High resolution biomedical imaging using ultrasonic metamaterials
使用超声波超材料的高分辨率生物医学成像
基本信息
- 批准号:EP/N034163/1
- 负责人:
- 金额:$ 49.84万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2016
- 资助国家:英国
- 起止时间:2016 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Ultrasound biomedical imaging is used routinely for the diagnosis of many diseases. It has the ability show detailed structures of soft tissues, and has the advantage over other imaging methods, such as CT or MRI imaging, of being relatively cheap and portable. It is thus a good method for many diagnostic clinical settings. The current resolution of ultrasonic imaging in the body is determined by various factors, including transducer design, frequency of operation, and depth of penetration required. However, there is a fundamental limit to the imaging performance of such systems - namely the diffraction limit. This sets the minimum spot size that a focused beam can achieve by conventional means, even in a perfect propagation medium. The present proposal aims to improve this by the use of metamaterials, which will be incorporated within an ultrasonic transducer system. These exotic materials are, in fact, made up of a complicated geometry, where the internal structure contains many sub-wavelength features. These can act together to make the material behave in a way that is totally different from normal structures. The result is that they can, for example, have a negative refractive index, noting that for conventional materials the value is always positive. Thus, a plate with flat parallel sides can focus ultrasound, provided it is designed correctly.The research will identify the best designs that can be used at biomedical ultrasound frequencies, which in the present case will be 1-5 MHz. To date, acoustic metamaterials have been designed typically for much lower frequency, and for use in air. In this project, novel new designs are proposed, which will first be modelled theoretically, and then constructed using high-resolution additive manufacturing (3D printing) techniques. Once built, the new structures will be tested with biomedical ultrasound transducers, and their performance in imaging systems determined. In this way, it is hoped to produce a new approach to diagnostic ultrasound, with resolution enhancement that could be useful for cardiovascular disease, prostate and skin cancer diagnosis.
超声生物医学成像被常规用于许多疾病的诊断。它能够显示软组织的详细结构,与CT或MRI成像等其他成像方法相比,具有相对便宜和便携的优势。因此,它是一种很好的方法,适用于许多诊断临床环境。目前超声成像在体内的分辨率由各种因素决定,包括换能器设计、操作频率和所需的穿透深度。然而,这类系统的成像性能有一个基本的限制--即衍射限制。这设置了聚焦光束可以通过传统方法实现的最小光斑尺寸,即使在理想的传播介质中也是如此。目前的提议旨在通过使用超材料来改善这一点,这种材料将被并入超声波换能器系统。事实上,这些奇异的物质是由一个复杂的几何结构组成的,其内部结构包含许多亚波长特征。它们可以共同作用,使材料的行为方式与正常结构完全不同。其结果是,例如,它们可以有负的折射率,注意到对于传统材料来说,该值总是正值。因此,只要设计正确,具有平坦平行边的平板就可以聚焦超声波。研究将确定可以用于生物医学超声频率的最佳设计,在目前的情况下,该频率将为1-5 MHz。到目前为止,声学超材料通常被设计为低得多的频率,并用于空气中。在这个项目中,提出了新颖的新设计,首先将从理论上建模,然后使用高分辨率加法制造(3D打印)技术来构建。一旦建成,新的结构将用生物医学超声换能器进行测试,并确定它们在成像系统中的性能。通过这种方式,它有望产生一种新的超声诊断方法,分辨率提高,可能对心血管疾病、前列腺癌和皮肤癌的诊断有用。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Holey-structured tungsten metamaterials for broadband ultrasonic sub-wavelength imaging in water.
- DOI:10.1121/10.0005483
- 发表时间:2021-07
- 期刊:
- 影响因子:0
- 作者:Lorenzo Astolfi;D. Hutchins;P. Thomas;R. Watson;Luzhen Nie;S. Freear;A. Clare;M. Ricci;S. Laur
- 通讯作者:Lorenzo Astolfi;D. Hutchins;P. Thomas;R. Watson;Luzhen Nie;S. Freear;A. Clare;M. Ricci;S. Laur
Negative refraction in conventional and additively manufactured phononic crystals
传统和增材制造的声子晶体中的负折射
- DOI:10.1109/ultsym.2019.8926236
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Astolfi L
- 通讯作者:Astolfi L
Trapped air metamaterials for ultrasonic sub-wavelength imaging in water
用于水中超声亚波长成像的截留空气超材料
- DOI:10.48550/arxiv.2002.02212
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Laureti S
- 通讯作者:Laureti S
A Metallic Additively Manufactured Metamaterial for Enhanced Monitoring of Acoustic Cavitation-Based Therapeutic Ultrasound
用于增强声空化治疗性超声监测的金属增材制造超材料
- DOI:10.1002/adem.202100972
- 发表时间:2021
- 期刊:
- 影响因子:3.6
- 作者:Nie L
- 通讯作者:Nie L
High-resolution acoustic imaging at low frequencies using 3D-printed metamaterials
- DOI:10.1063/1.4968606
- 发表时间:2016-12-01
- 期刊:
- 影响因子:1.6
- 作者:Laureti, S.;Hutchins, D. A.;Ricci, M.
