Oklahoma Medical Research Foundation Clinical Research Construction

俄克拉荷马州医学研究基金会临床研究建设

• 批准号: 7898373
• 负责人: Stephen M Prescott
• 金额: $ 703.09万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-04 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898373
• 关键词: Adult; American Indians; Arts; Autoimmune Process; Autoimmunity; Biomedical Research; Caring; Centers of Research Excellence; Certification; Childhood; Clinical; Clinical Informatics; Clinical Investigator; Clinical Research; Collection; Contracts; Cryopreservation; Dental; Disease; Enrollment; Environment; Equipment; Evaluation; Floor; Foundations; Funding; Gold; Grant; Hand; Housing; Human; Immune; Immune response; Immunology; Inflammatory; Infusion procedures; Laboratories; Leadership; Letters; Mechanics; Medical Research; Monitor; National Institute of Allergy and Infectious Disease; Native Americans; Occupations; Oklahoma; Patients; Phenotype; Recruitment Activity; Research; Research Personnel; Resources; Rheumatism; Rheumatology; Rural; Testing; U-Series Cooperative Agreements; United States; United States National Institutes of Health; Vaccination; Work; base; cold temperature; design; economic impact; experience; human disease; interstitial; operation; patient oriented research; patient population; programs; sample collection; square foot; tribal member

DESCRIPTION (provided by applicant): Building on our strengths in rheumatology, autoimmunity and immunology, as well as our unique rural and American Indian patient populations, the Oklahoma Medical Research Foundation (OMRF) requests funds to build-out approximately two floors of shell space in our eight-story Research Tower for clinical and laboratory patient-oriented research in immune-based human disease. This OMRF Research Tower is currently under construction and is located in the central United States. Funds are in hand to complete construction of the shell space for this application. This is one of the first buildings in Oklahoma to have achieved Gold certification by the US Green Building Council's Leadership in Energy and Environmental Design program. The proposed build-out will add 8,200 sf of clinical space for patient evaluation, enrollment, testing and care, as well as 16,600 sf of bench biomedical research laboratory space on the floor above for associated patient-oriented research. These new resources would support 10 current NIH- funded clinical investigators and their research teams, as well as 6 new recruits (with 3 offer letters pending). In addition, funds are requested to build-out space on the interstitial mechanical floor to serve as a Centralized Long-term Biosample Cryostorage facility (CLBC). This space will include ~913 sq. ft. of -200C space (6391 cu ft) and ~2500 cu. ft. of -75 to -800C space with shared -40C antechamber hallway space to provide for more efficient conditioned environment for the low-temperature storage rooms. The CLBC will allow careful monitoring and protection of large collections of samples of well-phenotyped patient and control collections from pediatric and adult autoimmune, immune-based and inflammatory diseases, as well as controls. The specific aims of this proposal focus on construction of state-of-the-art, multi-disciplinary, wet-bench and clinical research space with specialized ophthalmic and dental space, infusion center, clinical informatics and support space to house clinical research for large, multi- investigator NIH-funded research in autoimmunity, such as the Oklahoma Autoimmunity Center of Excellence, Oklahoma Rheumatic Disease Research Cores Center, and Native American Research Center of Excellence to Understand Rheumatic Disease in Oklahoma Tribal Members, as well as to support understanding human immune responses to various types of vaccination through NIAID funded contracts and U19 cooperative agreements. Of course, additional NIH- and Foundation-supported clinical research will also be supported by this construction. Built-in equipment required for appropriate use of this space is also requested. Additional aims focus on construction and support of large, centralized freezers and cryopreservation facilities which will support the above investigators, as well as investigators throughout OMRF. Finally, an important aim of this proposed work is to facilitate construction and operations of the new research space according to environmentally responsible and energy efficient principles that have been incorporated into the progressive design and implementation of an outstanding LEED certified facility. This work is led by a diverse, experienced, research intensive construction team. A detailed independent economic impact analysis concluded that OMRF has a $47 million annual impact on Oklahoma's economy and creates an estimated 1,061 jobs. The study also concludes that every job created by an external grant creates one additional job in this state. The proposed build-out is conservatively estimated to contribute wholly or in part to the creation of 156 jobs in Oklahoma, as well as an infusion of money for materials and equipment into at least 18 states.

描述（由申请人提供）：建立在我们的优势，在风湿病学，自身免疫和免疫学，以及我们独特的农村和美国印第安人的患者群体，俄克拉荷马州医学研究基金会（OMRF）要求资金，以建立了大约两层楼的外壳空间在我们的八层楼高的研究塔的临床和实验室病人为导向的研究免疫为基础的人类疾病。这座OMRF研究塔目前正在建设中，位于美国中部。资金已到位，以完成该应用程序的外壳空间的建设。这是俄克拉荷马州首批获得美国绿色建筑理事会能源和环境设计领导力项目金牌认证的建筑之一。拟议的扩建将增加8，200平方英尺的临床空间，用于患者评估，招募，测试和护理，以及16，600平方英尺的生物医学研究实验室空间，用于相关的面向患者的研究。这些新的资源将支持10名目前由NIH资助的临床研究人员及其研究团队，以及6名新招募的人员（3封聘书待定）。此外，还要求提供资金，在间隙机械层上建造空间，作为集中式长期生物样品冷冻储存设施。该空间将包括~913平方米。英尺-200C空间（6391立方英尺）和~2500立方英尺。英尺-75至-800 ℃的空间与共享的-40 ℃前室走廊空间，为低温储藏室提供更有效的空调环境。CLBC将允许仔细监测和保护来自儿科和成人自身免疫性、免疫性和炎性疾病以及对照的大量表型良好的患者和对照样本。本提案的具体目标是建设最先进的多学科湿台和临床研究空间，包括专门的眼科和牙科空间、输液中心、临床信息学和支持空间，以容纳NIH资助的大型多研究者自身免疫研究的临床研究，如俄克拉荷马州自身免疫卓越中心、俄克拉荷马州风湿病研究核心中心、和美洲原住民卓越研究中心，以了解俄克拉荷马州部落成员的风湿病，以及通过NIAID资助的合同和U19合作协议支持了解人类对各种疫苗接种的免疫反应。当然，其他NIH和基金会支持的临床研究也将得到这一建设的支持。还要求提供适当使用这一空间所需的内置设备。其他目标侧重于建设和支持大型集中式冰柜和冷冻保存设施，以支持上述研究人员以及整个OMRF的研究人员。最后，这项拟议工作的一个重要目标是促进新的研究空间的建设和运营，根据对环境负责和节能的原则，这些原则已被纳入一个优秀的LEED认证设施的渐进设计和实施。这项工作是由一个多元化，经验丰富，研究密集的施工团队领导。一项详细的独立经济影响分析得出结论，OMRF每年对俄克拉荷马州的经济产生4700万美元的影响，并创造了估计1,061个就业机会。该研究还得出结论，外部赠款创造的每一个就业机会都会在该州创造一个额外的就业机会。据保守估计，拟议中的扩建将全部或部分地为俄克拉荷马州创造156个就业机会，并为至少18个州注入材料和设备资金。