Radiometry Controlled Conformal Array Heat Applicator

辐射测量控制的共形阵列热施加器

• 批准号: 6868167
• 负责人: Paul Rath Stauffer
• 金额: $ 20.86万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-15 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6868167
• 关键词: bioengineering /biomedical engineering; clinical biomedical equipment; clinical research; combination cancer therapy; computer program /software; evaluation /testing; human subject; human therapy evaluation; microwave radiation; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; phantom model; radiation therapy dosage; relative biological effectiveness; swine

DESCRIPTION (provided by applicant): Adjuvant hyperthermia has been shown effective when sufficiently high thermal doses are delivered in close association with radiation or drug therapies. In previous work, we developed lightweight Conformal microwave Array (CMA) applicators from flexible printed circuit board (PCB) material and 6 mm thick water plus layers for heating large area superficial disease. These applicators were designed for treating chestwall recurrence of breast carcinoma and superficial melanomas <1.5 cm deep, but may eventually find use for treatment of other common skin diseases such as plaque psoriasis. While controllable heating of large contoured areas with CMA applicators has recently become an established IRB-approved procedure at UCSF with excellent heating effectiveness and patient acceptance, more widespread use awaits an improved patient interface that simplifies treatment setup and thermal monitoring/control of the large number of independent heat apertures. Thus, collaborative efforts have completed preliminary development of a microwave radiometer for non-invasive monitoring of subsurface tissue temperature. In this proposal, we plan to optimize the patient interface of current CMA applicators to allow integration of non-invasive temperature monitoring under each independent heat source. Such "Dual Mode" applicators will be characterized in terms of uniformity of power deposition and accuracy of temperature monitoring in chestwall tissue phantoms and comprehensive in vivo temperature distribution measurements in a small number of animals. Finally, applicator functionality in the clinic will be evaluated for improved operator convenience as well as for uniformity of heating, patient tolerance, and toxicity of higher minimum thermal dose treatments. The underlying goal of this development is to rekindle and significantly expand the use of hyperthermia therapy for superficial disease, a treatment that has been proven effective in randomized clinical trials but has stalled awaiting introduction of an easy to use applicator capable of effective heating of small areas with high resolution control, or large areas overlying contoured anatomy. Because of important new capabilities of integrated non-invasive volume-averaged tissue temperature monitoring and automatic self-balancing of applicator output, this applicator should facilitate new clinical protocols with exciting potential for improved therapy of diffuse superficial disease, such as longer duration low level heat in combination with systemic chemotherapy, heat enhanced drug delivery, and heat applied simultaneously with external beam radiation.

描述（由申请人提供）：当足够高的热剂量与放射或药物治疗密切相关时，辅助热疗已被证明是有效的。在之前的工作中，我们使用柔性印刷电路板（PCB）材料和6 mm厚的水加层开发了轻型共形微波阵列（CMA）施加器，用于加热大面积表面疾病。这些敷贴器设计用于治疗乳腺癌和深度<1.5 cm的浅表性黑色素瘤的胸壁复发，但最终可能用于治疗其他常见皮肤病，如斑块状银屑病。虽然使用CMA施源器对大轮廓区域进行可控加热最近已成为UCSF的IRB批准的程序，具有出色的加热效果和患者接受度，但更广泛的使用有待改进的患者界面，该界面简化了治疗设置和大量独立热孔的热监测/控制。因此，协作努力已经完成了初步开发的微波辐射计的非侵入性监测皮下组织的温度。在本提案中，我们计划优化当前CMA施源器的患者界面，以允许在每个独立热源下集成无创温度监测。这种“双模式”施加器的特征在于功率沉积的均匀性和胸壁组织模型中温度监测的准确性以及少量动物中的全面体内温度分布测量。最后，将评价临床中的施源器功能，以改善操作员便利性以及加热均匀性、患者耐受性和较高最小热剂量治疗的毒性。该开发的根本目标是重新点燃并显著扩大用于浅表疾病的热疗治疗的使用，该治疗在随机临床试验中已被证明是有效的，但已停滞，等待引入易于使用的施用器，该施用器能够有效加热具有高分辨率控制的小区域或覆盖轮廓解剖结构的大区域。由于集成的非侵入性体积平均组织温度监测和施加器输出的自动自平衡的重要新功能，该施加器应促进新的临床方案，具有改善弥漫性浅表疾病治疗的令人兴奋的潜力，例如与全身化疗相结合的较长持续时间的低水平热，热增强药物输送，以及与外部射束辐射同时施加的热。