MOVEMENT CONTROL BY A CEREBELLAR CIRCUIT

这项拨款中提出的工作是一项研究计划的一部分 旨在理解运动的控制。 我们的一 最常见和最重要的行动是伸出手来，抓住一个 object. 这是一项复杂的任务，涉及以下内容的整合 感觉信息与整个肢体的运动控制，但 在正常情况下，我们毫不费力地完成这项任务。 我 认为小脑在整合和 生成电机命令以实现这种控制，并且 建议结合行为，生理和解剖 了解小脑活动的技术。 具体来说， 将神经放电与协调运动的参数联系起来。 这些研究的结果将有助于解开控制代码（或 运动“语言”），神经系统用来使 动作 我还会用现代解剖技术 特别是涉及运动控制神经结构。 通过 发现神经系统的相互关联的元素，我们将 能够追踪神经系统中的信息流， 感觉输入被转换成运动输出。 理解 小脑中发生的处理将是一个重大的科学问题， 进步。 获得的信息将对科学家有帮助 试图理解和纠正病理状态 影响我们的控制运动 我们试图返回残疾人 积极生活的人还处于婴儿期。 即使是微小的进步 对他们的生活有很大的帮助

The work proposed in this grant is part of a research program directed at understanding the control of movement. One of our most common and vital actions is to reach out and grasp an object. It is a complicated task involving the integration of sensory information with motor control of the entire limb, yet under normal circumstances we perform the task effortlessly. I believe that the cerebellum plays a major role in integrating and generating motor commands to achieve such control, and this proposal combines behavioral, physiological and anatomical techniques to understand cerebellar action. Specifically I will relate neural discharge to parameters of coordinated movements. The results of these studies will help unravel the control codes (or motor "language") that the nervous system uses to make movements. I will also use modern anatomical techniques to specifically relate neural structures involved in motor control. By discovering interrelated elements of the nervous system we will be able to trace information flow through the nervous system as sensory input is converted to motor output. Understanding processing occurring in the cerebellum will be a major scientific advancement. The information gained will be of help to scientists attempting to understand and correct pathological states affecting our control movement. Our attempts to return disabled people to an active life are in their infancy. Even small advances in our knowledge could be large advances in their lives.