PHYSIOLOGICAL BASES OF MAGNETOENCEPHALOGRAPHY
脑磁图的生理学基础
基本信息
- 批准号:3402012
- 负责人:
- 金额:$ 14.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1985
- 资助国家:美国
- 起止时间:1985-03-01 至 1991-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
As in our previous application, the general aim of this proposal is
to study the physiological basis of magnetoencephalograms
(MEGs) in order to help interpret non-invasively obtained human
MEGs. Continuing and extending our previous work, we propose
(1) to elucidate the nature of the currents that may give rise to
the MEG, (2) to characterize the relationship between the MEG
and its underlying currents in different structures of a mammalian
brain and (3) to characterize the magnetic field associated with
spreading depression (SD) and anoxia. Specifically, we will
determine the relative contributions intraneuronal, extracellular
and glial currents to the MEG in the isolated turtle cerebellum by,
first of all, constructing a mathematical model that incorporates
various ionic conductances in a model neuron, K+-mediated
currents in the ependymal glia and ionic currents in the
extracellular space and them comparing its predictions to the
MEGs data to be obtained in a series of experiments in which Na-,
K- and Ca-conductances and (K+) are manipulated. We will also
evaluate the relative the contributions to the MEG Na- and Ca-
conductances in the neuronal soma and dendrites of isolated turtle
cerebellum and guinea-pig cerebellar slice by manipulating ionic
composition of the bathing medium and blocking one type of
conductance and then measuring the MEG due to these
conductances separately. Issue two will be addressed by
comparing the MEG-current relationships in the slice preparations
of the primary sensorimotor cortex and its thalamocortical
radiation fibers, hippocampus, cerebellum and thalamus of the
guinea pig. Slice preparations are chosen, for they enable us to
orient the principal core conductors horizontally in the bathing
medium medium just below the detector in order to maximize the
MEG as to these conductors. Regarding SD and anoxia, our work
indicates that a strong magnetic field is produced during the
initial stage of SD in turtle cerebellum unlike the extracellular
potential which often outlasts the MEG. We will test whether this
difference temporal waveform is due to a strong transcortical
current in the initiation stage of and whether such a strong
current is produced during the anoxic depolarization as suggested
by various lines of indirect evidence. Also the origin of dc
potential during and anoxia will be studied by evaluating roles of
the spatial buffer mechanism and Nernst potential in producing
such a potential. Furthermore, the MEG associated with the
transversal current at the propagating wavefront of SD will be
measured. These results taken together will be used to interpret
the MEG to be measured from intact during SD and anoxia.
与我们之前的应用程序一样,此提案的总体目标是
脑磁图的生理学基础研究
(Megs)以帮助解释非侵入性获得的人类
梅格斯。继续和扩展我们以前的工作,我们建议
(一)澄清可能产生的水流的性质
脑磁图,(2)刻画脑磁图与脑磁图的关系
以及它在哺乳动物不同结构中的潜在电流
大脑和(3)表征与之相关的磁场
弥漫性抑郁(SD)和缺氧。具体来说,我们将
确定神经元内、细胞外的相对贡献
以及神经胶质细胞电流到隔离的海龟小脑的脑磁图,
首先,构建一个包含了
K+介导的模型神经元中的各种离子电导
室管膜神经胶质细胞的电流和脑室管膜上的离子电流
细胞外空间,并将其预测与
Megs数据将通过一系列实验获得,在这些实验中,Na-,
K-、Ca-电导和(K+)是可操纵的。我们还将
对脑磁图中Na~-和Ca~-的相对贡献进行评价
离体龟神经元胞体和树突的电导
离子推拿法制作小脑及豚鼠小脑切片
沐浴介质的组成和阻隔一种类型的
电导,然后测量脑磁图,由于这些
不同的电导。第二个问题将通过以下方式解决
切片制备中脑磁图电流关系的比较
初级感觉运动皮质及其丘脑皮质
大鼠海马体、小脑和丘脑的辐射纤维
豚鼠。选择片剂是因为它们使我们能够
在浴池中水平定向主芯导线
在探测器正下方的介质介质,以便最大化
梅格对这些导体的看法。关于SD和缺氧,我们的工作是
表明在太阳活动过程中产生了强磁场
甲鱼小脑早期SD不同于细胞外
潜质往往比梅格更持久。我们将测试这是否
不同的时间波形是由于强烈的经皮质
目前处于起步阶段,是否有如此强劲的
按照建议,在缺氧去极化过程中会产生电流
通过各种间接证据。也是DC的起源
潜在的期间和缺氧将研究通过评估的作用
生产中的空间缓冲机制和能斯特势
这样的潜力。此外,与脑磁图相关的脑磁图
在SD传播波前的横向电流将是
量过了。这些结果加在一起将被用来解释
脑磁图在SD和缺氧期间以完整的方式测量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Yoshio Okada其他文献
Yoshio Okada的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Yoshio Okada', 18)}}的其他基金
COBRE: UNM: ADMINISTRATIVE/INFRASTRUCTURE CORE
COBRE:UNM:行政/基础设施核心
- 批准号:
7959365 - 财政年份:2009
- 资助金额:
$ 14.45万 - 项目类别:
COBRE: UNM: ADMINISTRATIVE/INFRASTRUCTURE CORE
COBRE:UNM:行政/基础设施核心
- 批准号:
7720118 - 财政年份:2008
- 资助金额:
$ 14.45万 - 项目类别:
Cortical current imaging in human infants with babySQUID
使用babySQUID 对人类婴儿进行皮质电流成像
- 批准号:
7186020 - 财政年份:2007
- 资助金额:
$ 14.45万 - 项目类别:
COBRE: UNM: ADMINISTRATIVE/INFRASTRUCTURE CORE
COBRE:UNM:行政/基础设施核心
- 批准号:
7609845 - 财政年份:2007
- 资助金额:
$ 14.45万 - 项目类别:
Cortical current imaging in human infants with babySQUID
使用babySQUID 对人类婴儿进行皮质电流成像
- 批准号:
7433288 - 财政年份:2007
- 资助金额:
$ 14.45万 - 项目类别:
COBRE: UNM: ADMINISTRATIVE/INFRASTRUCTURE CORE
COBRE:UNM:行政/基础设施核心
- 批准号:
7381214 - 财政年份:2006
- 资助金额:
$ 14.45万 - 项目类别:
COBRE: UNM: ADMINISTRATIVE/INFRASTRUCTURE CORE
COBRE:UNM:行政/基础设施核心
- 批准号:
7170388 - 财政年份:2005
- 资助金额:
$ 14.45万 - 项目类别:
COBRE: UNM: ADMINISTRATIVE/INFRASTRUCTURE CORE
COBRE:UNM:行政/基础设施核心
- 批准号:
7011829 - 财政年份:2004
- 资助金额:
$ 14.45万 - 项目类别:
ADMIN: PROGRAM IN CNS PATHOPHYSIOLOGY RESEARCH
管理员:中枢神经系统病理生理学研究项目
- 批准号:
6569299 - 财政年份:2002
- 资助金额:
$ 14.45万 - 项目类别:
相似海外基金
Neurotechnology industry meeting science: an industry research symposium at the 19th international conference on biomagnetism
神经技术行业遇见科学:第十九届国际生物磁学会议行业研究研讨会
- 批准号:
468990-2014 - 财政年份:2014
- 资助金额:
$ 14.45万 - 项目类别:
Regional Office Discretionary Funds