Sound bullets for enhanced biomedical ultrasound systems

用于增强型生物医学超声系统的声子弹

• 批准号: EP/K030159/1
• 负责人: David Hutchins
• 金额: $ 43.58万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FK030159%2F1
• 关键词: Sound; bullets; enhanced; biomedical; ultrasound

Ultrasound is used in many applications, including medical imaging, non-destructive evaluation, therapeutic ultrasound etc. In all these cases, there is usually a need for the formation of images or the creation of a focal region. Current methods for the generation of optimal acoustic fields generally rely on a linear process within the transducer. This linear transduction process influences the resultant properties in terms of spatial resolution and maximum intensity, noting that there are fundamental limits on the spatial resolution and power densities that can be achieved in such focal regions. In recent work in the area of acoustics, it has been demonstrated that a new type of acoustic signal can be generated via non-linear effects in chains of particles, which act as a kind of waveguide. These are based on the propagation of solitary waves. These have been studies at low frequencies, but this study will look at the posibility of using these new structures for use in biomedical ultrasound. Materials that support solitary waves are not used in standard ultrasonic work; little has been published on their use, despite the fact that a step change in performance may be possible. In this proposal, such waves will be generated within ultrasonic sources containing multiple solitary wave chains, at frequencies in the 500 kHz - 5 MHz range. To our knowledge, this has not been investigated before. Arrays are also possible, where each chain forms a single element. Because the chains would be primarily coupled along their length, but not laterally between each chains, issues arising from mechanical cross-coupling might be avoided. Pre-compression of each chain would alter the propagation velocity within it, so that beam-steering/focussing to be created. The propagation charaistics also change with signal amplitude, leading to the possibility of an acoustic diode. These new innovations would have applications in such areas as ultrasound-enhanced drug delivery, High Intensity Focussed Ultrasound (HIFU) for the treatment of tumours, and harmonic imaging.

超声用于许多应用中，包括医学成像、非破坏性评估、治疗性超声等。在所有这些情况下，通常需要形成图像或创建焦点区域。用于产生最佳声场的当前方法通常依赖于换能器内的线性过程。这种线性转换过程影响了空间分辨率和最大强度方面的所得性质，注意到在这种聚焦区域中可以实现的空间分辨率和功率密度存在基本限制。在声学领域的最新工作中，已经证明了一种新型的声学信号可以通过颗粒链中的非线性效应产生，颗粒链充当一种波导。这些都是基于孤立波的传播。这些都是在低频下进行的研究，但这项研究将着眼于将这些新结构用于生物医学超声的可能性。支持孤立波的材料不用于标准的超声工作;很少有关于它们的使用的出版物，尽管性能的阶跃变化是可能的。在该提议中，这种波将在包含多个孤波链的超声源内产生，频率在500 kHz - 5 MHz范围内。据我们所知，以前没有对此进行过调查。数组也是可能的，其中每个链形成单个元素。因为链将主要沿它们的长度沿着耦合，而不是在每个链之间横向耦合，所以可以避免由机械交叉耦合引起的问题。每个链的预压缩将改变其内的传播速度，从而创建波束转向/聚焦。传播特性也随着信号幅度的变化而变化，导致了声二极管的可能性。这些新的创新将在超声增强药物输送、治疗肿瘤的高强度聚焦超声（HIFU）和谐波成像等领域得到应用。

项目成果

The dynamic excitation of a granular chain: Contact mechanics finite element analysis and experimental validation.

颗粒链的动态激励：接触力学有限元分析和实验验证。

• DOI: 10.1121/1.4983466
• 发表时间: 2017
• 期刊: The Journal of the Acoustical Society of America
• 作者: Gélat P

Generation of Ultrasound Pulses in Water Using Granular Chains with a Finite Matching Layer

使用具有有限匹配层的颗粒链在水中生成超声波脉冲

• DOI: 10.1103/physrevapplied.8.054032
• 发表时间: 2017
• 期刊: Physical Review Applied
• 影响因子: 4.6
• 作者: Harput S

Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates

• DOI: 10.1109/ultsym.2016.7728393
• 发表时间: 2016-09
• 期刊: 2016 IEEE International Ultrasonics Symposium (IUS)
• 作者: S. Harput;Luzhen Nie;D. Cowell;T. Carpenter;B. Raiton;J. Mclaughlan;S. Freear

Simultaneous Acoustic Trapping and Imaging of Microbubbles at Clinically Relevant Flow Rates

在临床相关流速下同时对微泡进行声学捕获和成像

• DOI: 10.48550/arxiv.1902.01956
• 发表时间: 2019
• 作者: Harput S

Optimisation of an acoustic resonator for particle manipulation in air

• DOI: 10.1016/j.snb.2015.10.068
• 发表时间: 2016-03-01
• 期刊: SENSORS AND ACTUATORS B-CHEMICAL
• 影响因子: 8.4
• 作者: Devendran, Citsabehsan;Billson, Duncan R.;Neild, Adrian
• 通讯作者: Neild, Adrian