Radiometry Controlled Conformal Array Heat Applicator

辐射测量控制的共形阵列热施加器

• 批准号: 7012293
• 负责人: Paul Rath Stauffer
• 金额: $ 7.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-15 至 2006-06-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7012293
• 关键词: bioengineering /biomedical engineering; clinical biomedical equipment; clinical research; combination cancer therapy; computer program /software; evaluation /testing; human subject; human therapy evaluation; microwave radiation; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; phantom model; radiation therapy dosage; relative biological effectiveness; swine

DESCRIPTION (provided by applicant): Adjuvant hyperthermia has been shown effective when sufficiently high thermal doses are delivered in close association with radiation or drug therapies. In previous work, we developed lightweight Conformal microwave Array (CMA) applicators from flexible printed circuit board (PCB) material and 6 mm thick water plus layers for heating large area superficial disease. These applicators were designed for treating chestwall recurrence of breast carcinoma and superficial melanomas <1.5 cm deep, but may eventually find use for treatment of other common skin diseases such as plaque psoriasis. While controllable heating of large contoured areas with CMA applicators has recently become an established IRB-approved procedure at UCSF with excellent heating effectiveness and patient acceptance, more widespread use awaits an improved patient interface that simplifies treatment setup and thermal monitoring/control of the large number of independent heat apertures. Thus, collaborative efforts have completed preliminary development of a microwave radiometer for non-invasive monitoring of subsurface tissue temperature. In this proposal, we plan to optimize the patient interface of current CMA applicators to allow integration of non-invasive temperature monitoring under each independent heat source. Such "Dual Mode" applicators will be characterized in terms of uniformity of power deposition and accuracy of temperature monitoring in chestwall tissue phantoms and comprehensive in vivo temperature distribution measurements in a small number of animals. Finally, applicator functionality in the clinic will be evaluated for improved operator convenience as well as for uniformity of heating, patient tolerance, and toxicity of higher minimum thermal dose treatments. The underlying goal of this development is to rekindle and significantly expand the use of hyperthermia therapy for superficial disease, a treatment that has been proven effective in randomized clinical trials but has stalled awaiting introduction of an easy to use applicator capable of effective heating of small areas with high resolution control, or large areas overlying contoured anatomy. Because of important new capabilities of integrated non-invasive volume-averaged tissue temperature monitoring and automatic self-balancing of applicator output, this applicator should facilitate new clinical protocols with exciting potential for improved therapy of diffuse superficial disease, such as longer duration low level heat in combination with systemic chemotherapy, heat enhanced drug delivery, and heat applied simultaneously with external beam radiation.

描述（由申请人提供）：当与放射或药物治疗密切相关地输送足够高的热剂量时，辅助热疗已被证明是有效的。在之前的工作中，我们利用柔性印刷电路板 (PCB) 材料和 6 毫米厚的水加层开发了轻型共形微波阵列 (CMA) 涂抹器，用于加热大面积浅表疾病。这些涂药器设计用于治疗乳腺癌的胸壁复发和深度<1.5厘米的浅表黑色素瘤，但最终可能用于治疗其他常见皮肤病，例如斑块状银屑病。虽然使用 CMA 涂抹器对大轮廓区域进行可控加热最近已成为 UCSF 的 IRB 批准的既定程序，具有出色的加热效率和患者接受度，但更广泛的应用有待改进的患者界面，以简化治疗设置和对大量独立热孔的热监测/控制。因此，合作努力已经完成了用于非侵入性监测地下组织温度的微波辐射计的初步开发。在此提案中，我们计划优化当前 CMA 施放器的患者界面，以允许在每个独立热源下集成无创温度监测。这种“双模式”施加器的特点是功率沉积的均匀性和胸壁组织模型中温度监测的准确性以及少量动物体内全面的体内温度分布测量。最后，将评估诊所中的涂药器功能，以提高操作者的便利性以及加热的均匀性、患者耐受性和较高最小热剂量治疗的毒性。这一开发的根本目标是重新启动并显着扩大热疗疗法对浅表疾病的使用，这种治疗方法已在随机临床试验中被证明有效，但在等待推出一种易于使用的涂抹器，能够有效加热具有高分辨率控制的小区域或覆盖轮廓解剖结构的大区域时，已陷入停滞。由于集成非侵入性体积平均组织温度监测和施源器输出自动自平衡的重要新功能，该施源器应促进新的临床方案，具有改善弥漫性浅表疾病治疗的令人兴奋的潜力，例如较长持续时间的低水平热结合全身化疗、热增强药物输送以及与外部束辐射同时施加的热。