Ultrasound in a Needle: Minimally-invasive High Resolution Imaging for Neurosurgery
针中超声:神经外科微创高分辨率成像
基本信息
- 批准号:EP/K020250/1
- 负责人:
- 金额:$ 92.48万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2013
- 资助国家:英国
- 起止时间:2013 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The research challenge we will tackle is to realise real-time visualisation of tissue in the brain with a needle capable of minimally-invasive, real-time, high resolution ultrasound imaging. This will, for the first time, enable the neurosurgeon to obtain immediate information about lesions and the location of critical structures in the brain intraoperatively, and thus to provide treatment with less morbidity and better patient outcomes. Our specific engineering challenge is to create a needle carrying an integrated, miniature ultrasound array for high-resolution (~100 um) neurological imaging and to demonstrate feasibility for future translation into clinical practice. Previous EPSRC-funded collaboration by the Universities of Birmingham and Dundee has shown that piezocomposite material with microscale features can be realised with net-shape micromoulding techniques. Single element transducers based on these materials have been evaluated already and exploratory studies with Heriot-Watt University have demonstrated the capability to bond dense interconnects onto the new materials at low temperature and pressure to connect kerfless imaging arrays to external imaging electronics.The research we now propose will extend and integrate this technical work with neurosurgery to determine basic capabilities using brain tissue in soft-embalmed cadavers and to explore potential surgical benefits and applications. As well as the three university partners, the work will benefit from support from four companies, covering all aspects of the technology as well as its translation into clinical practice.
我们要解决的研究挑战是用一根能够进行微创、实时、高分辨率超声成像的针来实现大脑组织的实时可视化。这将首次使神经外科医生能够在术中获得有关病变和大脑关键结构位置的即时信息,从而提供发病率更低、患者预后更好的治疗。我们的具体工程挑战是制造一种携带集成微型超声阵列的针头,用于高分辨率(~100 μ m)神经成像,并证明其未来转化为临床实践的可行性。此前由epsrc资助的伯明翰大学和邓迪大学的合作表明,具有微尺度特征的压电复合材料可以通过网状微成型技术实现。基于这些材料的单元件换能器已经进行了评估,赫瑞瓦特大学的探索性研究已经证明了在低温和低压下将致密互连连接到新材料上的能力,从而将无kerless成像阵列连接到外部成像电子设备。我们现在提出的研究将扩展并整合神经外科技术工作,以确定在软防腐尸体中使用脑组织的基本能力,并探索潜在的手术益处和应用。除了三所大学的合作伙伴外,这项工作还将受益于四家公司的支持,涵盖该技术的各个方面以及将其转化为临床实践。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Piezoelectric micromachined ultrasound transducer (PMUT) arrays for integrated sensing, actuation and imaging.
压电微机械超声传感器(PMUT)阵列,用于集成感测,启动和成像。
- DOI:10.3390/s150408020
- 发表时间:2015-04-03
- 期刊:
- 影响因子:0
- 作者:Qiu Y;Gigliotti JV;Wallace M;Griggio F;Demore CE;Cochran S;Trolier-McKinstry S
- 通讯作者:Trolier-McKinstry S
Electrical and Acoustic Materials Characterisation of Micro-Ultrasound Transducers
微超声换能器的电学和声学材料表征
- DOI:
- 发表时间:2015
- 期刊:
- 影响因子:0
- 作者:Lay HS
- 通讯作者:Lay HS
Ultrasound probes integrated into biopsy needles for improved diagnosis and guided intervention
超声探头集成到活检针中,以改善诊断和引导干预
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:McPhillips R
- 通讯作者:McPhillips R
Prototyping Micro-Ultrasound Instruments for Medical imaging
用于医学成像的微型超声仪器原型制作
- DOI:
- 发表时间:2015
- 期刊:
- 影响因子:0
- 作者:Ndum F
- 通讯作者:Ndum F
Novel packaging for integration of ultrasonic transducers in surgical needles
用于将超声换能器集成到手术针中的新型封装
- DOI:
- 发表时间:2015
- 期刊:
- 影响因子:0
- 作者:Desmulliez MPY
- 通讯作者:Desmulliez MPY
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sandy Cochran其他文献
Introduction of a Measurement Setup to Monitor the Pressure Applied During Handheld Ultrasound Elastography
- DOI:
10.1016/j.ultrasmedbio.2020.04.017 - 发表时间:
2020-09-01 - 期刊:
- 影响因子:
- 作者:
Katrin Skerl;Bernd Eichhorn;Romans Poltorjanoks;Sandy Cochran;Andrew Evans - 通讯作者:
Andrew Evans
Design and fabrication of PMN-PT based high frequency ultrasound imaging devices integrated into medical interventional tools
基于 PMN-PT 的高频超声成像设备的设计和制造集成到医疗介入工具中
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
R. Ssekitoleko;C. Démoré;Sandy Cochran;J. Ng;David Flynn;Marc P. Y. Desmulliez - 通讯作者:
Marc P. Y. Desmulliez
Can Mn:PIN-PMN-PT piezocrystal replace hard piezoceramic in power ultrasonic devices?
Mn:PIN-PMN-PT压电晶体能否替代功率超声器件中的硬质压电陶瓷?
