FOURTH INTERNATIONAL CONGRESS ON PAF & RELATED LIPIDS

本申请的目的是请求部分支持， 第四届PAF及相关脂质国际会议 调解员将于1992年9月22日至26日在雪鸟， 犹他州。 本次大会将重点讨论我们在这方面的最新进展。 对分子生物学，生物化学，药理学， 这种有趣的磷脂的生理和临床作用 调解员 该计划将吸引不同的观众，包括 基础科学家和临床医生。 国会作为一个自由的 一个没有社会支持的实体。 其组织 是不寻常的，因为它集中在一个分子，和相关的脂质， 因此吸引了许多不同学科的研究人员， 但对脂质的新特性有共同的兴趣。 为 例如，它是第一个通过以下途径发挥作用的磷脂： 与受体结合。 该受体的cDNA最近已被 克隆的 此外，其合成和降解途径是 从脂质生物化学家的角度来看， 酶具有戏剧性的特异性-这是一个不寻常的特点， 脂类酶学 最近，我们的研究取得了重大进展， 这些酶的理解，包括cDNA的分离， 一种磷脂酶A2可能启动了这一过程。 此外，已经表明，许多因素影响 PAF的合成包括膳食脂肪酸和可能的 合成途径中两种酶的共价修饰。 的 这个领域已经达到了这样一个地步， PAF受体已经在各种动物模型中进行了测试 甚至在某些情况下，临床试验。 这些 动物和人类的研究， 炎症研究者（如关节炎、哮喘、炎性 肠道疾病和再灌注损伤），生殖生物学（因为 PAF已被证明参与植入一方面 另一方面，劳动力的启动），以及凝血， 血栓形成 许多演讲者因其研究而享誉国际。 然而，我们也注意到了年轻的研究人员， 来自其他国家的工人、妇女和少数民族。 的 国会将举行全体会议，几乎所有的议员都将在会议上发言。 发言人将被邀请，但一些插槽尚未 填补，为从现在到2010年的新发展留下空间。 国会 下午将同时举行会议， 其中许多活动将由一位受邀发言者发起。 然而，在这方面， 其他的将从提交的摘要中选出， 由组委会。

The purpose of this application is to request partial support for The Fourth International Congress on PAF and Related Lipid Mediators that will occur from September 22-26, 1992 at Snowbird, Utah. This Congress will focus on the recent advances in our understanding of the molecular biology, biochemistry, pharmacology, physiology, and clinical actions of this interesting phospholipid mediator. The program will appeal to a diverse audience including basic scientists and clinicians. The Congress operates as a free standing entity without the support of a society. Its organization is unusual in that it focuses on a molecule, and related lipids, and therefore draws investigators from many different disciplines, but with a common interest in the novel features of lipid. For example, it was the first phospholipid to exert its effects via binding to a receptor. A cDNA for the receptor recently has been cloned. Additionally, its routes of synthesis and degradation are interesting from the perspective of lipid biochemists since the enzymes have dramatic specificity - a trait that is unusual in lipid enzymology. There have been recent major advances in our understanding of these enzymes including isolation of cDNA's for a phospholipase A2 that probably initiates this process. Additionally, it has been shown that many factors influence the synthesis of PAF including dietary fatty acids and probable covalent modification of both enzymes in a synthetic pathway. The field has reached the point that the large number of antagonists of the PAF receptor have now been tested in various animal models of disease and even, in some cases, clinical trials. These studies, both animal and human, will be of interest to investigators in inflammation (e.g. arthritis, asthma, inflammatory bowel disease, and reperfusion injury), reproductive biology (since PAF has been shown to be involved in implantation on the one hand and initiation of labor on the other),and coagulation and thrombosis. Many of the speakers are internationally known for their research. However, we also have taken care to include younger investigators, workers from other countries, and women and minorities. The Congress will have plenary sessions, in which virtually all of the speakers will be invited although some slots have not yet been filled to leave space for new developments between now and the Congress. In the afternoons there will be concurrent sessions and many of these will be initiated by an invited speaker. However, the others will filled from submitted abstracts that will be judged by the Organizing Committee.