MAGNETOENCEPHALOGRAM IN EPILESPY

癫痫脑磁图

• 批准号: 2263979
• 负责人: William W. Sutherling
• 金额: $ 16.13万
• 依托单位: GOOD SAMARITAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 1995-04-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2263979
• 关键词: brain disorder diagnosis; brain electrical activity; brain mapping; clinical biomedical equipment; computer simulation; electrocorticography; electrodes; electroencephalography; epilepsy; evoked potentials; human subject; magnetic resonance imaging; magnetoencephalography; mathematical model; model design /development; noninvasive diagnosis; partial seizure; postmortem; somesthetic sensory cortex

We have completed 3/5ths of the goals of the grant, making progress in all 5 steps of the research. We will complete the major goals of the grant within the time awarded on the grant. The 7 channel magnetometer, shielded room, and PPI are working beyond expectations in the same fiducial coordinates for MEG, EEG, ECoG, and MR scans using PPI resolution of < 1mm, excellent signal-to-noise ratios for spontaneous spikes and seizures, and adequate spatial coverage of the special coplanar wide gradiometer hexagon to capture a phase reversal and null point of spontaneous seizures and spikes during simultaneous ECoG. We have studied a large number of events in more patients. We have determined that a comprehensive study of a each patient improves localization accuracy and comparisons and that larger patient sample size is necessary to test further hypotheses. We will extend research in each step of the 5 step approach. We propose to study a larger number of patients with complete studies of MEG, EEG, and ECoG for implanted dipoles, evoked responses, and spontaneous spikes and seizures in each patient. We want to investigate propagation patterns of spikes and seizures for more accurate quantification of epileptic areas, of potential importance for surgical treatment. We plan to compare 7 MEG + 60 EEG channels to 37 MEG + 60 EEG channels to determine the added value of a large array MEG system and an upgrade to first derivative gradiometers. We believe the combination of 7 MEG and 60 EEG channels can answer important questions similar to a larger array MEG system. We will use and improve multiple fixed dipole solutions in MEG, EEG, and ECoG with MR information in individual patients to improve model estimates, an EEG 4 shell model with measurements of conductivities in individual patients, a basic finite element model, localizations of digit rostrocaudal bands, and localizations of spontaneous partial seizures in simultaneous MEG+EEG and MEG+ECoG. We will make a detailed comparison of spatiotemporal structure from multiple source modeling between the better understood evoked response and the less understood spike and seizure. We request no new equipment. We request funding for maintenance costs for the 7 channel system, salary for the principal investigator and a technologist, travel for consultants on modeling, and supplies including liquid helium. The funds requested here are the minimum essential to continue systematic research of physical interpretation of the magnetic field and scalp and cortical electric field in a statistical number of patients to describe non-invasively the spatiotemporal structure of medically intractable partial seizures for presurgical localization.

我们已经完成了拨款目标的 3/5，使得 研究的所有 5 个步骤均取得进展。 我们将完成主要目标 在授予补助金的时间内获得补助金。 7通道 磁力计、屏蔽室和 PPI 的工作超出预期 使用 PPI 进行 MEG、EEG、ECoG 和 MR 扫描的相同基准坐标 分辨率 < 1mm，自发信号的信噪比极佳 尖峰和癫痫发作，以及特殊共面的足够空间覆盖 宽梯度仪六边形捕获相位反转和零点 同时 ECoG 期间出现自发性癫痫发作和尖峰。 我们研究过 大量事件发生在更多患者身上。 我们确定了一个 对每位患者的全面研究提高了定位准确性 比较，并且需要更大的患者样本量来测试 进一步的假设。 我们将在 5 个步骤中的每一步中扩展研究 方法。 我们建议研究更多具有完全症状的患者 对植入偶极子、诱发反应和 ECoG 的 MEG、EEG 和 ECoG 研究 每个患者都会出现自发性尖峰和癫痫发作。 我们想要调查 尖峰和癫痫发作的传播模式更加准确 癫痫区域的量化，对手术具有潜在的重要性 治疗。 我们计划将 7 MEG + 60 EEG 通道与 37 MEG + 60 EEG 通道进行比较 确定大型阵列 MEG 系统和 升级到一阶导数梯度计。 我们相信结合 7 个 MEG 和 60 个 EEG 通道可以回答类似于 更大的阵列MEG系统。 我们将使用和改进多个固定偶极子 MEG、EEG 和 ECoG 解决方案以及个体患者的 MR 信息 为了改进模型估计，EEG 4 壳模型的测量值为 个体患者的电导率，基本的有限元模型， 数字头尾带的定位和自发的定位 同时 MEG+EEG 和 MEG+ECoG 中的部分性癫痫发作。 我们将制作一个 多源时空结构的详细比较 在更好理解的诱发反应和较少理解的诱发反应之间建立模型 了解尖峰和癫痫发作。 我们不要求新设备。 我们请求维护资金 7个通道系统的费用、首席研究员的工资和 技术专家、建模顾问的差旅以及用品，包括 液氦。 这里要求的资金是最低限度的必要资金 继续系统研究磁的物理解释 场和头皮及皮层电场统计数量 患者以非侵入性的方式描述时空结构 用于术前定位的医疗难治性部分性癫痫发作。