Sonopill: minimally invasive gastrointestinal diagnosis and therapy

Sonopill:微创胃肠道诊断和治疗

基本信息

  • 批准号:
    EP/K034537/2
  • 负责人:
  • 金额:
    $ 409.1万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2015
  • 资助国家:
    英国
  • 起止时间:
    2015 至 无数据
  • 项目状态:
    已结题

项目摘要

Capsule endoscopy for medical diagnosis in the gastrointestinal (GI) tract has emerged only in the past 10 years. Now established in "pillcams", which have benefitted more than 1 m patients worldwide, it is a clear candidate for further innovation.Most capsule endoscopy devices record and transmit video data representing the visual appearance of the inside of the gut, but work has begun on other diagnostic techniques, such as the measurement of pH, and there has been some research into the use of capsules for treatment as well.Medical ultrasound imaging is a safe, inexpensive technique which can be applied in real-time at the point of care. Ultrasound is also capable of treatment through focused ultrasound surgery and, in research, for targeted drug delivery.The core of the Sonopill programme is the exploration of ultrasound imaging and therapeutic capabilities deployed in capsule format. This will be supported by extensive pre-clinical work to demonstrate the complementary nature of ultrasound and visual imaging, along with studies of multimodal diagnosis and therapy, and of mechanisms to control the motion of the Sonopill as it travels through the GI tract. This brings research challenges and opportunities in areas including ultrasound device and systems design, microengineering and microelectronic packaging, autonomous capsule positioning, sensor suites for diagnosis and intervention, and routes to translation into clinical practice. Our carefully structured but open-ended approach maximises the possibility to meet these research challenges while delivering for the UK a sustainable international lead in multimodality capsule endoscopy, to provide greater capabilities for the clinician, more acceptable practice for the patient population, and lower costs for economic wellbeing.
用于胃肠道医学诊断的胶囊内窥镜检查是在过去 10 年才出现的。现在,它已在“药丸摄像机”中建立,已使全球超过 100 万患者受益,显然是进一步创新的候选者。大多数胶囊内窥镜设备记录和传输代表肠道内部视觉外观的视频数据,但其他诊断技术(例如 pH 测量)的工作已经开始,并且也有一些关于使用胶囊进行治疗的研究。医学超声成像是一种安全、可靠的技术。 可以在护理点实时应用的廉价技术。超声波还能够通过聚焦超声波手术进行治疗,并在研究中用于靶向药物输送。Sonopill 项目的核心是探索以胶囊形式部署的超声波成像和治疗能力。这将得到广泛的临床前工作的支持,以证明超声和视觉成像的互补性,以及多模式诊断和治疗的研究,以及控制 Sonopill 通过胃肠道运动的机制。这给超声设备和系统设计、微工程和微电子封装、自主胶囊定位、诊断和干预传感器套件以及转化为临床实践的途径等领域带来了研究挑战和机遇。我们精心构建但开放式的方法最大限度地提高了应对这些研究挑战的可能性,同时为英国提供多模态胶囊内窥镜检查方面可持续的国际领先地位,为临床医生提供更强大的能力,为患者群体提供更容易接受的实践,并降低经济福祉的成本。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Nanotechnology in multimodal theranostic capsule endoscopy
纳米技术在多模式治疗诊断胶囊内窥镜检查中的应用
  • DOI:
    10.1109/nano.2017.8117439
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Cochran S
  • 通讯作者:
    Cochran S
Acoustic radiation pressure as a versatile tool for cell compression and mechanobiology studies
声辐射压力作为细胞压缩和力学生物学研究的多功能工具
  • DOI:
    10.1109/ultsym.2017.8092765
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Bentivegna V
  • 通讯作者:
    Bentivegna V
Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids.
  • DOI:
    10.1242/jcs.211656
  • 发表时间:
    2017-11-15
  • 期刊:
  • 影响因子:
    4
  • 作者:
    Carroll TD;Langlands AJ;Osborne JM;Newton IP;Appleton PL;Näthke I
  • 通讯作者:
    Näthke I
Design and characterisation of a micro-US linear array based on randomised piezocomposite
基于随机压电复合材料的微型超声线性阵列的设计和表征
  • DOI:
    10.1109/ius52206.2021.9593812
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Boonruang A
  • 通讯作者:
    Boonruang A
Delayed activation of the DNA replication licensing system in Lgr5(+) intestinal stem cells
Lgr5( )肠道干细胞中DNA复制许可系统的延迟激活
  • DOI:
    10.1101/177477
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Carroll T
  • 通讯作者:
    Carroll T
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Sandy Cochran其他文献

