DVR: VISUAL PATHWAYS AND THE ORIGINS OF NEOCORTEX

哺乳动物的新大脑皮层是复杂进化的产物 历史。关于感觉投射组织的研究 非哺乳动物脊椎动物的端脑已经证明 大脑皮质内等效神经元团的存在 端脑的背侧室脊(DVR)。这些“克隆人” 簇“可能对应于哺乳动物的单个片层 大脑皮层。“星团”之间连接的微电路 在技术分离通路内似乎对应于 纹外视路的层间组织 大脑皮层。对这一途径的进一步分析将有助于澄清 纹外系统在视觉表现中的作用。研究 将专注于在 DVR，DVR与新皮质的关系，以及可能的 脑室管膜下带在脑膜瘤个体发育中的作用 哺乳动物的新皮质。DVR可能对应于脑室下 哺乳动物发育中的新皮质中的狭窄带(SVZ)。 具体研究将包括： A.组织、组织化学和形态分析 鸟类DVR中顶盖分离通路的神经元。 B.分离丘脑通路和分离顶盖通路的相互关系。 C.生产鉴定“克隆性”的单抗 “团簇”及其可能与单叶的交叉反应 哺乳动物的大脑皮层。 E.研究哺乳动物SVZ作为一种可能的 背侧脑室脊的代表及其 参与新皮质的发育。 这些研究将澄清我们对这一角色的理解 视觉中的技术分离途径，人类进化的起源 哺乳动物的新皮质，以及正常和异常发育 哺乳动物新皮质个体发育中的事件。 可采用的方法包括路径追踪法、单细胞 填充、免疫组织化学、单抗和原位 杂交鉴定递质/多肽、受体和 参与组织和沟通的相关蛋白质 有两条路。

The mammalian neocortex is the product of a complex evolutionary history. Research on the organization of sensory projections to the telencephalon of nonmammalian vertebrates has demonstrated the presence of cortical equivalent "cluster" of neurons within the Dorsal Ventricular Ridge (DVR) of the telencephalon. These "clonal clusters" may correspond to individual laminae of the mammalian neocortex. The microcircuitry of connections between "clusters" within the tectofugal pathways appears to correspond to the interlaminar organization of extrastriate visual pathways of the neocortex. Further analysis of this pathway will help clarify the role of the extrastriate system in visual performance. Studies will concentrate on the organization of visual pathways within the DVR, the relationship of the DVR to the neocortex, and possible role of the subventricular zone of Stensaas in the ontogeny of neocortex in mammals. The DVR may correspond to the Subventricular Zone (SVZ) of Stensaas in the developing neocortex of mammals. Specific studies will include: A. Analysis of the organization, histochemistry and morphology of the neurons of the tectofugal pathway in the DVR of birds. B. Interrelationship of the thalamofugal and tectofugal pathways. C. Production of monoclonal antibodies to identify "clonal clusters" and their possible cross reactivity with single laminae of the neocortex of mammals. E. Investigate the role of the SVZ of mammals as a possible representative of the Dorsal Ventricular Ridge, and its participation in the development of neocortex. These studies will clarify our understanding of the role of tectofugal pathways in vision, the evolutionary origins of the mammalian neocortex, and both normal and abnormal developmental events in the ontogeny of the mammalian neocortex. Methods to be employed include pathway tracing methods, single cell filling, immunohistochemistry, monoclonal antibodies and in situ hybridization to identify the transmitters/peptides, receptors and related proteins mediating organization and communication in these two pathways.