INTERSTITIAL HYPERTHERMIA CURIE PT FERROMAGNETIC SEEDS

组织间近距离放射治疗是一种很有前途的局部治疗技术 很好地控制了原发肿瘤。放射性坏死病和 然而，周围性复发仍未解决。体温过高一直是 被证明能使肿瘤对辐射敏感，尤其是在注射的时候 积极配合低剂量率近距离放射治疗。这项研究 这里的理念是引入一种有效的辅助治疗(间质 热疗)可以增加肿瘤组织的辐射反应 比周围正常组织中更多。预计这将是 肿瘤内辐射反应的热增强可导致 减少治疗所需的辐射剂量以及 总的并发症发生率。 将建造一个100千赫的磁感应系统用于加热 可插入辐射植入物中的铁磁性种子 在放射治疗之前、期间或之后插入导尿管。这个 建议的研究是研究三维温度分布 在体模和动物模型中由铁磁性种子阵列诱导。这个 居里夫人可实现内部温度自动调节的程度 将确定点铁磁种子加热以及所需的 体温传感器的数量和间距，以实现有效的临床 使用这种间隙技术。相对有效性和 铁磁晶种加热的适用性将与现在进行比较 以间隙微波天线加热技术为基础 确定未来热疗设备的发展方向 技术

Interstitial brachytherapy is a promising local treatment technique for well contained primary tumors. The problems of radiation necrosis and peripheral recurrence remain unsolved, however. Hyperthermia has been shown to sensitize tumors to radiation, particularly when delivered aggressively concurrent with low dose rate brachytherapy. The research philosophy here is to introduce an effective adjuvant therapy (interstitial thermotherapy) which can increase the radiation response in tumor tissue more than in the surrounding normal tissues. It is anticipated that this thermal enhancement of radiation response in the tumor can lead to reductions in both the required radiation dose for cure as well as the overall complication rate. A 100 kHz Magnetic Induction System will be constructed for heating ferromagnetic seeds which can be inserted in the radiation implant catheters either before, during or after the radiation treatment. The research proposed is to study three-dimensional temperature distributions induced by arrays of ferromagnetic seeds in phantom and animal models. The degree of automatic internal temperature regulation possible with curie point ferromagnetic seed heating will be determined as well as the required number and spacing of temperature sensors to enable efficacious clinical use of this interstitial technique. The relative effectiveness and applicability of ferromagnetic seed heating will be compared to the present interstitial microwave antenna heating technology as a basis for determining future directions for development of hyperthermia equipment technology.