GORDON CONFERENCE ON FIBRONECTIN & RELATED MACROMOLECULE

戈登纤维连接蛋白会议

• 批准号: 3434151
• 负责人: MICHAEL D PIERSCHBACHER
• 金额: $ 0.75万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 1992-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434151
• 关键词: cell adhesion molecules; extracellular matrix proteins; fibrin; fibrinogen; fibronectins; glycoprotein structure; integrins; laminin; meeting /conference /symposium; protein structure function; thrombospondins; vitronectin; von Willebrand factor

The paradigm of an extracellular adhesion, fibronectin, interacting with a transmembrane receptor has proven applicable to a number of adhesion systems. There are several other extracellular glycoproteins with biological properties like fibronectin, laminin, thrombospondin, von Willebrand factor, fibrinogen/fibrin, vitronectin, and cytotactin/tenascin/hexabrachion. The structures of each of these proteins either are or very soon will be determined, opening up new possibilities for studies of function. In parallel has come the realization that the transmembrane receptor for fibronectin is only one member of the integrin family of functionally related, homologous, cell adhesion receptors. Fibronectin and related macromolecules are involved in many basic functions of cells, including cell adhesion, determination of cell shape and differentiation, cell migration, cytoskeletal organization, and organization of extracellular matrix. Thus, fibronectin and the molecules with which it interacts are important in embryogenesis, connective tissue organization, hemostasis, thrombosis, wound healing, development of immunity, hemopoiesis, malignant transformation, and tumor metastasis. The challenges to the field over the next several years are to comprehend and organize the large amount of new structural information and design experiments based upon it; learn the relative biological importance of the several seemingly redundant systems; and apply the new insights to the treatment of human diseases. The 1991 Gordon Research Conference will serve as a valuable forum to present and discuss new information, identify problem areas, and plan new approaches.

细胞外粘附，纤维连接蛋白，与 跨膜受体已被证明适用于许多粘附 系统. 还有几种其他的胞外糖蛋白， 生物学特性，如纤连蛋白、层粘连蛋白、血小板反应蛋白、血管内皮细胞生长因子等。 维勒布兰德因子、纤维蛋白原/纤维蛋白、玻连蛋白和 细胞增殖素/腱生蛋白/六臂蛋白。 每一个的结构 蛋白质要么是或很快将被确定，开辟新的 研究功能的可能性。 与此同时， 认识到纤连蛋白的跨膜受体只有一个， 功能相关的同源细胞的整合素家族成员 粘附受体 纤维连接蛋白及相关大分子参与 在细胞的许多基本功能中，包括细胞粘附、决定 细胞形状和分化，细胞迁移，细胞骨架 组织和细胞外基质的组织。 因此，在本发明中， 纤连蛋白及其相互作用的分子在 胚胎发生、结缔组织组织形成、止血、血栓形成， 伤口愈合，免疫发育，造血，恶性 转化和肿瘤转移。 对这个领域的挑战 在接下来的几年里，我们要理解和组织大量的 新的结构信息和基于它的设计实验;学习 几个看似多余的基因的相对生物学重要性 系统;并将新的见解应用于人类疾病的治疗。 1991年戈登研究会议将作为一个宝贵的论坛， 介绍和讨论新信息，确定问题领域，并计划新的 接近。