- 通讯作者:Ricci, M.
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David Hutchins其他文献
Stakeholders’ Perspectives on Medication Adherence Enhancing Interventions
利益相关者对提高药物依从性干预措施的看法
- DOI:
10.1016/j.jval.2025.01.022 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:6.000
- 作者:
Bijan J. Borah;Lisa J. Pieretti;Alan J. Balch;Rajvi J. Wani;Christopher J. Daly;Dalia Dawoud;David Hutchins;Mickaël Hiligsmann;Andrew M. Peterson;Tamas Agh - 通讯作者:
Tamas Agh
Physically constrained two-stage residual network for defect sizing using capacitive imaging technique
用于使用电容成像技术进行缺陷尺寸测量的物理受限两级残差网络
- DOI:
10.1016/j.ymssp.2025.113018 - 发表时间:
2025-08-01 - 期刊:
- 影响因子:8.900
- 作者:
Guojun Fan;Xiaokang Yin;Mingrui Zhao;Martin Mwelango;Jihao Shi;David Hutchins;Xin’an Yuan;Wei Li - 通讯作者:
Wei Li
State Diabetes Prevention and Control Program Participation in the Health Disparities Collaborative: Evaluating the First 5 Years
州糖尿病预防和控制计划参与健康差异协作:评估前 5 年
- DOI:
- 发表时间:
2006 - 期刊:
- 影响因子:5.5
- 作者:
B. Larsen;M. Martin;David Hutchins;Ana Alfaro;Laura Shea - 通讯作者:
Laura Shea
Correction to: A pilot study that provides evidence of epigenetic changes among mother–child pairs living proximal to mining in the US
- DOI:
10.1007/s10653-022-01248-2 - 发表时间:
2022-03-17 - 期刊:
- 影响因子:3.800
- 作者:
Guoshuai Cai;Xuanxuan Yu;David Hutchins;Suzanne McDermott - 通讯作者:
Suzanne McDermott
Plastic plankton prosper
塑料浮游生物繁荣
- DOI:
10.1038/nclimate1839 - 发表时间:
2013-02-26 - 期刊:
- 影响因子:27.100
- 作者:
David Hutchins - 通讯作者:
David Hutchins
David Hutchins的其他文献
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{{ truncateString('David Hutchins', 18)}}的其他基金
MetacMed: Acoustic and mechanical metamaterials for biomedical and energy harvesting applications
MetacMed:用于生物医学和能量收集应用的声学和机械超材料
- 批准号:
EP/Y034635/1 - 财政年份:2024
- 资助金额:
$ 49.84万 - 项目类别:
Research Grant
NSFGEO-NERC: Understanding the consequences of changing phytoplankton elemental use efficiencies for global ocean biogeochemistry
NSFGEO-NERC:了解改变浮游植物元素利用效率对全球海洋生物地球化学的影响
- 批准号:
2149837 - 财政年份:2022
- 资助金额:
$ 49.84万 - 项目类别:
Standard Grant
Collaborative Research: Evolutionary, biochemical and biogeochemical responses of marine cyanobacteria to warming and iron limitation interactions
合作研究:海洋蓝藻对变暖和铁限制相互作用的进化、生化和生物地球化学反应
- 批准号:
1851222 - 财政年份:2019
- 资助金额:
$ 49.84万 - 项目类别:
Standard Grant
Collaborative Research: Iron and phosphorus balanced limitation of nitrogen fixation in the oligotrophic ocean
合作研究:贫营养海洋固氮的铁磷平衡限制
- 批准号:
1657757 - 财政年份:2017
- 资助金额:
$ 49.84万 - 项目类别:
Standard Grant
Dimensions: Collaborative Research: Genetic, functional and phylogenetic diversity determines marine phytoplankton community responses to changing temperature and nutrients
维度:合作研究:遗传、功能和系统发育多样性决定海洋浮游植物群落对温度和营养物质变化的反应
- 批准号:
1638804 - 财政年份:2016
- 资助金额:
$ 49.84万 - 项目类别:
Standard Grant
2014 Ocean Global Change Biology Gordon Research Conference
2014年海洋全球变化生物学戈登研究会议
- 批准号:
1422113 - 财政年份:2014
- 资助金额:
$ 49.84万 - 项目类别:
Standard Grant
Collaborative research: Adaptation of key N2-fixing cyanobacteria to changing CO2
合作研究:关键固氮蓝细菌对二氧化碳变化的适应
- 批准号:
1260490 - 财政年份:2013
- 资助金额:
$ 49.84万 - 项目类别:
Standard Grant
Sound bullets for enhanced biomedical ultrasound systems
用于增强型生物医学超声系统的声子弹
- 批准号:
EP/K030159/1 - 财政年份:2013
- 资助金额:
$ 49.84万 - 项目类别:
Research Grant
EAGER: Gene expression patterns in high C02-adapted Trichodesmium
EAGER:高CO2适应的Trichodesmium中的基因表达模式
- 批准号:
1143760 - 财政年份:2011
- 资助金额:
$ 49.84万 - 项目类别:
Standard Grant
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