Nutrition and Thyroid Cancer Risk in the CTS Cohort

CTS 队列中的营养和甲状腺癌风险

• 批准号: 7214240
• 负责人: PAMELA L HORN-ROSS
• 金额: $ 7.25万
• 依托单位: CANCER PREVENTION INSTIT OF CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-19 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7214240
• 关键词: cancer risk; clinical research; insulin; neoplasm /cancer; nutrition; thyroid neoplasm

DESCRIPTION (provided by applicant): Over the past 10 years, the incidence of thyroid cancer in women has been increasing faster than any other cancer in either women or men. Yet its causes are still largely unknown, although several promising avenues related to nutrition have emerged. The proposed study will use previously collected, prospective data to verify and expand on these findings. In addition, we will address an emerging hypothesis regarding the impact of insulin on thyroid cancer risk. Our specific aims are: (1) to evaluate the relationship between papillary thyroid cancer risk and (a) cruciferous vegetables and isothiocyanates, using a newly developed database, and (b) overall and abdominal adiposity; and (2) to evaluate the association between papillary thyroid cancer risk and dietary factors that are (a) positively related to insulin levels (i.e., refined grains and glycemic load) and (b) inversely related to insulin levels (i.e., whole grains and fiber). These analyses will take place in the context of the California Teachers Study (CTS) and include 117,646 women. Over a ten- year follow-up period (through December 31, 2005), it is anticipated that 154 cases of papillary thyroid cancer will be diagnosed within this cohort. Cancer cases are identified through annual linkage with the California Cancer Registry (CCR) and are over 99% complete. Cohort follow-up for vital status and continued California residence is accomplished through contact with participants and linkage with various databases. Usual dietary intake was assessed at baseline using a validated food-frequency questionnaire. Height and weight were self-reported at baseline and waist and hip circumferences self-measured at the first follow-up; these measurements have also been validated against interviewer measurements in a subsample of the cohort. Cox proportional hazards models with age as the time scale and adjusting for birth cohort will be used to calculate relative risks. The results of this research will have important implications for improving our understanding of the etiology of this disease which disproportionately affects young women.

描述（由申请人提供）：在过去的10年里，女性甲状腺癌的发病率比男性和女性中任何其他癌症的发病率增长都要快。尽管已经出现了一些与营养有关的有希望的途径，但其原因在很大程度上仍然未知。拟议的研究将使用先前收集的前瞻性数据来验证和扩展这些发现。此外，我们将讨论一个关于胰岛素对甲状腺癌风险影响的新兴假设。我们的具体目标是：(1)评估乳头状甲状腺癌风险与(a)十字花科蔬菜和异硫氰酸酯之间的关系，使用新开发的数据库，以及(b)整体和腹部肥胖；(2)评估甲状腺乳头状癌风险与(a)与胰岛素水平正相关（即精制谷物和血糖负荷）和(b)与胰岛素水平负相关（即全谷物和纤维）的饮食因素之间的关系。这些分析将在加州教师研究（CTS）的背景下进行，包括117,646名女性。在10年的随访期间（至2005年12月31日），预计在该队列中将诊断出154例乳头状甲状腺癌。癌症病例是通过与加州癌症登记处（CCR）的年度联系确定的，完成率超过99%。通过与参与者的联系和与各种数据库的联系，完成了重要状态和继续在加州居住的队列随访。在基线时使用有效的食物频率问卷评估日常饮食摄入量。基线时自我报告身高和体重，第一次随访时自我测量腰围和臀围；这些测量也已经在队列的子样本中与采访者测量进行了验证。以年龄为时间尺度并对出生队列进行调整的Cox比例风险模型计算相对风险。这项研究的结果将对提高我们对这种疾病的病因的理解具有重要意义，这种疾病对年轻女性的影响尤为严重。