Infant and Child Neurotoxicity Studies:

婴儿和儿童神经毒性研究：

• 批准号: 6757081
• 负责人: Joan Marie Cranmer
• 金额: $ 4.9万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6757081
• 关键词: Hawaiian; child (0-11); disease /disorder etiology; environmental exposure; halobiphenyl /halotriphenyl compound; hazardous substances; infant human (0-1 year); longitudinal human study; meeting /conference /symposium; mercury poisoning; methylmercury; neurotoxicology; pediatrics; travel

DESCRIPTION (provided by applicant) The 21st International Neurotoxicology Conference (NTX XXI) will be held Feb. 10-14, 2004 at the Ala Moana hotel in Honolulu, Hawaii. NTX XXI will address the theme Infant and Child Neurotoxicity Studies: Subtle and Long-Term Effects. Studies will focus on methylmercury (MeHg), PCBs, heptachlor, other persistent pollutants and mixtures. The highlight of this conference is that all the major longitudinal children's studies addressing these important pollutants will be presented together for the first time! This will allow a unique opportunity to make significant advances in our understanding of the subtle and latent effects that these chemicals -alone or in combination-may be posing to our children. Justification for Hawaii Venue: Results of two major research efforts involving Hawaiians and others from the Pacific Rim will be presented for the first time at this conference. These two major themes require the meeting to be held on Oahu. The two areas are: (1) The Hawaii Heptachlor Study (20-yr study results) and (2) Persistent Pesticides and the Honolulu-Hawaii-Asia Aging Cohort. The Hawaii Heptachlor Research and Education Foundation promised Hawaiian citizens that the results of the Heptachlor Children's Study first would be reported to the Hawaiian community. The last day of the conference will be a "Report Back to the Community" in a Public Session devoted to the Hawaii Heptachlor Study 20 years after the initial pollution. Specific Aims: (1) To provide an internationally recognized, interdisciplinary scientific forum for presentation of the major longitudinal children's studies investigating the low-level, long-term effects of MeHg, PCBs, lead, heptachlor, other pesticides and mixtures. (2) To conduct an Open Public Forum/Town Meeting for clinical and basic scientists, clinicians and the citizens of Hawaii who were involved in the 20-year Heptachlor studies. To facilitate communication between the researchers, and the parents & children from Hawaii who were exposed to Heptachlor to discuss the implications of study results. (3) To convene scientists from different sectors to exchange data and theories regarding the etiology, mechanisms, diagnosis, treatment and prevention of environmentally-induced diseases or disorders of the nervous system in the fetus, infant, child, adolescent, and latent effects in the adult. To provide an established venue and ample time for informal scientific exchange to establish and promote collaborations and networking worldwide. (4) To encourage, mentor and recognize student researchers and young neurotoxicologists by offering pre-doctoral and post-doctoral awards (cash and plaques, travel scholarships, mentoring and networking opportunities. (5) To organize the keynote presentations, tutorials, invited and free presentations, discussions, demonstrations and interactions to document, major new research advances, facilitate identification of specific research gaps and potential experimental designs to answer questions. (6) To rapidly peer review and disseminate findings to the scientific community. The overall goal will be accomplished by organizing and conducting a five-day widely-advertised and well-organized conference according to the format of previous conferences in this well-established Neurotoxicology Conference series which has proven to be very successful. All presenters are invited to submit original research papers of new data presented and/or summaries of recent findings related to the specific topics in the Program. Papers will be peer-reviewed and rapidly published (less than one year) in Neurotoxicology, an international scientific journal that is widely disseminated, indexed, abstracted and available online.

描述（由申请人提供） 第21届国际神经毒理学会议（NTX XXI）将于2004年2月10日至14日在夏威夷檀香山的Ala Moana酒店举行。 NTX XXI将讨论主题婴儿和儿童神经毒性研究：微妙和长期影响。 研究将侧重于甲基汞、多氯联苯、七氯、其他持久性污染物和混合物。 本次会议的亮点是，所有主要的纵向儿童研究解决这些重要的污染物将首次提出在一起！ 这将为我们提供一个独特的机会，使我们对这些化学物质（单独或组合）可能对我们的孩子造成的微妙和潜在影响的理解取得重大进展。 选择夏威夷的理由：涉及夏威夷人和太平洋沿岸其他人的两项主要研究成果将首次在这次会议上发表。 这两大主题要求会议在奥斯陆举行。 这两个领域是：（1）夏威夷七氯研究（20年研究结果）和（2）持久性农药和檀香山-夏威夷-亚洲老龄化队列。 夏威夷七氯研究和教育基金会向夏威夷公民承诺，将首先向夏威夷社区报告七氯儿童研究的结果。 会议的最后一天将是一个“报告回到社区”在一个公开会议上专门讨论夏威夷七氯研究20年后，最初的污染。 具体目标：（1）提供一个国际公认的跨学科科学论坛，介绍关于甲基汞、多氯联苯、铅、七氯、其他农药和混合物的低水平长期影响的主要纵向儿童研究。(2)为参与20年七氯研究的临床和基础科学家、临床医生和夏威夷公民举办公开公共论坛/城镇会议。 促进研究人员与来自夏威夷的接触七氯的父母和儿童之间的沟通，讨论研究结果的影响。(3)召集来自不同部门的科学家交流关于胎儿、婴儿、儿童、青少年环境引起的神经系统疾病或障碍的病因、机制、诊断、治疗和预防以及对成人的潜在影响的数据和理论。 为非正式的科学交流提供一个固定的场所和充足的时间，以建立和促进全世界的合作和网络。(4)通过提供博士前和博士后奖励（现金和奖牌，旅行奖学金，指导和网络机会）来鼓励，指导和认可学生研究人员和年轻的神经毒理学家。(5)组织主题演讲，教程，邀请和免费演讲，讨论，演示和互动，以记录主要的新研究进展，促进识别特定的研究差距和潜在的实验设计，以回答问题。(6)迅速进行同行审查并向科学界传播研究结果。 总体目标将通过组织和进行为期五天的广泛宣传和组织良好的会议来实现，会议将按照这个成熟的神经毒理学会议系列中以前会议的形式进行，该会议已被证明非常成功。 所有演讲者都被邀请提交新数据的原始研究论文和/或与该计划中的特定主题相关的最新发现的摘要。 论文将经过同行评审并迅速发表（不到一年）在神经毒理学上，这是一份国际科学期刊，广泛传播，索引，摘要和在线提供。