WORKSHOP: CHANGING PATTERNS IN SYSTEMIC FLUORIDE INTAKE

很明显，儿童的全身氟摄入模式， 美国在过去的几十年里发生了变化。 这些变化是 部分原因是龋齿患病率的下降， 饮用含氟水。 这种变化的最确凿证据 是观察到的极轻度和轻度氟中毒患病率的增加 在非氟化人群中。 鉴于这些意见和其他 有证据表明，目前的建议 关于氟化物补充剂量， 在饮用水中使用，和需要的浓度是一个主要的主题， 1989年由NIDR主办的氟化物研讨会。 需求变得更加迫切 由于公众对过早发布的数据表示担忧， NIEHS氟化物毒理学研究。 本申请中提议的讲习班的具体目标是： (1)全面审查数据和影响 与不断变化的系统性 摄氟量 在美国; (2)为了确定目前批准的氟化物补充剂 剂量 时间表应予以修订，如果是这样，建议一个 新的时间表; (3)以确定目前批准的建议是否 关于 公众使用的最佳氟化物水平 供水应 修订，如果是，则制定新的 建议; (4)拟订关于最高 浓度 氟化物的含量， 局部氟化物制剂。 研讨会将在北卡罗来纳州的查佩尔山举行，1991年4月22日至24日。

It is clear that patterns of systemic fluoride intake by children in the United States have changed in the last several decades. These changes are responsible in part for the decline in caries prevalence in populations not drinking fluoridated water. The most conclusive evidence of such changes is the observed increase in the prevalence of very mild and mild fluorosis in the non-fluoridated population. In view of these observations and other evidence, it has been stated repeatedly that current recommendations concerning the fluoride supplement dose, concentrations of fluoride to be used in drinking water, and concentrations of need was a major theme of the 1989 fluoride symposium sponsored by NIDR. The need has become more urgent as a result of public concern related to the prematurely released data from the NIEHS fluoride toxicology study. The specific aims for the workshop proposed in this application are: (1) To provide a comprehensive review of data and implications related to changing sources and patterns of systemic fluoride intake in the United States; (2) To determine if the currently approved fluoride supplement dose schedule should be revised and, if so, to recommend a new schedule; (3) To determine if the currently approved recommendations concerning optimal levels of fluoride to be used in public water supplies should be revised and, if so, to develop new recommendations; (4) To develop recommendations concerning the maximum concentrations of fluoride to be contained in various topical fluoride agents. The workshop is to be held in Chapel Hill, N.C., April 22-24, 1991.