VASOPRESSIN AND FLANK MARKING BEHAVIOR

加压素和侧翼标记行为

• 批准号: 3407191
• 负责人: Craig F Ferris
• 金额: $ 14.82万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3407191
• 关键词: afferent nerve; aggression; animal communication behavior; behavior test; brain mapping; chemical structure function; efferent nerve; ethology; experimental brain lesion; histochemistry /cytochemistry; hormone regulation /control mechanism; immunochemistry; kainate; microinjections; neuroendocrine system; neuropsychology; neurotoxins; neurotransmitters; olfactions; peptide hormone analog; preoptic areas; sex behavior; social behavior; social dominance; vasopressins

Flank marking, a form of olfactory communication in Golden hamsters (Mesocricetus auratus) is dependent upon a vasopressin-sensitive pathway in the medial preoptic area (MPOA) of the hypothalamus. Vasopressin (VP) microinjected into a discrete site of the MPOA reliably elicits intense bouts of flank marking and an antagonist to vasopressin injected into the same site inhibits flank marking induced by microinjection of VP or the odors of other hamsters. Studies have been proposed to define the afferent and efferent connections of the area within the MPOA controlling flank marking behavior by horseradish peroxidase histochemistry. Once identified, these sensory and motor connections will be lesioned to determine their relevance in the expression of flank marking. The concentration of VP within the effective site of the MPOA will be determined by chromatographic and immunochemical methods and the binding characteristics of VP within this site will be determined by Scatchard analysis. Various analogs and metabolites of VP will be microinjected into the MPOA to study the structure-activity relationship between VP and flank marking. Finally, a series of studies will be conducted to investigate the function of flank marking behavior in specific social situations (i.e. aggressive and reproductive interactions). In summary, vasopressin-dependent flank marking in the MPOA provides an excellent model system for studying the neuroanatomy and chemistry involved in the organization and expression of a complex communicative behavior. Defining the anatomical and neurochemical bases of a mammalian behavior should eventually lead to a better understanding of normal and abnormal human behavior.

侧面标记，金仓鼠的一种嗅觉交流形式 （中核auratus）取决于加压素敏感的途径 下丘脑的内侧前区（MPOA）。 加压素（VP） 微观注射到MPOA的离散位点可靠地引起强烈的引起 侧面标记和对加压素注入加压素的拮抗剂 同一位点抑制了VP的显微注射引起的侧面标记 其他仓鼠的气味。 已经提出了研究来定义传入 MPOA控制侧面的区域的传出连接 标记辣根过氧化物酶组织化学的行为。 一次 确定，这些感官和电机连接将被病变为 确定它们在侧面标记表达中的相关性。 这 MPOA有效部位内VP的浓度将为 通过色谱和免疫化学方法和结合确定 该站点内VP的特征将由Scatchard确定 分析。 VP的各种类似物和代谢产物将被微注射到 研究VP与侧面之间的结构活性关系的MPOA 标记。 最后，将进行一系列研究以研究 侧面标记行为在特定社交情况下的功能（即 侵略性和生殖相互作用）。 总之， MPOA中依赖加压素的侧面标记提供了出色的模型 研究参与的神经解剖学和化学的系统 复杂的交流行为的组织和表达。 定义 哺乳动物行为的解剖学和神经化学基础应 最终导致对正常和异常人的更好理解 行为。