Oklahoma Medical Research Foundation Clinical Research Construction

俄克拉荷马州医学研究基金会临床研究建设

• 批准号: 7898373
• 负责人: Stephen M Prescott
• 金额: $ 703.09万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-04 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898373
• 关键词: Adult; American Indians; Arts; Autoimmune Process; Autoimmunity; Biomedical Research; Caring; Centers of Research Excellence; Certification; Childhood; Clinical; Clinical Informatics; Clinical Investigator; Clinical Research; Collection; Contracts; Cryopreservation; Dental; Disease; Enrollment; Environment; Equipment; Evaluation; Floor; Foundations; Funding; Gold; Grant; Hand; Housing; Human; Immune; Immune response; Immunology; Inflammatory; Infusion procedures; Laboratories; Leadership; Letters; Mechanics; Medical Research; Monitor; National Institute of Allergy and Infectious Disease; Native Americans; Occupations; Oklahoma; Patients; Phenotype; Recruitment Activity; Research; Research Personnel; Resources; Rheumatism; Rheumatology; Rural; Testing; U-Series Cooperative Agreements; United States; United States National Institutes of Health; Vaccination; Work; base; cold temperature; design; economic impact; experience; human disease; interstitial; operation; patient oriented research; patient population; programs; sample collection; square foot; tribal member

DESCRIPTION (provided by applicant): Building on our strengths in rheumatology, autoimmunity and immunology, as well as our unique rural and American Indian patient populations, the Oklahoma Medical Research Foundation (OMRF) requests funds to build-out approximately two floors of shell space in our eight-story Research Tower for clinical and laboratory patient-oriented research in immune-based human disease. This OMRF Research Tower is currently under construction and is located in the central United States. Funds are in hand to complete construction of the shell space for this application. This is one of the first buildings in Oklahoma to have achieved Gold certification by the US Green Building Council's Leadership in Energy and Environmental Design program. The proposed build-out will add 8,200 sf of clinical space for patient evaluation, enrollment, testing and care, as well as 16,600 sf of bench biomedical research laboratory space on the floor above for associated patient-oriented research. These new resources would support 10 current NIH- funded clinical investigators and their research teams, as well as 6 new recruits (with 3 offer letters pending). In addition, funds are requested to build-out space on the interstitial mechanical floor to serve as a Centralized Long-term Biosample Cryostorage facility (CLBC). This space will include ~913 sq. ft. of -200C space (6391 cu ft) and ~2500 cu. ft. of -75 to -800C space with shared -40C antechamber hallway space to provide for more efficient conditioned environment for the low-temperature storage rooms. The CLBC will allow careful monitoring and protection of large collections of samples of well-phenotyped patient and control collections from pediatric and adult autoimmune, immune-based and inflammatory diseases, as well as controls. The specific aims of this proposal focus on construction of state-of-the-art, multi-disciplinary, wet-bench and clinical research space with specialized ophthalmic and dental space, infusion center, clinical informatics and support space to house clinical research for large, multi- investigator NIH-funded research in autoimmunity, such as the Oklahoma Autoimmunity Center of Excellence, Oklahoma Rheumatic Disease Research Cores Center, and Native American Research Center of Excellence to Understand Rheumatic Disease in Oklahoma Tribal Members, as well as to support understanding human immune responses to various types of vaccination through NIAID funded contracts and U19 cooperative agreements. Of course, additional NIH- and Foundation-supported clinical research will also be supported by this construction. Built-in equipment required for appropriate use of this space is also requested. Additional aims focus on construction and support of large, centralized freezers and cryopreservation facilities which will support the above investigators, as well as investigators throughout OMRF. Finally, an important aim of this proposed work is to facilitate construction and operations of the new research space according to environmentally responsible and energy efficient principles that have been incorporated into the progressive design and implementation of an outstanding LEED certified facility. This work is led by a diverse, experienced, research intensive construction team. A detailed independent economic impact analysis concluded that OMRF has a $47 million annual impact on Oklahoma's economy and creates an estimated 1,061 jobs. The study also concludes that every job created by an external grant creates one additional job in this state. The proposed build-out is conservatively estimated to contribute wholly or in part to the creation of 156 jobs in Oklahoma, as well as an infusion of money for materials and equipment into at least 18 states.

描述（由申请人提供）：基于我们在风湿病，自身免疫性和免疫学方面的优势，以及我们独特的农村和美洲印第安人患者人群，俄克拉荷马州医学研究基金会（OMRF）要求资金在我们的临床和实验室患者八层型研究塔中大约建立了大约两层壳的壳牌空间。该OMRF研究塔目前正在建设中，位于美国中部。资金掌握在此应用程序中完成外壳空间的构造。这是俄克拉荷马州最早获得美国绿色建筑委员会在能源和环境设计计划领导的金牌认证的建筑之一。拟议的建筑物将增加8,200平方英尺的临床空间，用于患者评估，入学，测试和护理，以及上面地板上16,600平方英尺的Bench生物医学研究实验室空间，以进行相关的患者研究。这些新资源将支持10名现有NIH资助的临床研究人员及其研究团队，以及6名新的新兵（有3封供应信）。此外，还要求资金在间质机械地板上建立空间，以充当集中的长期生物样品低温固化设施（CLBC）。该空间将包括-200C空间（6391立方英尺）和〜2500 Cu的〜913平方英尺。英尺为-75至-800C的空间，具有共享-40C的横室走廊空间，为低温储藏室提供更有效的条件环境。 CLBC将仔细监测和保护大量良好的患者样品，并从儿科和成人自身免疫，免疫和炎症性疾病以及对照组中进行控制。 The specific aims of this proposal focus on construction of state-of-the-art, multi-disciplinary, wet-bench and clinical research space with specialized ophthalmic and dental space, infusion center, clinical informatics and support space to house clinical research for large, multi- investigator NIH-funded research in autoimmunity, such as the Oklahoma Autoimmunity Center of Excellence, Oklahoma Rheumatic Disease Research Cores Center, and美国原住民研究中心了解俄克拉荷马州部落成员的风湿病，并通过NIAID资助的合同和U19合作协议来支持了解人类免疫反应。当然，该建筑也将支持其他NIH和基础支持的临床研究。还请求适当使用此空间所需的内置设备。其他目的集中在建设和支持大型的集中式冰柜和冷冻保存设施上，这些设施将支持上述研究人员以及整个OMRF的研究人员。最后，这项拟议的工作的一个重要目的是根据对环境负责和节能的原则促进新研究领域的建设和运营，这些原则已纳入了逐步设计和实施，并实施了杰出的LEED认证设施。这项工作由多样化，经验丰富的研究密集建筑团队领导。一项详细的独立经济影响分析得出结论，OMRF对俄克拉荷马州的经济有4700万美元的影响，并创造了约1,061个就业机会。该研究还得出结论，外部赠款创造的每项工作都在该州创造了一项额外的工作。拟议的建筑保守地估计将全力以赴或部分贡献俄克拉荷马州的156个工作岗位，以及向至少18个州注入材料和设备的资金。