MAGNETOENCEPHALOGRAM IN EPILEPSY

癫痫脑磁图

• 批准号: 2379602
• 负责人: William W. Sutherling
• 金额: $ 12.68万
• 依托单位: GOOD SAMARITAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2379602
• 关键词: action potentials; biomedical equipment development; brain disorder diagnosis; brain electrical activity; brain mapping; clinical biomedical equipment; computational neuroscience; computer simulation; electrocorticography; electroencephalography; epilepsy; evoked potentials; human subject; magnetic resonance imaging; magnetoencephalography; model design /development; noninvasive diagnosis; partial seizure

We have transferred the grant to the Neurosciences Institute at the Hospital for the Good Samaritan which has heavily supported our research resulting in larger patient volume and higher productivity. We will complete the major goals of the grant within the time awarded on the grant. The 7 channel magnetometer, shielded room, and PPI are working well in our new larger laboratory with coregistration of MEG, EEG, ECoG, and MRI data with 1mm resolution, excellent signal-to-noise ratios for spikes and seizures, and adequate spatial coverage of the coplanar MEG array to capture a phase reversal and null point of spontaneous seizures and spikes during simultaneous 128 channel ECoG. We have studied a large number of events in more patients and plan to study large populations. We have determined that a comprehensive study of each patient improves localization accuracy and comparisons and that larger patient sample size is necessary to test our hypotheses. We will extend research in each step of the 5 step approach. We propose to study a larger number of patients with complete studies of MEG, EEG, and ECoG for implanted dipoles, evoked responses, and spontaneous spikes and spontaneous and induced seizures in each patient. We want to investigate propagation patterns of spikes and seizures for more accurate quantification of epileptic areas, of potential importance for surgical treatment. We will continue to compare 7 MEG + 128 EEG channels to 37 MEG + 128 EEG channels to determine the added value of a large array MEG system. We believe the combination of 7 MEG and 60 EEG channels can answer important questions similar to a larger array MEG system. We will use and improve multiple fixed dipole solutions in MEG, EEG, and ECoG with MR information in individual patients, an EEG 4 shell model with measurements of conductivities in individual patients, our finite element model, localizations of digit rostrocaudal bands and the different cortices of posterior tibial nerve , and localizations of spontaneous and induced partial seizures in simultaneous MEG+EEG and MEG+ECoG. We will make a detailed comparison of spatiotemporal structure from multiple source modeling between the better understood evoked response and the less understood spike and seizure.

我们已经将拨款转移到了神经科学研究所， 大力支持我们研究的好撒玛利亚人医院 从而导致更大的患者量和更高的生产率。我们将 在授予的时间内完成补助金的主要目标， 格兰特. 7通道磁力仪、屏蔽室和PPI工作正常 在我们新的更大的实验室，MEG，EEG，ECoG和 MRI数据分辨率为1mm，尖峰信号的信噪比极佳 和癫痫发作，以及共面MEG阵列的足够空间覆盖， 捕获自发性癫痫发作和棘波的相位反转和零点 同时进行128通道ECoG期间。我们研究了大量的 更多患者的事件，并计划研究大规模人群。我们有 确定对每位患者进行全面研究， 定位准确性和比较以及较大的患者样本量 是检验我们假设的必要条件我们将在每一步进行研究 5步方法。我们建议研究更多的患者 通过对植入偶极子的MEG、EEG和ECoG的完整研究，诱发 反应，自发性尖峰和自发性和诱导癫痫发作， 每一个病人。我们想研究尖峰信号的传播模式， 癫痫发作，以便更准确地量化癫痫区域， 手术治疗的重要性。我们将继续比较7 MEG + 128 EEG通道到37 MEG + 128 EEG通道，以确定 大阵列脑磁图系统。我们认为7脑磁图和60脑电图的结合 通道可以回答类似于更大阵列MEG的重要问题 系统我们将在MEG中使用和改进多个固定偶极子解决方案， EEG和ECoG与个别患者的MR信息，EEG 4外壳 我们的模型测量了个体患者的电导率， 有限元模型，手指喙尾带的定位和 胫后神经的不同皮质，以及 同时MEG+EEG中的自发和诱导部分性癫痫发作， 脑磁图+皮层脑电图。我们将对时空结构进行详细的比较 从多源模型之间更好地理解诱发 反应和不太了解的尖峰和癫痫发作。