Magnetoencephalogram in Epilepsy

癫痫脑磁图

• 批准号: 6472535
• 负责人: William W. Sutherling
• 金额: $ 35.96万
• 依托单位: HUNTINGTON MEDICAL RESEARCH INSTITUTES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6472535
• 关键词: action potentials; biomedical equipment development; brain disorder diagnosis; brain electrical activity; brain mapping; clinical biomedical equipment; clinical research; computational neuroscience; computer program /software; computer simulation; electrocorticography; electroencephalography; epilepsy; evoked potentials; human subject; magnetic resonance imaging; magnetoencephalography; neocortex; noninvasive diagnosis; partial seizure; preoperative state

DESCRIPTION: (Verbatim from applicant's abstract) We will measure simultaneous MEG and chronic ECoG co-registered in MRI in pre-surgical patients with intractable partial epilepsy during afterdischarges, inter-ictal spikes, and, in some patients, seizures. We will use our newly installed whole cortex 68-channel neuromagnetometer and 64 EEG channels. We will compare the localization specificity and detection sensitivity of the two fields and investigate new methods of improving the MEG by studying the same event from the cortex. We will apply realistic models of the source and of the volume conductor in BrainStorm and Curry in collaboration with Drs. Mosher, Leahy, and Baillet. We will compare these new models to the standard single dipole model used clinically. We will study MEG and EEG and attempt their fusion. We will study the characteristics of live skull. We will test if realistic models add useful additional information. We will test how MEG and source analysis can enhance present noninvasive standard epilepsy pre-surgical evaluations to localize the epileptogenic zone. We will map the outer borders of hand cortex to allow more precise maps of essential areas for surgical planning. We purchased the neuromagnetometer with a shared instrumentation grant and we will make our results and lab available to several other collaborators, to enhance their research in, for instance, language and to ensure maximum utility from this costly NIH equipment.

描述：（来自申请人摘要的逐字）我们将同时测量 MEG和慢性ECoG在术前MRI中共同记录的患者 在后放电、发作间期棘波期间顽固性部分性癫痫， 在一些病人中，癫痫发作。我们将使用我们新安装的整个皮层 68-通道神经磁力计和64个EEG通道。我们将比较 两个视野的定位特异性和检测灵敏度， 研究通过研究同一事件来改善MEG的新方法， 大脑皮层 我们将应用源和体积导体的真实模型， BrainStorm和咖喱与Mosher、Leahy和Baillet博士合作。我们 我将把这些新模型与标准的单偶极子模型进行比较 临床上我们将研究脑磁图和脑电图，并尝试他们的融合。我们将研究 活头骨的特征。我们将测试是否现实的模型添加有用的 补充资料。 我们将测试MEG和源分析如何增强目前的非侵入性 标准癫痫术前评估以定位致痫区。 我们将绘制手部皮层的外部边界，以便更精确地绘制 手术计划的重要领域。我们购买了神经磁力计， 一个共享的仪器补助金，我们将使我们的结果和实验室可用 其他几个合作者，以加强他们的研究，例如， 语言，并确保从这个昂贵的NIH设备的最大效用。