DVR--VISUAL PATHWAYS AND THE ORIGINS OF NEOCORTEX

DVR--视觉通路和新皮质的起源

• 批准号: 2037258
• 负责人: HARVEY Jules KARTEN
• 金额: $ 27.78万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2037258
• 关键词: brain mapping; calcium indicator; chickens; developmental genetics; electron microscopy; embryo /fetus; evolution; histology; immunocytochemistry; in situ hybridization; laboratory rat; neocortex; neuroanatomy; neurotransmitter receptor; pigeons; sensorimotor system; species difference; squirrel; telencephalon; visual pathways

DESCRIPTION: The long term goals are to identify the origins of neocortex, and the nature of the cellular and molecular events that lead to its formation from precursors common to both mammals and reptiles/birds. In order to address these issues, they must be approached as two separate, but related, questions. 1. Can we identify populations in adult nonmammals homologous with populations of adult neocortical neurons of mammals? Are specific cells and pathways common to ancestors of both mammals and reptiles/birds? 2. What are the cellular and molecular events underlying the transformation of the forebrain from nonmammals to mammals? How have the components of the telencephalon been modified to produce the mammalian cortex?

描述：长期目标是确定 新皮层，以及导致这些细胞和分子事件的性质， 它的形成是由哺乳动物和 爬行动物/鸟类。为了解决这些问题，必须 这是两个独立但相关的问题。 1.我们能识别出 与成年非哺乳动物种群同源的成年非哺乳动物种群 哺乳动物的新皮层神经元 特定的细胞和通路是否常见 哺乳动物和爬行动物/鸟类的祖先吗2.有哪些 细胞和分子事件的转变， 从非哺乳动物到哺乳动物的前脑 如何让组件的 端脑被改造成了哺乳动物的大脑皮层