MOVEMENT CONTROL BY A CEREBELLAR CIRCUIT

这项拨款建议的工作是一项研究计划的一部分。 旨在理解运动的控制。我们的一个人 最常见和最重要的行动是伸出手，抓住一个 对象。这是一项复杂的任务，涉及到 感觉信息和整个肢体的运动控制，但 在正常情况下，我们毫不费力地完成这项任务。我 我相信小脑在整合和 产生电机命令以实现这种控制，并且这 建议将行为学、生理学和解剖学结合起来 了解小脑活动的技巧。具体来说，我会 将神经放电与协调运动的参数联系起来。 这些研究的结果将有助于解开控制代码(或 运动“语言”)，神经系统用来制造 动静。我还将使用现代解剖学技术 具体地说，就是涉及运动控制的神经结构。通过 发现神经系统的相互关联的元素，我们将 能够追踪通过神经系统的信息流 感觉输入被转换为运动输出。理解 发生在小脑的处理将是一个主要的科学 进步。所获得的信息将对科学家有所帮助 试图理解和纠正病理状态 影响我们的控制运动。我们试图将残疾人送回家 喜欢积极生活的人还处于婴儿期。即使是很小的进步 据我们所知，他们的生活可能会有很大的进步。

The work proposed in this grant is part of a research program directed at understanding the control of movement. One of our most common and vital actions is to reach out and grasp an object. It is a complicated task involving the integration of sensory information with motor control of the entire limb, yet under normal circumstances we perform the task effortlessly. I believe that the cerebellum plays a major role in integrating and generating motor commands to achieve such control, and this proposal combines behavioral, physiological and anatomical techniques to understand cerebellar action. Specifically I will relate neural discharge to parameters of coordinated movements. The results of these studies will help unravel the control codes (or motor "language") that the nervous system uses to make movements. I will also use modern anatomical techniques to specifically relate neural structures involved in motor control. By discovering interrelated elements of the nervous system we will be able to trace information flow through the nervous system as sensory input is converted to motor output. Understanding processing occurring in the cerebellum will be a major scientific advancement. The information gained will be of help to scientists attempting to understand and correct pathological states affecting our control movement. Our attempts to return disabled people to an active life are in their infancy. Even small advances in our knowledge could be large advances in their lives.