WORKSHOP: CHANGING PATTERNS IN SYSTEMIC FLUORIDE INTAKE

很明显，中国儿童全身氟化物摄入量的模式 在过去的几十年里，美国发生了变化。这些变化是 部分原因是人口患龋率的下降，而不是 饮用含氟水。这些变化的最确凿证据 观察到的极轻度和轻度氟中毒患病率的增加 在未加氟的人群中。鉴于这些观察和其他 证据，已经多次指出，目前的建议 关于氟化物补充剂量，氟化物浓度应为 在饮用水中使用，集中需求是 1989年由NIDR主办的氟化物研讨会。这一需求变得更加迫切 由于公众对过早发布的数据感到担忧， NIEHS氟化物毒理学研究。 本申请书中提议的讲习班的具体目标是： (1)对数据和影响进行全面审查 与全身氟摄取来源和模式的变化有关 在美国； (2)确定目前批准的氟化物补充剂量 应修改时间表，如果是，则建议新的时间表； (3)确定目前批准的有关建议是否 公共供水中使用的最佳氟化物水平应为 进行修订，如果这样做，则制定新的建议； (4)制定关于最高浓度的建议 各种外用氟化物制剂中所含的氟化物。 研讨会将于1991年4月22日至24日在北卡罗来纳州的教堂山举行。

It is clear that patterns of systemic fluoride intake by children in the United States have changed in the last several decades. These changes are responsible in part for the decline in caries prevalence in populations not drinking fluoridated water. The most conclusive evidence of such changes is the observed increase in the prevalence of very mild and mild fluorosis in the non-fluoridated population. In view of these observations and other evidence, it has been stated repeatedly that current recommendations concerning the fluoride supplement dose, concentrations of fluoride to be used in drinking water, and concentrations of need was a major theme of the 1989 fluoride symposium sponsored by NIDR. The need has become more urgent as a result of public concern related to the prematurely released data from the NIEHS fluoride toxicology study. The specific aims for the workshop proposed in this application are: (1) To provide a comprehensive review of data and implications related to changing sources and patterns of systemic fluoride intake in the United States; (2) To determine if the currently approved fluoride supplement dose schedule should be revised and, if so, to recommend a new schedule; (3) To determine if the currently approved recommendations concerning optimal levels of fluoride to be used in public water supplies should be revised and, if so, to develop new recommendations; (4) To develop recommendations concerning the maximum concentrations of fluoride to be contained in various topical fluoride agents. The workshop is to be held in Chapel Hill, N.C., April 22-24, 1991.