ORGANOTOPIC SPECIFICITY IN AUTONOMIC PATHWAYS

大脑是如何控制单个外周内脏器官的？ Katz和Karten [49-56]已经证明了精确的 周围内脏器官在亚核中的器官定位表示 的nuc。孤束和迷走神经运动核 （nTs-DMX）。 每一个的中枢传入和传出连接是什么 nTs和DMX的器官特异性亚核？ 是否有单独的解剖结构 丘系调节肺、胃肠道、胰腺和心血管 nTs-DMX和大脑其他区域之间的系统，例如 下丘脑？ 传入和传出中枢的不同联系 nTs-DMX的器官特异性亚核的研究将使用 组织学方法，包括ARG nTs-DMX是名副其实的 外源性和内源性来源的各种肽/递质。 包括SP、CCK、ENK、VIP、NT、DA、NE、5-HT、GAD/GABA和CAT亚类。 初步研究揭示了它们在器官中的差异分布， nTs-DMX的特性。 它们的起源、定位和个体发育 将研究化学上不同的输入。 这些 实验将有助于阐明神经元的潜在机制， 下丘脑和生化物质对各个内脏的调节 和nTs-DMX的药理学组织。

How are individual peripheral visceral organs controlled by the brain? Katz and Karten [49-56] have demonstrated the existence of a precise organotopic representation of the peripheral visceral organs in subnuclei of the nuc. tractus solitarius and the motor nucleus of the vagus (nTs-DMX). What are the central afferent and efferent connections of each organ specific subnucleus of nTs and DMX? Are there separate anatomical lemnisci for regulation of pulmonary, GI, pancreatic and cardoivascular systems between nTs-DMX and other regions of the brain, such as the hypothalamus? The differential afferent and efferent central connections of organ specific subnuclei of the nTs-DMX will be studied using histological methods, including ARG nTs-DMX is veritable storehouse of various peptides/transmitters of both extrinsic and intrinsic origin. Including SP, CCK, ENK, VIP, NT, DA, NE, 5-HT, GAD/Gaba and subsets CAT. Pilot studies have revealed their differential distribution in organ specific of the nTs-DMX. The origin, localization and ontogeny of these immunohistochemically distinct inputs will be investigated. These experiments will help clarify the potential mechanisms of neuronal regulation of individual viscera by the hypothalamus and the boichemical and pharmacological organization of nTs-DMX.