mapped simultaneous, spontaneous MEG and EEG of human partial seizures with dipolar patterns; and (8) implemented a 48 channel recording system for simultaneous MEG, EEG, and ECoG recording. During the final second year of the grant, we will complete all steps, mapping and localizing the center interictal spikes and seizures in multichannel MEG, EEG, and ECoG. The temporary use of a magnetically shielded room has been essential to systematic completion of steps 4 and 5. In this renewal, we propose extension of the research to more accurate epileptic source identification in a magnetically shielded room. The severe magnetic noise which has developed in our unshielded hospital environment markedly limits the natural extension of research into promising areas, developed at Reed and proved capable of study. A multichannel magnetometer in a shielded environment is essential to the systematic study of the spatiotemporal structure of simultaneous MEG, EEG and cortical EEG of the spontaneous and averaged human interictal spike and seizure. In this renewal, we request funds for salary for essential personnel and for a magnetically shielded room which we have tested during the last 2 months and the essential nature of which is shown in the progress report. We want to continue systematic investigation of MEG, comparison of MEG and EEG, and integrated use of their complementary information to identify intracranial current sources in a large number of patients to achieve statistical numbers. Funds are requested for essential consulting collaboration with Dr. Terrance Darcey of Yale University School of Medicine, New Haven, Connecticut, in MEG, EEG, and ECoG modeling. We have already obtained: (1) 39% of required funds for new equipment and (2) 36% of required funds for personnel from other sources, and those are exhausted. The funds requested here are the minimum essential to continue systematic research of the magnetic field of the human epileptic focus in a statistical number of patients.

在第一年的赠款与一个新的7通道 我们在所有5个步骤中取得了实质性进展， 拟议的研究。 我们计划完成 原3年研究计划书在2年内批出， 格兰特. 我们有：（1）模型化的正、逆偶极子解 在MEG、EEG和皮层EEG（ECoG）中，采用拟合优度测量 （2）模拟脑磁图中的多个运动偶极子解; (3)将中央裂定位在原发性基底节的手区附近 4例患者感觉皮层的MEG、EEG和ECoG与运动有关 偶极解的定位误差为4 ~ 6 mm （4）记录脑磁图上的深棘波;（5） 人发作间期同步、自发脑磁图和皮层脑电图 尖峰;（6）验证MEG癫痫发作定位在1-1.5 cm范围内， 硬膜下记录;（7）映射的同时，自发MEG和 人类部分性癫痫发作的脑电图与偶极模式;和（8） 实现了用于同时MEG的48通道记录系统， EEG和ECoG记录。 在最后的第二年， 格兰特，我们将完成所有步骤，映射和本地化 多通道MEG、EEG和 皮层脑电图 暂时使用磁屏蔽室 对系统完成步骤4和5至关重要。 在这 更新，我们建议扩展研究，以更准确地 癫痫源识别在磁屏蔽室。 在我们的无屏蔽环境中产生的严重的磁噪声 医院环境明显限制了 研究有前途的领域，在里德开发，并证明有能力 学习。 屏蔽环境中的多通道磁力仪 是系统研究时空 脑磁图、脑电图和皮层脑电图的同步结构 自发和平均人类发作间期峰和癫痫发作。 在 这次续约，我们要求资金支付必要人员的工资， 而对于我们测试过的磁屏蔽室， 过去2个月，其基本性质见 进度报告。 我们要继续系统地调查 脑磁图、脑磁图与脑电图的比较及其综合应用 识别颅内电流源的补充信息 在大量的患者中实现统计数字。 要求提供资金，用于与博士进行必要的咨询合作。 来自纽黑文耶鲁大学医学院的Terrance Darcey， 康涅狄格州，在MEG，EEG和ECoG建模。 我们已经 获得：（1）新设备所需资金的39%;（2）36% 其他来源的人员所需的资金，这些是 耗尽. 这里要求的资金是最低限度的必要， 继续对人类磁场进行系统研究 癫痫病灶的患者统计数字。