Radiometry Controlled Conformal Array Heat Applicator

辐射测量控制的共形阵列热施加器

• 批准号: 7012293
• 负责人: Paul Rath Stauffer
• 金额: $ 7.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-15 至 2006-06-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7012293
• 关键词: bioengineering /biomedical engineering; clinical biomedical equipment; clinical research; combination cancer therapy; computer program /software; evaluation /testing; human subject; human therapy evaluation; microwave radiation; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; phantom model; radiation therapy dosage; relative biological effectiveness; swine

DESCRIPTION (provided by applicant): Adjuvant hyperthermia has been shown effective when sufficiently high thermal doses are delivered in close association with radiation or drug therapies. In previous work, we developed lightweight Conformal microwave Array (CMA) applicators from flexible printed circuit board (PCB) material and 6 mm thick water plus layers for heating large area superficial disease. These applicators were designed for treating chestwall recurrence of breast carcinoma and superficial melanomas <1.5 cm deep, but may eventually find use for treatment of other common skin diseases such as plaque psoriasis. While controllable heating of large contoured areas with CMA applicators has recently become an established IRB-approved procedure at UCSF with excellent heating effectiveness and patient acceptance, more widespread use awaits an improved patient interface that simplifies treatment setup and thermal monitoring/control of the large number of independent heat apertures. Thus, collaborative efforts have completed preliminary development of a microwave radiometer for non-invasive monitoring of subsurface tissue temperature. In this proposal, we plan to optimize the patient interface of current CMA applicators to allow integration of non-invasive temperature monitoring under each independent heat source. Such "Dual Mode" applicators will be characterized in terms of uniformity of power deposition and accuracy of temperature monitoring in chestwall tissue phantoms and comprehensive in vivo temperature distribution measurements in a small number of animals. Finally, applicator functionality in the clinic will be evaluated for improved operator convenience as well as for uniformity of heating, patient tolerance, and toxicity of higher minimum thermal dose treatments. The underlying goal of this development is to rekindle and significantly expand the use of hyperthermia therapy for superficial disease, a treatment that has been proven effective in randomized clinical trials but has stalled awaiting introduction of an easy to use applicator capable of effective heating of small areas with high resolution control, or large areas overlying contoured anatomy. Because of important new capabilities of integrated non-invasive volume-averaged tissue temperature monitoring and automatic self-balancing of applicator output, this applicator should facilitate new clinical protocols with exciting potential for improved therapy of diffuse superficial disease, such as longer duration low level heat in combination with systemic chemotherapy, heat enhanced drug delivery, and heat applied simultaneously with external beam radiation.

描述（由申请人提供）：当足够高的热剂量与放射线或药物疗法密切相关时，佐剂高温已显示出有效。在先前的工作中，我们从柔性印刷电路板（PCB）材料和6毫米厚的水加上层的轻巧的保形微波阵列（CMA）涂抹器，用于加热大面积浅层疾病。这些涂药者的设计用于治疗乳腺癌的胸壁复发和浅黑色素瘤<1.5 cm的深度，但最终可能会发现用于治疗其他常见的皮肤病，例如斑块牛皮癣。尽管使用CMA涂抹器对大型轮廓区域的可控加热最近已成为UCSF的一项已建立的IRB批准的程序，具有出色的供暖有效性和患者的接受度，但更广泛的使用量正在等待改进的患者界面，可简化治疗设置和热量的热量监测/控制大量独立热射击。因此，协作工作已经完成了微波辐射仪的初步开发，用于非侵入性监测地下组织温度。在此提案中，我们计划优化当前CMA涂药器的患者界面，以允许在每个独立的热源下整合非侵入性温度监测。这种“双模式”的涂抹器将以功率沉积的均匀性和胸壁组织幻像的温度监测的准确性以及少数动物的体内温度分布测量的全面表征来表征。最后，将评估诊所中的施用器功能，以提高操作员的便利性以及加热，患者耐受性和较高最低热剂量治疗的毒性的均匀性。这一发展的根本目标是重新燃烧并显着扩展使用高温治疗对浅表疾病的使用，该治疗在随机临床试验中已被证明有效，但已停滞不前等待易于使用易于使用的施用者，能够有效地供应具有高分辨率控制的小区域，或者是大区域的大面积控制，或者是大面积的大面积。由于重要的非侵入性体积平均组织温度监测和涂抹器输出的自动自动平衡的新功能，该涂抹器应促进新的临床方案，具有改善弥漫性表面疾病治疗的令人兴奋的潜力，例如在与全身性化学疗法相结合的情况下，持续时间更长的持续时间低水平的热量，与全身性化学疗法相结合，加热药物的同步和置于同步型，并散发出热度的散布。