PHYTOESTROGENS AND BREAST CANCER--NUTRIENT ANALYSIS

植物雌激素与乳腺癌——营养分析

• 批准号: 2443267
• 负责人: PAMELA L HORN-ROSS
• 金额: $ 3.05万
• 依托单位: CANCER PREVENTION INSTIT OF CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-16 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2443267
• 关键词: African American; Hispanic Americans; Leguminoseae; breast neoplasms; cancer prevention; cancer risk; caucasian American; clinical research; data collection methodology /evaluation; dietary constituent; dietary fiber; estrogens; female; genistein; high performance liquid chromatography; human data; mass spectrometry; nutrition aspect of cancer; nutrition related neoplasm /cancer; nutrition related tag; questionnaires; women's health

DESCRIPTION: (Applicant's Description) Greater consumption of phytoestrogens (i.e., weak estrogens of plant derivation) has been hypothesized to reduce breast cancer risk through the antiestrogenic effects of these compounds. However, the epidemiologic data addressing this relationship is limited with most studies concentrating on soy-based products. We recently began a population-based case-control study examining the relationship between non-soy sources of phytoestrogens and breast cancer risk in white, African American, and Latina women. To develop the dietary assessment instrument for this study we are collecting information on the varieties, sources, and preparation practices of beans and other potentially important sources of phytoestrogens through semistructured interviews with 140 women. However, to make the greatest contribution to understanding this etiologic relationship, more extensive data on the phytoestrogen content of foods is necessary. Thus, we propose here to utilize the data from our semistructuted interviews to identify foods and dishes to be tested for the content of seven specific phytoestrogens using state-of-the-art mass spectrometry techniques. These phytoestrogen levels will be incorporated into the nutrient database being used in the ongoing case-control study allowing us to address this important etiologic question with greater specificity, i.e., by directly examining the effects of the individual phytoestrogens and assessing these effects in conjunction with other components of phytoestrogen-rich foods, such as fiber and antioxidant vitamins.

描述：（申请人的描述）更多的消耗 植物雌激素（即植物来源的弱雌激素）已被 假设通过抗雌激素作用降低乳腺癌风险 这些化合物。 然而，针对这一问题的流行病学数据 大多数研究都集中在以大豆为基础的研究上，这种关系是有限的 产品。 我们最近开始了一项基于人群的病例对照研究 非大豆来源的植物雌激素与乳腺癌之间的关系 白人、非裔美国人和拉丁裔女性的风险。 制定饮食方案 我们正在收集有关本研究的评估工具的信息 豆类和其他潜在的品种、来源和制备方法 通过半结构化访谈了解植物雌激素的重要来源 140 名女性。 然而，为理解这一点做出最大的贡献 病因关系，有关植物雌激素含量的更广泛数据 食物是必要的。 因此，我们在这里建议利用我们的数据 半结构化访谈，以确定要测试的食物和菜肴 使用最先进的质量测定七种特定植物雌激素的含量 光谱测定技术。 这些植物雌激素水平将被纳入 进入正在进行的病例对照研究中使用的营养数据库 使我们能够更好地解决这个重要的病因学问题 特异性，即通过直接检查个体的影响 植物雌激素并与其他药物一起评估这些影响 富含植物雌激素的食物成分，例如纤维和抗氧化剂 维生素。