Clinical Infrared and Raman Spectroscopy Network (CLIRSPEC)

临床红外和拉曼光谱网络 (CLIRSPEC)

• 批准号: EP/L012952/1
• 负责人: Peter Gardner
• 金额: $ 24.01万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FL012952%2F1
• 关键词: Clinical; Infrared; Raman; Spectroscopy; Network

A major part of the diagnosis of any disease but particularly various forms of cancer, is obtained though a biopsy. This involves removing a small sample of tissue, or a few cells, from the patient. These samples, either tissue or cells are then examined by a pathologist looking down an optical microscope. In most cases the sample is stained with a combination of dyes to help gain some contrast. In most cases, based upon visual inspection of the sample a diagnosis is made. This process if far from ideal since it relies on the expertise of the clinician concerned as is subject to intra in inter observer error. Recently a number of proof of concept studies have shown that molecular spectroscopic techniques such as infrared and Raman are capable of distinguishing diseased from non diseased cells and tissue based upon the inherent chemistry contained within the cells. The UK is at the forefront of these developments but there are many hurdles that need to be overcome if this technology is to move from the proof of concept stage through the translational stage and into the clinical setting. It is the belief of the academic community that we are much more likely to overcome these hurdles if we pool our resources, bring in both industrial and clinical partners and work on these generic problems together. This application is for funding to support such a network of partners for the next three years.

任何疾病，特别是各种形式的癌症的诊断的主要部分是通过活检获得的。这涉及从患者身上取出一小块组织样本或几个细胞。这些样本，无论是组织或细胞，然后由病理学家向下观察光学显微镜检查。在大多数情况下，样品用染料的组合染色，以帮助获得一些对比度。在大多数情况下，基于对样品的目视检查进行诊断。该过程远不理想，因为它依赖于相关临床医生的专业知识，因为会受到观察者间误差的影响。最近，许多概念验证研究表明，分子光谱技术如红外和拉曼能够基于细胞内包含的固有化学将患病细胞和组织与非患病细胞和组织区分开。英国处于这些发展的最前沿，但如果这项技术要从概念验证阶段进入转化阶段并进入临床环境，则需要克服许多障碍。学术界认为，如果我们集中资源，引入工业和临床合作伙伴，共同解决这些一般性问题，我们更有可能克服这些障碍。该申请旨在为未来三年的合作伙伴网络提供资金支持。

项目成果

Comparison of transmission and transflectance mode FTIR imaging of biological tissue.

• DOI: 10.1039/c4an01975j
• 发表时间: 2015-03
• 期刊: The Analyst
• 作者: M. Pilling;P. Bassan;P. Gardner

Introducing Discrete Frequency Infrared Technology for High-Throughput Biofluid Screening.

• DOI: 10.1038/srep20173
• 发表时间: 2016-02-04
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Hughes C;Clemens G;Bird B;Dawson T;Ashton KM;Jenkinson MD;Brodbelt A;Weida M;Fotheringham E;Barre M;Rowlette J;Baker MJ
• 通讯作者: Baker MJ