Model driven design of dense phase wet granulation processes

密相湿法制粒工艺的模型驱动设计

• 批准号: EP/K02566X/1
• 负责人: Agba Salman
• 金额: $ 31.81万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FK02566X%2F1
• 关键词: Model; driven; design; dense; phase

Wet granulation is the process of using a liquid binder to form well structured and well behaved granules from difficult to handle fine powders. Granulation allows the development of structured particulate products with defined attributes (flowability, strength, dissolution profile, etc) from a fine powder feed. The granulation process is a key step in the production of a wide range of products important to the UK manufacturing industries including pharmaceuticals (GSK, Astra Zeneca), food and consumer products (Nestle, Procter and Gamble, Unilever), agricultural and specialty chemicals (Syngenta). It is often the most problematic step and can cause problems in product quality, time to market, and increased cost through unnecessarily high recycle.Despite its industrial importance, approaches to the design and scaling of granulation processes are still very empirical in practice. Transfer of knowledge to new formulations, or to new equipment designs is difficult at best. The goal of this project is to develop a compartment based modeling framework for design and scaling dense phase wet granulation processes. We will develop and validate coupled discrete element (DEM)/population balance (PB) models to predict the evolution of granule property distributions for dense phase wet granulators. The specific project objectives are to:1. Develop compartment based multiscale design models for dense phase wet granulation processes;2. Validate these models using laboratory scale batch high shear wet granulators; and 3. Develop gSOLIDS modules for batch and continuous wet granulators and use these to develop and implement educational case studies.The project will develop a new collaboration between Sheffield University and Purdue University (USA) through the visiting scientist, Professor Jim Litster from Purdue. A key outcome of the project will be the development of new tools to support the UK manufacturing industries in efficient manufacture of structured particulate products.

湿造粒是使用液体粘合剂从难以处理的细粉末中形成结构良好、性能良好的颗粒的过程。造粒允许从细粉饲料中开发具有定义属性（流动性，强度，溶解轮廓等）的结构化颗粒产品。造粒过程是英国制造业生产一系列重要产品的关键步骤，包括制药（GSK, Astra Zeneca），食品和消费品（雀巢，宝洁，联合利华），农业和特种化学品（先正达）。这通常是最有问题的步骤，可能会导致产品质量问题，上市时间问题，并通过不必要的高回收增加成本。尽管它的工业重要性，方法的设计和缩放造粒过程仍然是非常经验的实践。将知识转移到新的配方或新的设备设计上是很困难的。这个项目的目标是开发一个基于隔间的建模框架，用于设计和缩放密相湿造粒过程。我们将开发和验证耦合离散元(DEM)/种群平衡（PB）模型，以预测密相湿制粒机颗粒性质分布的演变。具体的项目目标是：1。开发基于隔间的多尺度密相湿造粒工艺设计模型；使用实验室规模的间歇式高剪切湿式造粒机验证这些模型；和3。为间歇式和连续式湿式造粒机开发gSOLIDS模块，并使用这些模块开发和实施教育案例研究。该项目将通过来自普渡大学的客座科学家Jim Litster教授，在谢菲尔德大学和普渡大学（美国）之间开展新的合作。该项目的一个关键成果将是开发新工具，以支持英国制造业高效制造结构化颗粒产品。

项目成果

Kinetics of immersion nucleation driven by surface tension

表面张力驱动的浸入成核动力学

• DOI: 10.1016/j.powtec.2018.05.001
• 发表时间: 2018
• 期刊: Powder Technology
• 影响因子: 5.2
• 作者: Pitt K

High-shear granulation: An investigation into the granule consolidation and layering mechanism

• DOI: 10.1016/j.powtec.2019.07.076
• 发表时间: 2019-10-01
• 期刊: POWDER TECHNOLOGY
• 影响因子: 5.2
• 作者: de Koster, Stefan A. L.;Pitt, Kate;Smith, Rachel M.
• 通讯作者: Smith, Rachel M.