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:4.2
- 作者:
Xuan Li;Nicola Giuseppe Fenu;N. Giles;Sandy Cochran;Margaret Lucas - 通讯作者:
Margaret Lucas
Low-voltage coded excitation utilizing a miniaturized integrated ultrasound system employing piezoelectric 2-D arrays
利用采用压电二维阵列的小型化集成超声系统进行低压编码激励
- DOI:
10.1109/tuffc.2010.1415 - 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
Simon Triger;J. Saillant;C. Démoré;Sandy Cochran;David R. S. Cumming - 通讯作者:
David R. S. Cumming
Gastrointestinal diagnosis using non-white light imaging capsule endoscopy
使用非白光成像胶囊内镜进行胃肠道诊断
- DOI:
10.1038/s41575-019-0140-z - 发表时间:
2019-04-15 - 期刊:
- 影响因子:51.000
- 作者:
Gerard Cummins;Benjamin F. Cox;Gastone Ciuti;Thineskrishna Anbarasan;Marc P. Y. Desmulliez;Sandy Cochran;Robert Steele;John N. Plevris;Anastasios Koulaouzidis - 通讯作者:
Anastasios Koulaouzidis
Sandy Cochran的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sandy Cochran', 18)}}的其他基金
Sonopill: minimally invasive gastrointestinal diagnosis and therapy
Sonopill:微创胃肠道诊断和治疗
- 批准号:
EP/K034537/2 - 财政年份:2015
- 资助金额:
$ 92.48万 - 项目类别:
Research Grant
Sonopill: minimally invasive gastrointestinal diagnosis and therapy
Sonopill:微创胃肠道诊断和治疗
- 批准号:
EP/K034537/1 - 财政年份:2013
- 资助金额:
$ 92.48万 - 项目类别:
Research Grant
Electronic Sonotweezers: Particle Manipulation with Ultrasonic Arrays
电子声镊:利用超声波阵列进行粒子操纵
- 批准号:
EP/G01213X/1 - 财政年份:2009
- 资助金额:
$ 92.48万 - 项目类别:
Research Grant
Ultrasonic arrays for ultrahigh resolution real time biomedical imaging
用于超高分辨率实时生物医学成像的超声波阵列
- 批准号:
EP/D058961/2 - 财政年份:2007
- 资助金额:
$ 92.48万 - 项目类别:
Research Grant
Ultrasonic arrays for ultrahigh resolution real time biomedical imaging
用于超高分辨率实时生物医学成像的超声波阵列
- 批准号:
EP/D058961/1 - 财政年份:2006
- 资助金额:
$ 92.48万 - 项目类别:
Research Grant
相似国自然基金
光学膜系针(Needle)法优化设计
- 批准号:69678021
- 批准年份:1996
- 资助金额:8.0 万元
- 项目类别:面上项目
相似海外基金
Needle-free microfluidic vaccine/drug delivery
无针微流控疫苗/药物输送
- 批准号:
23K20915 - 财政年份:2024
- 资助金额:
$ 92.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
CAREER: Intelligent Multi-Contrast Imaging Platform for Needle-Based Interventions
职业:用于针干预的智能多对比成像平台
- 批准号:
2238648 - 财政年份:2023
- 资助金额:
$ 92.48万 - 项目类别:
Continuing Grant
RII Track-4: NSF: An Integrated Multiphysics Machine Learning Modeling and Experimental Framework for Optimizing Micro-Needle Patches
RII Track-4:NSF:用于优化微针贴片的集成多物理场机器学习建模和实验框架
- 批准号:
2229555 - 财政年份:2023
- 资助金额:
$ 92.48万 - 项目类别:
Standard Grant
Moving the needle on needle debris: Planning a city-wide intervention to reduce publicly discarded drug paraphernalia
在针头碎片上移动针头:规划全市范围的干预措施,以减少公开丢弃的吸毒用具
- 批准号:
480857 - 财政年份:2023
- 资助金额:
$ 92.48万 - 项目类别:
Miscellaneous Programs
System for Annulus Fibrosus Repair (SAFR) – a percutaneously implantable preformed biomaterial for the repair of defects caused by either degenerative disc disease or needle puncture during nucleus pulposus replacement procedures SAFR
纤维环修复系统 (SAFR) — 一种可经皮植入的预制生物材料,用于修复髓核置换手术期间因椎间盘退行性疾病或针刺造成的缺陷
- 批准号:
10051703 - 财政年份:2023
- 资助金额:
$ 92.48万 - 项目类别:
Collaborative R&D
In vivo feasibility of a smart needle ablation treatment for liver cancer
智能针消融治疗肝癌的体内可行性
- 批准号:
10699190 - 财政年份:2023
- 资助金额:
$ 92.48万 - 项目类别:
Molecular mechanisms of the bacterial magnetic organelle surface proteins that functionalize the magnetosome as a biological magnetic needle
将磁小体功能化为生物磁针的细菌磁性细胞器表面蛋白的分子机制
- 批准号:
23H02123 - 财政年份:2023
- 资助金额:
$ 92.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Breast core-needle diagnostics in LMICs via millifluidics and direct-to-digital imaging: development and validation in Ghana
通过微流体和直接数字成像对中低收入国家进行乳腺空心针诊断:在加纳进行开发和验证
- 批准号:
10416550 - 财政年份:2023
- 资助金额:
$ 92.48万 - 项目类别:
5T-IV: photoacoustic needle with beacon pulse for ultrasound guided vascular access with Tool-Tip Tracking and Tissue Typing
5T-IV:带有信标脉冲的光声针,用于通过工具提示跟踪和组织分型进行超声引导血管通路
- 批准号:
10677283 - 财政年份:2023
- 资助金额:
$ 92.48万 - 项目类别:
Verification of a new direct inner ear drug delivery by ultrafine perfusion needle
超细灌注针直接内耳给药的验证
- 批准号:
23K08905 - 财政年份:2023
- 资助金额:
$ 92.48万 - 项目类别:
Grant-in-Aid for Scientific Research (C)