CASE CONTROL STUDY OF OSTEOSARCOMA AND FLUORIDE EXPOSURE

建议对骨肉瘤病例进行基于人群的病例对照研究。 在纽约州的居民中，他们被诊断出在1978年至 1987年，24岁或以下。这项研究的主要重点是 就是测试暴露在空气中的 非职业性环境中的氟化物与儿童的发病 骨肉瘤。此外，这项研究还将调查其他 潜在的危险因素，如生长发育、既往骨骼 创伤，以及产前暴露于化学物质和辐射。 病例将从纽约州癌症登记中心确认。一个 将从活的出生记录中选择相同数量的控制措施。这个 控制措施将与性别、年份和年龄相关的病例频率相匹配 并使用一种创新的方法在诊断时使用年龄。每个人都会是 从诊断之日到现在使用机动车辆 记录、电话簿等方式。的主要来源 暴露数据将是对受试者的电话采访和/或 他们的父母。医疗、牙科和学校健康记录也将 随机抽取50%的子样本。从这些数据中获得的数据 记录将用于验证面试信息。物流 将使用回归分析和其他统计技术来 评估危险因素对混杂变量的控制效果 比如社会人口状况。 由于饮用水加氟的普遍做法，以及 氟化物预防龋齿的作用，重要的是要 确定摄入氟化物是否可能是致病因素 骨肉瘤。该研究也满足了方案的要求 通过调查一个紧急问题来宣布小额赠款 癌症流行病学，通过计划一项复杂的流行病学调查， 并开发了一种新的频率匹配方法。

A population-based case-control study of osteosarcoma cases is proposed among residents of New York State who were diagnosed between 1978 and 1987, at 24 years of age or younger. The primary focus of this research is to test whether there is a positive association between exposure to fluoride in a non-occupational setting and the onset of childhood osteosarcoma. In addition, this study will also investigate other potential risk factors such as growth and development, previous bone trauma, and prenatal exposure to chemicals and radiation. Cases will be identified from the New York State Cancer Registry. An equal number of controls will be chosen from live birth records. The controls will be frequency matched to the cases regarding sex, year of and age at diagnosis using an innovative method. Each person will be traced from the date of diagnosis to the present using Motor Vehicle records, telephone directories and other methods. The primary source of exposure data will be telephone interviews with the subjects and/or their parents. Medical, dental and school health records also will be abstracted for a random 50% sub-sample. The data obtained from these records will be used to validate the interview information. Logistic regression analysis and other statistical techniques will be used to assess the effect of risk factors controlling for confounding variables such as sociodemographic status. Due to the common practice of fluoridating drinking water and the protective effect of fluoride against dental caries, it is important to determine whether fluoride intake could be an etiologic factor for osteosarcoma. This study also satisfies the requirements of the program announcement for small grants by investigating an emergent issue in cancer epidemiology, by planning a complex epidemiologic investigation, and by developing a new methodologic procedure for frequency matching.