Oklahoma Medical Research Foundation Clinical Research Construction

俄克拉荷马州医学研究基金会临床研究建设

• 批准号: 7898373
• 负责人: Stephen M Prescott
• 金额: $ 703.09万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-04 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898373
• 关键词: Adult; American Indians; Arts; Autoimmune Process; Autoimmunity; Biomedical Research; Caring; Centers of Research Excellence; Certification; Childhood; Clinical; Clinical Informatics; Clinical Investigator; Clinical Research; Collection; Contracts; Cryopreservation; Dental; Disease; Enrollment; Environment; Equipment; Evaluation; Floor; Foundations; Funding; Gold; Grant; Hand; Housing; Human; Immune; Immune response; Immunology; Inflammatory; Infusion procedures; Laboratories; Leadership; Letters; Mechanics; Medical Research; Monitor; National Institute of Allergy and Infectious Disease; Native Americans; Occupations; Oklahoma; Patients; Phenotype; Recruitment Activity; Research; Research Personnel; Resources; Rheumatism; Rheumatology; Rural; Testing; U-Series Cooperative Agreements; United States; United States National Institutes of Health; Vaccination; Work; base; cold temperature; design; economic impact; experience; human disease; interstitial; operation; patient oriented research; patient population; programs; sample collection; square foot; tribal member

DESCRIPTION (provided by applicant): Building on our strengths in rheumatology, autoimmunity and immunology, as well as our unique rural and American Indian patient populations, the Oklahoma Medical Research Foundation (OMRF) requests funds to build-out approximately two floors of shell space in our eight-story Research Tower for clinical and laboratory patient-oriented research in immune-based human disease. This OMRF Research Tower is currently under construction and is located in the central United States. Funds are in hand to complete construction of the shell space for this application. This is one of the first buildings in Oklahoma to have achieved Gold certification by the US Green Building Council's Leadership in Energy and Environmental Design program. The proposed build-out will add 8,200 sf of clinical space for patient evaluation, enrollment, testing and care, as well as 16,600 sf of bench biomedical research laboratory space on the floor above for associated patient-oriented research. These new resources would support 10 current NIH- funded clinical investigators and their research teams, as well as 6 new recruits (with 3 offer letters pending). In addition, funds are requested to build-out space on the interstitial mechanical floor to serve as a Centralized Long-term Biosample Cryostorage facility (CLBC). This space will include ~913 sq. ft. of -200C space (6391 cu ft) and ~2500 cu. ft. of -75 to -800C space with shared -40C antechamber hallway space to provide for more efficient conditioned environment for the low-temperature storage rooms. The CLBC will allow careful monitoring and protection of large collections of samples of well-phenotyped patient and control collections from pediatric and adult autoimmune, immune-based and inflammatory diseases, as well as controls. The specific aims of this proposal focus on construction of state-of-the-art, multi-disciplinary, wet-bench and clinical research space with specialized ophthalmic and dental space, infusion center, clinical informatics and support space to house clinical research for large, multi- investigator NIH-funded research in autoimmunity, such as the Oklahoma Autoimmunity Center of Excellence, Oklahoma Rheumatic Disease Research Cores Center, and Native American Research Center of Excellence to Understand Rheumatic Disease in Oklahoma Tribal Members, as well as to support understanding human immune responses to various types of vaccination through NIAID funded contracts and U19 cooperative agreements. Of course, additional NIH- and Foundation-supported clinical research will also be supported by this construction. Built-in equipment required for appropriate use of this space is also requested. Additional aims focus on construction and support of large, centralized freezers and cryopreservation facilities which will support the above investigators, as well as investigators throughout OMRF. Finally, an important aim of this proposed work is to facilitate construction and operations of the new research space according to environmentally responsible and energy efficient principles that have been incorporated into the progressive design and implementation of an outstanding LEED certified facility. This work is led by a diverse, experienced, research intensive construction team. A detailed independent economic impact analysis concluded that OMRF has a $47 million annual impact on Oklahoma's economy and creates an estimated 1,061 jobs. The study also concludes that every job created by an external grant creates one additional job in this state. The proposed build-out is conservatively estimated to contribute wholly or in part to the creation of 156 jobs in Oklahoma, as well as an infusion of money for materials and equipment into at least 18 states.

描述(由申请人提供)：凭借我们在风湿学、自身免疫学和免疫学方面的优势，以及我们独特的农村和美国印第安人患者群体，俄克拉荷马医学研究基金会(OMRF)要求资金在我们八层的研究大楼中建造约两层的外壳空间，用于临床和实验室以患者为导向的免疫基础人类疾病研究。这座OMRF研究塔目前正在建设中，位于美国中部。目前已有资金为这一申请完成外壳空间的建造。这是俄克拉荷马州首批获得美国绿色建筑委员会能源与环境设计领导力项目金牌认证的建筑之一。拟议的扩建工程将增加8,200平方英尺的临床空间用于患者评估、登记、测试和护理，以及上方楼层16,600平方英尺的长凳生物医学研究实验室空间用于相关的以患者为导向的研究。这些新资源将支持10名目前由美国国立卫生研究院资助的临床研究人员及其研究团队，以及6名新招聘人员(尚有3份聘书待定)。此外，还需要资金在组织间机械地板上扩建空间，作为一个集中的长期生物样品冷冻储存设施。这个空间将包括约913平方英尺。英国《金融时报》-200摄氏度(6391立方英尺)和~2500立方英尺。英国《金融时报》-75至-800摄氏度的空间，共享-40摄氏度的前厅走廊空间，为低温储藏室提供更高效的空调环境。CLBC将允许仔细监测和保护大量表型良好的患者样本和来自儿童和成人自身免疫性、免疫性和炎症性疾病的对照样本，以及对照样本。这项建议的具体目标集中在建设最先进的、多学科的、湿润的工作台和临床研究空间，包括专门的眼科和牙科空间、输液中心、临床信息学和支持空间，以容纳由NIH资助的大型、多研究者的自身免疫研究的临床研究，如俄克拉荷马州自身免疫卓越中心、俄克拉荷马州风湿病研究核心中心和美国原住民研究中心，以了解俄克拉荷马州部落成员的风湿性疾病，并通过NIAID资助的合同和U19合作协议支持了解人类免疫对各种疫苗的反应。当然，NIH和基金会支持的其他临床研究也将得到这一建设的支持。还要求提供适当使用该空间所需的内置设备。其他目标侧重于建造和支持大型中央冰柜和冷冻保存设施，以支持上述调查人员以及整个OMRF的调查人员。最后，这项拟议工作的一个重要目标是根据对环境负责和节能的原则促进新研究空间的建造和运营，这些原则已被纳入逐步设计和实施尚未通过LEED认证的设施。这项工作由一支多元化、经验丰富、研究密集的施工团队领导。一份详细的独立经济影响分析得出结论，OMRF每年对俄克拉荷马州经济的影响为4700万美元，并估计创造了1061个就业机会。这项研究还得出结论，由外部拨款创造的每一个就业机会都会在这个州创造一个额外的就业机会。保守估计，拟议中的扩建将全部或部分为俄克拉荷马州创造156个就业机会，并为至少18个州注入材料和设备资金。