Magnetoencephalogram in Epilepsy

描述：(逐字摘自申请者摘要)我们将同时测量 术前脑磁图和慢性皮层脑电图在MRI中的联合注册 顽固性部分性癫痫后放电，发作间歇性棘波， 在一些病人中，癫痫发作。我们将使用新安装的整个皮质 68导联神经磁力仪和脑电导联。我们将比较 这两个领域的定位特异性和检测敏感性 通过研究同一事件来研究改善脑磁图的新方法 大脑皮层。 我们将在中应用声源和体积导体的真实模型 头脑风暴和咖喱与博士Mosher，Leahy和Baillet合作。我们 我会将这些新模型与使用的标准单偶极子模型进行比较 从临床上看。我们将研究脑磁图和脑电，并尝试它们的融合。我们会研究 活体头骨的特点。我们将测试真实模型是否添加了有用的 其他信息。 我们将测试脑磁图和来源分析如何增强目前的非侵入性 标准的癫痫术前评估，以定位致痫区域。 我们将绘制手部皮质的外部边界，以便更精确地绘制 外科手术计划的基本领域。我们购买神经磁强计是用 一笔共享的仪器拨款，我们将提供我们的结果和实验室 给其他几个合作者，以加强他们的研究，例如， 并确保最大限度地利用这台昂贵的NIH设备。

DESCRIPTION: (Verbatim from applicant's abstract) We will measure simultaneous MEG and chronic ECoG co-registered in MRI in pre-surgical patients with intractable partial epilepsy during afterdischarges, inter-ictal spikes, and, in some patients, seizures. We will use our newly installed whole cortex 68-channel neuromagnetometer and 64 EEG channels. We will compare the localization specificity and detection sensitivity of the two fields and investigate new methods of improving the MEG by studying the same event from the cortex. We will apply realistic models of the source and of the volume conductor in BrainStorm and Curry in collaboration with Drs. Mosher, Leahy, and Baillet. We will compare these new models to the standard single dipole model used clinically. We will study MEG and EEG and attempt their fusion. We will study the characteristics of live skull. We will test if realistic models add useful additional information. We will test how MEG and source analysis can enhance present noninvasive standard epilepsy pre-surgical evaluations to localize the epileptogenic zone. We will map the outer borders of hand cortex to allow more precise maps of essential areas for surgical planning. We purchased the neuromagnetometer with a shared instrumentation grant and we will make our results and lab available to several other collaborators, to enhance their research in, for instance, language and to ensure maximum utility from this costly NIH equipment.