CASE CONTROL STUDY OF OSTEOSARCOMA AND FLUORIDE EXPOSURE

骨肉瘤与氟化物暴露的病例对照研究

• 批准号: 3423672
• 负责人: EDWARD F FITZGERALD
• 金额: $ 5.16万
• 依托单位: NYSDOH/HEALTH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1993-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3423672
• 关键词: cancer registry /resource; cancer risk; case history; child (0-11); child physical development; early experience; embryo /fetus drug adverse effect; fluorine; human subject; interview; neoplasm /cancer epidemiology; osteosarcoma; pediatric neoplasm /cancer; socioenvironment; water supply; young adult human (21-34)

A population-based case-control study of osteosarcoma cases is proposed among residents of New York State who were diagnosed between 1978 and 1987, at 24 years of age or younger. The primary focus of this research is to test whether there is a positive association between exposure to fluoride in a non-occupational setting and the onset of childhood osteosarcoma. In addition, this study will also investigate other potential risk factors such as growth and development, previous bone trauma, and prenatal exposure to chemicals and radiation. Cases will be identified from the New York State Cancer Registry. An equal number of controls will be chosen from live birth records. The controls will be frequency matched to the cases regarding sex, year of and age at diagnosis using an innovative method. Each person will be traced from the date of diagnosis to the present using Motor Vehicle records, telephone directories and other methods. The primary source of exposure data will be telephone interviews with the subjects and/or their parents. Medical, dental and school health records also will be abstracted for a random 50% sub-sample. The data obtained from these records will be used to validate the interview information. Logistic regression analysis and other statistical techniques will be used to assess the effect of risk factors controlling for confounding variables such as sociodemographic status. Due to the common practice of fluoridating drinking water and the protective effect of fluoride against dental caries, it is important to determine whether fluoride intake could be an etiologic factor for osteosarcoma. This study also satisfies the requirements of the program announcement for small grants by investigating an emergent issue in cancer epidemiology, by planning a complex epidemiologic investigation, and by developing a new methodologic procedure for frequency matching.

建议对骨肉瘤病例进行以人群为基础的病例对照研究 在1978年至1999年确诊的纽约州居民中， 1987年，24岁或以下。 这项研究的主要焦点是 是为了测试是否有一个积极的联系， 非职业环境中的氟与儿童期的发病 骨肉瘤 此外，本研究还将探讨其他 潜在的危险因素，如生长和发育，以前的骨骼 创伤和产前暴露于化学品和辐射。 病例将从纽约州癌症登记处确定。 一个 将从活产记录中选择相同数量的对照。 的 对照将与性别、出生年份等病例频率匹配 和诊断时的年龄。 将向每位人员 从诊断之日起至现在使用机动车 记录、电话簿和其他方法。 的主要来源 暴露数据将是与受试者的电话访谈和/或 他们的父母 医疗、牙科和学校健康记录也将被 随机抽取50%的子样本。 从这些获得的数据 记录将用于验证面谈信息。 Logistic 回归分析和其他统计技术将用于 评估控制混杂变量的风险因素的影响 例如社会人口状况。 由于饮用水加氟的普遍做法和 氟对龋齿的保护作用，重要的是 确定氟摄入是否可能是一个致病因素， 骨肉瘤 本研究也满足方案要求 通过调查一个紧急问题， 癌症流行病学，通过计划一个复杂的流行病学调查， 并提出了一种新的频率匹配方法。