DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES

要求提供赠款资金，以改善24，000净的动物设施 平方英尺的住房和支持空间，一直保持AAALAC 自1977年以来的认证。 计划的改建和设备 购买这些设备可以更换勉强够用的高压灭菌器; 将扩大现有能力， 微隔离笼和用品;并将鼓励增加 在需要严格保护啮齿动物的研究中使用微隔离器 从外来病原体。 还提出了修改， 将非功能区改为额外的空间，用于手术，动物饲养， 和实验性手术目的。 其他的翻新是为了 升级空间专门用于啮齿动物研究，需要高水平的 隔离 执行这些计划将有助于确保 住房、畜牧业和动物的使用正在跟上快速增长的步伐。 科学知识和研究技术的变化。 这些改进的需要是由于 该机构的研究和研究培训的校外奖励 涉及实验室动物。 校外动物研究的增加 从1985财年的840万美元和91个项目增加到1440万美元和107个项目 在1988财政年度，增加了对额外能力的需求， 将动物保持在精心控制的环境中， 空间、设备和支持服务。 在过去五年中， 动物设施涉及380万美元的投资， 机构。 所设想的改进是一个重要阶段， 设施开发。 为了满足额外教师的需求， 聘请，大学正在建设一个新的医学研究大楼， 将在1992年被占用，将提供额外的30-35个动物室 对于各种各样的物种来说。

Grant funds are requested to improve an animal facility of 24,000 net square feet of housing and support space that has maintained AAALAC accreditation since 1977. The planned alterations and equipment purchases would permit replacement of a marginally adequate autoclave; would expand present capacity to provide investigators with sterilized microisolator cages and supplies; and would encourage increased microisolator use in studies that require strict protection of rodents from adventitious pathogens. Also proposed are alterations to transform a non-functional area into added space for procedure, animal holding, and experimental surgery purposes. Other renovations are intended to upgrade space dedicated to rodent research requiring a high level of isolation. Implementation of these plans would help to ensure that housing, husbandry and use of animals are keeping pace with rapid changes in scientific knowledge and research technology. The need for these improvements arises from a substantial growth in extramural awards to this institution for research and research training involving laboratory animals. An increase in extramural animal research from $8.4M and 91 projects in Fiscal Year 1985 to 14.4M and 107 projects in Fiscal Year 1988 has heightened demand for additional capacity to maintain animals in carefully controlled environments and for additional space, equipment, and support services. Over the past five years, capital expenditures for the centralized animal facility have involved a $3.8 million investment by the institution. The contemplated improvements represent an important phase facility development. To meet the needs of additional faculty to be hired, the University is constructing a new medical research building to be occupied in 1992 that will provide an additional 30-35 animal rooms for a variety of species.