FUNCTIONAL ANALYSIS OF CEREBELLAR INTERPOSITUS NUCLEUS

这项拨款中提议的工作有一个长期目标，即理解 能让我们控制运动的神经系统。无论是解剖学还是 生理学将被用来研究以下基本问题 小脑功能。解剖学研究将利用最近的 引进技术(标记凝集素的运输和演示) 它们功能强大且高效，可同时跟踪输入和 神经系统小区域的输出连接。的区域 参与控制特定肢体运动的小脑将被定义 精确度比目前还高。肢体特定部分 猫和猴的大细胞红核和间位核 将通过电生理技术进行鉴定并注射 HRP标记的小麦胚凝集素。结合解剖学研究， 相同区域的功能属性将通过 慢性单单位记录在行为猴中的应用。录音将 在受试者执行各种训练有素的运动任务时进行， 神经信号将与特定的运动参数相关。 通过这种方式，对小脑在正常大脑中所起的作用的理解 行动将会有所收获。一些基本的问题，比如小脑是否 在纠错或初始电机编程中起作用，以及用什么 什么样的“语言”才能实现它的运动功能就会得到回答。 所获得的信息将对研究、诊断和 对影响运动的病理状态的治疗。的最新进展 生物技术使研究人员试图模仿神经运动控制 用于假肢目的。理解神经信号涉及到的 运动控制是指导和评估可行性的前提 不同的临床方法。

The work proposed in this grant has the long term goal of understanding the neural systems which allow us to control movement. Both anatomy and physiology will be used to investigate fundamental questions concerning cerebellar functions. The anatomical studies will make use of recently introduced techniques (transport and demonstration of labeled lectins) which are powerful and efficient for simultaneously tracing input and output connections of small areas of the nervous system. Areas of the cerebellum involved in controlling specific limb movements will be defined with more precision than has yet been accomplished. Limb specific portions of the magnocellular red nucleus and interpositus nucleus of cat and monkey will be identified with electrophysiological techniques and injected with HRP labeled wheat germ lectin. In combination with the anatomical studies, the functional properties of the same areas will be determined through the use of chronic single unit recording in behaving monkeys. Recordings will be made while the subjects perform a variety of highly trained motor tasks, and the neural signals will be related to specific parameters of movement. In this way, an understanding of the role the cerebellum plays in normal movements will be gained. Basic questions such as whether the cerebellum is acting in error correction or initital motor programming and with what sort of "language" does it carry out its motor functions will be answered. The information gained will be valuable in the study, diagnosis and treatment of pathological states affecting movement. Recent advances in biotechnology have led researchers to attempt to mimic neural motor control for prosthetic purposes. Understanding the neural signals involved in motor control is a prerequisite for guiding and evaluating the feasibility of various clinical approaches.