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INTERSTITIAL HYPERTHERMIA CURIE PT FERROMAGNETIC SEEDS

间质热疗居里 PT 铁磁种子

基本信息

批准号：
3446676
负责人：
Paul Rath Stauffer
金额：
$ 4.92万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-04-01 至 1988-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3446676
关键词：
microwave radiation neoplasm /cancer thermotherapy phantom model radiation sensitivity

项目摘要

Interstitial brachytherapy is a promising local treatment technique for well contained primary tumors. The problems of radiation necrosis and peripheral recurrence remain unsolved, however. Hyperthermia has been shown to sensitize tumors to radiation, particularly when delivered aggressively concurrent with low dose rate brachytherapy. The research philosophy here is to introduce an effective adjuvant therapy (interstitial thermotherapy) which can increase the radiation response in tumor tissue more than in the surrounding normal tissues. It is anticipated that this thermal enhancement of radiation response in the tumor can lead to reductions in both the required radiation dose for cure as well as the overall complication rate. A 100 kHz Magnetic Induction System will be constructed for heating ferromagnetic seeds which can be inserted in the radiation implant catheters either before, during or after the radiation treatment. The research proposed is to study three-dimensional temperature distributions induced by arrays of ferromagnetic seeds in phantom and animal models. The degree of automatic internal temperature regulation possible with curie point ferromagnetic seed heating will be determined as well as the required number and spacing of temperature sensors to enable efficacious clinical use of this interstitial technique. The relative effectiveness and applicability of ferromagnetic seed heating will be compared to the present interstitial microwave antenna heating technology as a basis for determining future directions for development of hyperthermia equipment technology.

间质近距离放射治疗是一种有前途的局部治疗技术，包含原发性肿瘤。放射性坏死和然而，周围复发仍然没有解决。热疗已经显示肿瘤对辐射敏感，特别是当递送同时进行低剂量率近距离放射治疗。研究这里的理念是引入有效的辅助治疗（间质性热疗法），其可以增加肿瘤组织中的辐射反应比周围正常组织中的多。预计这一肿瘤中辐射反应的热增强可导致降低了固化所需的辐射剂量以及总体并发症发生率。将建造一个100 kHz磁感应系统用于加热可以插入辐射植入物中的铁磁种子在放射治疗之前、期间或之后使用导管。的提出的研究是研究三维温度分布由体模和动物模型中的铁磁种子阵列诱导。的居里温度自动调节的程度点铁磁种子加热将确定以及所需的温度传感器的数量和间距，以实现有效的临床使用这种填隙技术。相对有效性和铁磁种子加热的适用性将与本发明进行比较。间隙微波天线加热技术作为基础，确定热疗设备的未来发展方向技术.