FOURTH INTERNATIONAL CONGRESS ON PAF & RELATED LIPIDS

此应用程序的目的是请求对以下各项的部分支持 第四届PAF及相关血脂国际会议 调解人将于1992年9月22日至26日在雪鸟举行， 犹他州。本届大会将重点关注我们的最新进展 了解分子生物学、生物化学、药理学、 这种有趣的磷脂的生理和临床作用 调解人。该节目将吸引不同的观众，包括 基础科学家和临床医生。国会以免费的方式运作 没有社会支持的常设实体。其组织结构 不同寻常的是，它关注的是一种分子，以及相关的脂类， 因此吸引了来自许多不同学科的研究人员， 但对脂类的新特性有着共同的兴趣。为 例如，它是第一个通过 与受体结合。该受体的一个cdna最近已经被 克隆的。此外，它的合成和降解路线是 从脂质生物化学家的角度来看很有趣，因为 酶具有戏剧性的特异性--这一特征在 脂类酶学。最近，我们的工作取得了重大进展 对这些酶的了解，包括分离形成这些酶的基因 可能启动这一过程的磷脂酶A2。 此外，已经表明，许多因素影响着 PAF的合成，包括膳食脂肪酸和可能的 在合成途径中两种酶的共价修饰。这个 菲尔德已经到了这样一个地步：大量的敌手 现在已经在各种动物模型中进行了测试 在某些情况下，甚至是临床试验。这些 无论是动物还是人类的研究，都将对 炎症(如关节炎、哮喘、炎症性疾病)研究人员 肠道疾病和再灌流损伤)、生殖生物学(自 一方面，PAF已被证明与植入有关 另一只手开始分娩)，以及凝血和 血栓形成。 许多演讲者以他们的研究而闻名国际。 然而，我们也注意到包括更年轻的调查人员， 来自其他国家的工人，以及妇女和少数民族。这个 国会将举行全体会议，在这些会议上，几乎所有 将邀请演讲者，尽管一些名额尚未确定 为从现在到下一年的新发展留出空间 国会。在下午，将有并发会话和 其中许多活动将由特邀演讲者发起。然而， 其他的将从提交的摘要中填写，这些摘要将被评审 由组委会主办。

The purpose of this application is to request partial support for The Fourth International Congress on PAF and Related Lipid Mediators that will occur from September 22-26, 1992 at Snowbird, Utah. This Congress will focus on the recent advances in our understanding of the molecular biology, biochemistry, pharmacology, physiology, and clinical actions of this interesting phospholipid mediator. The program will appeal to a diverse audience including basic scientists and clinicians. The Congress operates as a free standing entity without the support of a society. Its organization is unusual in that it focuses on a molecule, and related lipids, and therefore draws investigators from many different disciplines, but with a common interest in the novel features of lipid. For example, it was the first phospholipid to exert its effects via binding to a receptor. A cDNA for the receptor recently has been cloned. Additionally, its routes of synthesis and degradation are interesting from the perspective of lipid biochemists since the enzymes have dramatic specificity - a trait that is unusual in lipid enzymology. There have been recent major advances in our understanding of these enzymes including isolation of cDNA's for a phospholipase A2 that probably initiates this process. Additionally, it has been shown that many factors influence the synthesis of PAF including dietary fatty acids and probable covalent modification of both enzymes in a synthetic pathway. The field has reached the point that the large number of antagonists of the PAF receptor have now been tested in various animal models of disease and even, in some cases, clinical trials. These studies, both animal and human, will be of interest to investigators in inflammation (e.g. arthritis, asthma, inflammatory bowel disease, and reperfusion injury), reproductive biology (since PAF has been shown to be involved in implantation on the one hand and initiation of labor on the other),and coagulation and thrombosis. Many of the speakers are internationally known for their research. However, we also have taken care to include younger investigators, workers from other countries, and women and minorities. The Congress will have plenary sessions, in which virtually all of the speakers will be invited although some slots have not yet been filled to leave space for new developments between now and the Congress. In the afternoons there will be concurrent sessions and many of these will be initiated by an invited speaker. However, the others will filled from submitted abstracts that will be judged by the Organizing Committee.