INTERSTITIAL HYPERTHERMIA CURIE PT FERROMAGNETIC SEEDS

间质热疗居里 PT 铁磁种子

• 批准号: 3446675
• 负责人: Paul Rath Stauffer
• 金额: $ 4.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3446675
• 关键词: microwave radiation; neoplasm /cancer thermotherapy; phantom model; radiation sensitivity

Interstitial brachytherapy is a promising local treatment technique for well contained primary tumors. The problems of radiation necrosis and peripheral recurrence remain unsolved, however. Hyperthermia has been shown to sensitize tumors to radiation, particularly when delivered aggressively concurrent with low dose rate brachytherapy. The research philosophy here is to introduce an effective adjuvant therapy (interstitial thermotherapy) which can increase the radiation response in tumor tissue more than in the surrounding normal tissues. It is anticipated that this thermal enhancement of radiation response in the tumor can lead to reductions in both the required radiation dose for cure as well as the overall complication rate. A 100 kHz Magnetic Induction System will be constructed for heating ferromagnetic seeds which can be inserted in the radiation implant catheters either before, during or after the radiation treatment. The research proposed is to study three-dimensional temperature distributions induced by arrays of ferromagnetic seeds in phantom and animal models. The degree of automatic internal temperature regulation possible with curie point ferromagnetic seed heating will be determined as well as the required number and spacing of temperature sensors to enable efficacious clinical use of this interstitial technique. The relative effectiveness and applicability of ferromagnetic seed heating will be compared to the present interstitial microwave antenna heating technology as a basis for determining future directions for development of hyperthermia equipment technology.

间质近距离放射治疗是一种有前途的局部治疗技术 原发肿瘤控制良好。 放射性坏死问题 然而，外周复发仍未解决。 高热已 研究显示肿瘤对辐射敏感，尤其是在分娩时 积极与低剂量率近距离放射治疗同时进行。 研究 这里的理念是引入一种有效的辅助疗法（间质疗法） 热疗法）可以增加肿瘤组织的放射反应 多于周围正常组织。 预计这 肿瘤中辐射反应的热增强可导致 减少治疗所需的辐射剂量以及 总体并发症发生率。 将建造一个 100 kHz 磁感应系统用于加热 可以插入辐射植入物中的铁磁种子 在放射治疗之前、期间或之后放置导管。 这 提出的研究是研究三维温度分布 在模型和动物模型中由铁磁种子阵列诱导。 这 居里自动内部温度调节程度 点铁磁种子加热将被确定以及所需的 温度传感器的数量和间距，以实现有效的临床 使用这种间隙技术。 相对有效性和 铁磁种子加热的适用性将与现有技术进行比较 以间隙微波天线加热技术为基础 确定热疗设备未来的发展方向 技术。