EPIDEMIOLOGY OF SALIVARY GLAND CANCER

将开展以人群为基础的病例对照流行病学研究 调查与唾液腺发病率相关的危险因素 癌症。10月间确诊的涎腺癌病例 1990年1日和1993年12月31日，将通过快速案件进行鉴定 在其中两个组织的主持下建立的查明系统 加州肿瘤登记处区域登记处。这些案件，谁来编号？ 大约285个，将与选择的相同数量的控件进行比较 从普通人群中随机抽取，并与 五岁年龄组的基数。20岁的控制组-将被确定 通过随机数字拨号过程。65-79岁的控制者将是 通过卫生保健财务管理局的记录确定。 电话访问将使用结构化问卷进行 由训练有素的采访者管理。调查问卷将包括 项目包括外源性暴露、病史和选定的饮食，k 生活方式和社会人口因素。一篇独立的病理学综述 将进行统一的组织学分类，并 有既往病史时，区分原发癌和转移癌 癌症的威胁。将在#年进行多元Logistic回归分析 为了评估每个因素的影响，同时考虑所有其他因素 考虑并评估修改的效果。结果应该是 阐明与本病相关的鲜为人知的病因 涎腺癌的发展和有助于解释最近的 观察到这些癌症的发病率不断上升。

A population-based case-control epidemiologic study will be conducted to investigate risk factors associated with the incidence of salivary gland cancer. Incident cases of salivary gland cancer, diagnosed between October 1, 1990 and December 31, 1993, will be identified through rapid case ascertainment systems established under the auspices of two of the California Tumor Registry regional registries. The cases, who will number approximately 285, will be compared to an equal number of controls selected randomly from the general population and frequency-matched to the cases on the basis of five-year age groups. Controls age 20-64 will be identified through random-digit dialing processes. Controls age 65-79 will be identified through the records of the Health Care Finance Administration. Telephone interviews will be conducted using a structured questionnaire administered by a trained interviewer. The questionnaire will include items covering exogenous exposures, medical history, and selected dietary,k lifestyle, and sociodemographic factors. An independent pathology review will be conducted to provide a uniform histologic classification and to distinguish primary cancers from metastases when there is a prior history of cancer. Multiple logistic regression analyses will be performed in order to assess the effects of each factor while taking all other factors into account and to assess effect modification. The results should elucidate the little known etiologic factors associated with the development of salivary gland cancer and help to explain the recently observed increasing incidence of these cancers.