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Radiometry Controlled Conformal Array Heat Applicator

辐射测量控制的共形阵列热施加器

基本信息

批准号：
7351629
负责人：
Paul Rath Stauffer
金额：
$ 12.29万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-05-15 至 2008-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7351629
关键词：
bioengineering /biomedical engineering clinical biomedical equipment clinical research combination cancer therapy computer program /software evaluation /testing human subject human therapy evaluation microwave radiation neoplasm /cancer radiation therapy neoplasm /cancer thermotherapy phantom model radiation therapy dosage relative biological effectiveness swine

项目摘要

DESCRIPTION (provided by applicant): Adjuvant hyperthermia has been shown effective when sufficiently high thermal doses are delivered in close association with radiation or drug therapies. In previous work, we developed lightweight Conformal microwave Array (CMA) applicators from flexible printed circuit board (PCB) material and 6 mm thick water plus layers for heating large area superficial disease. These applicators were designed for treating chestwall recurrence of breast carcinoma and superficial melanomas <1.5 cm deep, but may eventually find use for treatment of other common skin diseases such as plaque psoriasis. While controllable heating of large contoured areas with CMA applicators has recently become an established IRB-approved procedure at UCSF with excellent heating effectiveness and patient acceptance, more widespread use awaits an improved patient interface that simplifies treatment setup and thermal monitoring/control of the large number of independent heat apertures. Thus, collaborative efforts have completed preliminary development of a microwave radiometer for non-invasive monitoring of subsurface tissue temperature. In this proposal, we plan to optimize the patient interface of current CMA applicators to allow integration of non-invasive temperature monitoring under each independent heat source. Such "Dual Mode" applicators will be characterized in terms of uniformity of power deposition and accuracy of temperature monitoring in chestwall tissue phantoms and comprehensive in vivo temperature distribution measurements in a small number of animals. Finally, applicator functionality in the clinic will be evaluated for improved operator convenience as well as for uniformity of heating, patient tolerance, and toxicity of higher minimum thermal dose treatments. The underlying goal of this development is to rekindle and significantly expand the use of hyperthermia therapy for superficial disease, a treatment that has been proven effective in randomized clinical trials but has stalled awaiting introduction of an easy to use applicator capable of effective heating of small areas with high resolution control, or large areas overlying contoured anatomy. Because of important new capabilities of integrated non-invasive volume-averaged tissue temperature monitoring and automatic self-balancing of applicator output, this applicator should facilitate new clinical protocols with exciting potential for improved therapy of diffuse superficial disease, such as longer duration low level heat in combination with systemic chemotherapy, heat enhanced drug delivery, and heat applied simultaneously with external beam radiation.

描述（由申请人提供）：当足够高的热剂量与放射或药物治疗密切相关时，辅助热疗已被证明是有效的。在之前的工作中，我们利用柔性印刷电路板（PCB）材料和6毫米厚的加水层开发了轻型共形微波阵列（CMA）涂抹器，用于加热大面积浅表疾病。这些涂抹器设计用于治疗胸壁复发的乳腺癌和<1.5厘米深的浅表黑色素瘤，但最终可能用于治疗其他常见的皮肤疾病，如斑块性牛皮癣。虽然最近使用CMA涂抹器对大面积轮廓区域进行可控加热已成为UCSF建立的irb批准的程序，具有出色的加热效果和患者接受度，但更广泛的应用需要改进患者界面，简化治疗设置和大量独立热孔的热监测/控制。因此，合作努力已经完成了微波辐射计的初步开发，用于非侵入性监测地下组织温度。在本提案中，我们计划优化当前CMA涂抹器的患者界面，以便在每个独立热源下集成非侵入性温度监测。这种“双模式”应用器的特点是功率沉积的均匀性和胸壁组织模型温度监测的准确性，以及对少数动物体内温度分布的全面测量。最后，将评估临床应用器的功能，以改善操作人员的便利性，以及加热的均匀性，患者的耐受性和更高最小热剂量治疗的毒性。这一发展的潜在目标是重新点燃并显著扩大热疗治疗浅表疾病的使用，这种治疗方法在随机临床试验中已被证明是有效的，但一直停滞不前，等待一种易于使用的涂抹器的引入，这种涂抹器能够在高分辨率控制下有效加热小区域，或大面积覆盖轮廓解剖。由于集成的非侵入性体积平均组织温度监测和自动自平衡喷雾器输出的重要新功能，该喷雾器应该促进新的临床方案，具有令人兴奋的潜力，可以改善弥漫性浅表疾病的治疗，例如长时间低水平热与全身化疗联合，热增强药物输送，热与外部束辐射同时应用。

项目成果

期刊论文数量（24）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Development of a hybrid process and system model for the assessment of wellbore leakage at a geologic CO2 sequestration site.

DOI：
10.1021/es800417x
发表时间：
2008-08
期刊：
Environmental science & technology
影响因子：
11.4
作者：
H. Viswanathan;R. Pawar;P. Stauffer;J. Kaszuba;J. Carey;S. Olsen;G. Keating;D. Kavetski;G. Guthrie
通讯作者：
H. Viswanathan;R. Pawar;P. Stauffer;J. Kaszuba;J. Carey;S. Olsen;G. Keating;D. Kavetski;G. Guthrie

Design of spiral antennas for radiometric temperature measurement.

用于辐射温度测量的螺旋天线设计。