Introduction of a Measurement Setup to Monitor the Pressure Applied During Handheld Ultrasound Elastography
  • DOI:
    10.1016/j.ultrasmedbio.2020.04.017
  • 发表时间:
    2020-09-01
  • 期刊:
  • 影响因子:
  • 作者:
    Katrin Skerl;Bernd Eichhorn;Romans Poltorjanoks;Sandy Cochran;Andrew Evans
  • 通讯作者:
    Andrew Evans
Design and fabrication of PMN-PT based high frequency ultrasound imaging devices integrated into medical interventional tools
基于 PMN-PT 的高频超声成像设备的设计和制造集成到医疗介入工具中
Can Mn:PIN-PMN-PT piezocrystal replace hard piezoceramic in power ultrasonic devices?
Mn:PIN-PMN-PT压电晶体能否替代功率超声器件中的硬质压电陶瓷?
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    4.2
  • 作者:
    Xuan Li;Nicola Giuseppe Fenu;N. Giles;Sandy Cochran;Margaret Lucas
  • 通讯作者:
    Margaret Lucas
Low-voltage coded excitation utilizing a miniaturized integrated ultrasound system employing piezoelectric 2-D arrays
利用采用压电二维阵列的小型化集成超声系统进行低压编码激励
Gastrointestinal diagnosis using non-white light imaging capsule endoscopy
使用非白光成像胶囊内镜进行胃肠道诊断
  • DOI:
    10.1038/s41575-019-0140-z
  • 发表时间:
    2019-04-15
  • 期刊:
  • 影响因子:
    51.000
  • 作者:
    Gerard Cummins;Benjamin F. Cox;Gastone Ciuti;Thineskrishna Anbarasan;Marc P. Y. Desmulliez;Sandy Cochran;Robert Steele;John N. Plevris;Anastasios Koulaouzidis
  • 通讯作者:
    Anastasios Koulaouzidis

Sandy Cochran的其他文献

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{{ truncateString('Sandy Cochran', 18)}}的其他基金

Ultrasound in a Needle: Minimally-invasive High Resolution Imaging for Neurosurgery
针中超声:神经外科微创高分辨率成像
  • 批准号:
    EP/K020250/1
  • 财政年份:
    2013
  • 资助金额:
    $ 409.1万
  • 项目类别:
    Research Grant
Sonopill: minimally invasive gastrointestinal diagnosis and therapy
Sonopill:微创胃肠道诊断和治疗
  • 批准号:
    EP/K034537/1
  • 财政年份:
    2013
  • 资助金额:
    $ 409.1万
  • 项目类别:
    Research Grant
Electronic Sonotweezers: Particle Manipulation with Ultrasonic Arrays
电子声镊:利用超声波阵列进行粒子操纵
  • 批准号:
    EP/G01213X/1
  • 财政年份:
    2009
  • 资助金额:
    $ 409.1万
  • 项目类别:
    Research Grant
Ultrasonic arrays for ultrahigh resolution real time biomedical imaging
用于超高分辨率实时生物医学成像的超声波阵列
  • 批准号:
    EP/D058961/2
  • 财政年份:
    2007
  • 资助金额:
    $ 409.1万
  • 项目类别:
    Research Grant
Ultrasonic arrays for ultrahigh resolution real time biomedical imaging
用于超高分辨率实时生物医学成像的超声波阵列
  • 批准号:
    EP/D058961/1
  • 财政年份:
    2006
  • 资助金额:
    $ 409.1万
  • 项目类别:
    Research Grant

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