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IRON DEFICIENCY ANEMIA AND INFANT BEHAVIOR

缺铁性贫血和婴儿行为

基本信息

批准号：
3565535
负责人：
BETSY LOZOFF
金额：
$ 24.73万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1980
资助国家：
美国
起止时间：
1980-09-01 至 1990-06-30
项目状态：
已结题

项目摘要

The present proposal requests an additional year of support to complete an ongoing project as originally planned. The research seeks to determine 1) if behavioral and developmental abnormalities associated with iron deficiency anemia during infancy can be corrected with extended iron therapy and 2) if deficits persists in school-aged children who had iron deficiency anemia as infants has been 30% lower than projected, an additional year is needed to enroll the required sample and achieve the project's first goal. Recent studies have found that infants with iron deficiency anemia obtain lower mental and motor test scores than nonanemic controls and that the majority of anemic infants do not show improvement in test scores, even though their anemia is corrected after 2-3 months of iron therapy. to pursue these findings, two studies are in progress. Study I, which will require another year to complete, is a double-blind randomized controlled study of extended iron therapy in infancy. 90 one- to two-year-old infants will be studied: 30 iron deficient anemic infants, matched by age and sex with 30 nonanemic placebo-treated controls and 30 nonanemic iron-treated controls. their behavior and development are being assessed before and after both three and six months of oral iron therapy. The study also provides an opportunity to confirm the specific patten of limitations, observed among iron deficient anemic infants in previous projects. There are two major possible outcomes of the study: 1) an extended course of iron therapy will correct developmental and behavioral abnormalities n iron deficient anemic infants, a result that would require a major reformulation of current recommendations about iron therapy and monitoring of therapeutic response in infants or 2) pretreatment deficits will persist in iron deficient anemic infants despite extended treatment, indicating that, depending on chronicity, severity, or timing, iron deficiency anemia in infancy may have irreversible effects. In Study II all 191 children in the previous cohort are being reassessed at five years of age using psychoeducational, neurological, motor, and behavioral measures that focus on the specific functions that were identified as impaired in our previous two studies. The proposed research will determine the long-term cognitive, motor, and behavioral sequelae of iron deficiency anemia in infancy and the effects of treatment in a group of children that has already been exceptionally well characterized.

本提案要求再提供一年的支助，按原计划进行的项目。该研究旨在确定1）是否与行为和发育异常相关婴儿期缺铁性贫血可以通过延长铁治疗和2）如果赤字持续在学龄儿童谁有婴儿缺铁性贫血的发病率比预期低30%，需要额外一年的时间来招募所需的样本，并实现项目的第一个目标。最近的研究发现，缺乏性贫血的智力和运动测试得分低于非贫血对照组和大多数贫血婴儿不显示改善测试成绩，即使他们的贫血是纠正后， 2-3几个月的铁剂治疗为了进一步研究这些发现，中求进工作总研究一需要一年时间才能完成，一项双盲随机对照研究，婴儿期。将对90名1至2岁的婴儿进行研究：30铁缺乏性贫血婴儿，年龄和性别匹配，30名非贫血安慰剂治疗的对照和30个非贫血性铁治疗的对照。他们的行为和发展正在评估之前和之后，这三个和六个月的口服铁剂治疗该研究还提供了有机会确认具体的限制模式，缺铁性贫血的婴儿在以前的项目。有两大研究的可能结果：1）延长铁剂治疗疗程将纠正发育和行为异常n缺铁贫血的婴儿，结果将需要一个重大的重新制定目前关于铁治疗和治疗监测的建议或2）治疗前铁缺乏将持续存在缺乏贫血的婴儿，尽管延长治疗，表明，根据慢性程度、严重程度或时间，婴儿期可能有不可逆转的影响。在研究II中，前一组在5岁时重新评估，心理教育，神经，运动和行为措施，专注于在我们的研究中被确定为受损的特定功能，前两项研究。这项研究将决定长期缺铁性贫血的认知、运动和行为后遗症婴儿期和治疗的影响，在一组儿童，已经被非常好地描述了。