NEW DIMENSIONS OF LEAD NEUROTOXICITY

尽管几十年的研究和努力将铅降至最低 由于受到食物、水、空气和工作场所的影响，铅仍然是一种 这是这个国家和全世界的主要健康问题。联邦制 监管和咨询机构一直在不断降低 根据观察到的不利影响，铅的哪些不良影响值得关注 对人类的影响。尽管高度精炼的方法已经证明 铅对人群的不良影响和铅的多种影响 细胞和分子水平是有记录的，相对较少的是 已知的关于潜在的不利的关键生物学过程 铅对人类和实验动物的影响。 这次会议的第一个目标是为 从分子到临床层面的数据垂直整合。 这种整合将有助于关注正在进行的和未来的 基于机械论的研究努力在所有层面上 铅中毒的临床和亚临床表现的神经生物学。 通过这样做，会议将实现其第二个目标，即 识别、阐明和定义新兴的和有希望的领域 基础研究和应用研究可能有助于确定 铅神经毒性的机制基础。 这次会议是一系列成功的国际会议中的第九次 集中讨论神经毒性的选定方面的会议。四十四岁 国际公认的铅各个方面的权威机构 毒性已被邀请参加会议，给出论文定义 铅中毒的最新进展和未来发展，并提交 用于出版会议记录的手稿。到目前为止，28个 我们联系的演讲者都热情地同意了 参与进来。这些演讲者被选中是因为他们的专业知识， 对该领域的贡献，以及新的和继续的潜力 对了解铅毒性的贡献。此外，新的 将为调查人员和新兴调查领域提供 论坛通过最先进的数据演示。学生奖将是 授予研究生或住院医生提交的最佳论文奖 鼓励和认可学生在这一重要领域的努力。特价 会议的重点是提供充分的讨论。 每一次会议结束时的时间，以及小组讨论 与未来研究途径有关的重要问题。收集到的 会议论文将作为 国际期刊，神经毒理学。

Despite the decades of research and efforts to minimize lead exposure from food, water, air, and the workplace, lead continues to be a major health problem in this country and throughout the world. Federal regulatory and advisory agencies have continually lowered the levels at which adverse effects of lead are of concern based on observed adverse effects in humans. Although highly refined approaches have demonstrated adverse effects of lead in human populations and many effects of lead at the cellular and molecular level are documented, relatively little is known regarding the critical biological processes underlying the adverse effects of lead in humans and experimental animals. The first objective of this conference is to provide a forum for vertical integration of data from the molecular to the clinical level. This integration will assist in focusing ongoing and future mechanistic-based research efforts at all levels on the underlying neurobiology of clinical and subclinical manifestations of lead toxicity. In doing so, the conference will achieve its second objective, which is to identify, illuminate, and define the emerging and promising areas of basic and applied research which are likely to contribute to identifying the mechanistic b bases of the neurotoxicity of lead. This conference is the Ninth in a successful series of international conferences focusing on selected aspects of neurotoxicity. Forty-four internationally recognized authorities in various aspects of lead toxicity have been invited to attend the conference, give papers defining the state-of-the-art and future developments in lead toxicity, and submit a manuscript for the publication of the proceedings. To date, 28 of the speakers that we have contacted have all enthusiastically agreed to participate. These speakers were chosen for their expertise, knowledge, contributions to the field, and potential for new and continued contribution to understanding lead toxicity. In addition, new investigators and emerging areas of investigation will be provided a forum via state-of-the-art data presentations. A student award will be given for the best paper presented by a graduate student or resident to encourage and recognize student effort in this important area. Special emphasis at the conference has been devoted to providing ample discussion time at the end of each session, as well as for a panel discussion of important issues related to future research avenues. The collected papers of the conference will be published as a special issue of the international journal, NeuroToxicology.