Nutrition and Thyroid Cancer Risk in the CTS Cohort

CTS 队列中的营养和甲状腺癌风险

• 批准号: 7288271
• 负责人: PAMELA L HORN-ROSS
• 金额: $ 7.04万
• 依托单位: CANCER PREVENTION INSTIT OF CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-19 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7288271
• 关键词: Address; Affect; Age; Birth; California; Case-Control Studies; Cereals; Cohort Studies; Consumption; Cox Proportional Hazards Models; Data; Databases; Diagnosis; Diet; Dietary Component; Dietary Factors; Dietary Fiber; Dietary intake; Ethnic group; Etiology; Fiber; Food; Frequencies; Glycemic Index; Height; Heterogeneity; Hip region structure; Incidence; Insulin; Interviewer; Isothiocyanates; Malignant Neoplasms; Malignant neoplasm of ovary; Malignant neoplasm of thyroid; Measurement; Measures; Metabolic Pathway; Non-Hodgkin' s Lymphoma; Obesity; Papillary thyroid carcinoma; Participant; Patient Self-Report; Population; Questionnaires; Rate; Relative Risks; Reporting; Research; Risk; Risk Factors; Thyroid Gland; Thyroid carcinoma; Time; Today; Vital Status; Weight; Woman; abdominal fat; base; cancer risk; carcinogenesis; cohort; cruciferous vegetable; follow-up; improved; melanoma; men; neoplasm registry; nutrition; prospective; residence; size; teacher

DESCRIPTION (provided by applicant): Over the past 10 years, the incidence of thyroid cancer in women has been increasing faster than any other cancer in either women or men. Yet its causes are still largely unknown, although several promising avenues related to nutrition have emerged. The proposed study will use previously collected, prospective data to verify and expand on these findings. In addition, we will address an emerging hypothesis regarding the impact of insulin on thyroid cancer risk. Our specific aims are: (1) to evaluate the relationship between papillary thyroid cancer risk and (a) cruciferous vegetables and isothiocyanates, using a newly developed database, and (b) overall and abdominal adiposity; and (2) to evaluate the association between papillary thyroid cancer risk and dietary factors that are (a) positively related to insulin levels (i.e., refined grains and glycemic load) and (b) inversely related to insulin levels (i.e., whole grains and fiber). These analyses will take place in the context of the California Teachers Study (CTS) and include 117,646 women. Over a ten- year follow-up period (through December 31, 2005), it is anticipated that 154 cases of papillary thyroid cancer will be diagnosed within this cohort. Cancer cases are identified through annual linkage with the California Cancer Registry (CCR) and are over 99% complete. Cohort follow-up for vital status and continued California residence is accomplished through contact with participants and linkage with various databases. Usual dietary intake was assessed at baseline using a validated food-frequency questionnaire. Height and weight were self-reported at baseline and waist and hip circumferences self-measured at the first follow-up; these measurements have also been validated against interviewer measurements in a subsample of the cohort. Cox proportional hazards models with age as the time scale and adjusting for birth cohort will be used to calculate relative risks. The results of this research will have important implications for improving our understanding of the etiology of this disease which disproportionately affects young women.

描述（由申请人提供）：在过去 10 年中，女性甲状腺癌的发病率增长速度比女性或男性的任何其他癌症都要快。然而，尽管已经出现了一些与营养相关的有希望的途径，但其原因仍然很大程度上未知。拟议的研究将使用之前收集的前瞻性数据来验证和扩展这些发现。此外，我们将讨论关于胰岛素对甲状腺癌风险影响的新假设。我们的具体目标是：(1) 使用新开发的数据库评估乳头状甲状腺癌风险与 (a) 十字花科蔬菜和异硫氰酸盐以及 (b) 整体和腹部肥胖之间的关系； (2) 评估甲状腺乳头状癌风险与饮食因素之间的关联，这些因素 (a) 与胰岛素水平呈正相关（即精制谷物和血糖负荷），以及 (b) 与胰岛素水平呈负相关（即全谷物和纤维）。这些分析将在加州教师研究 (CTS) 的背景下进行，包括 117,646 名女性。经过十年的随访（截至 2005 年 12 月 31 日），预计该队列中将诊断出 154 例甲状腺乳头状癌病例。癌症病例通过每年与加州癌症登记处 (CCR) 的联系进行识别，完成率超过 99%。通过与参与者的联系和与各种数据库的链接来完成对生命状况和继续在加州居住的队列随访。使用经过验证的食物频率问卷在基线评估通常的饮食摄入量。在基线时自我报告身高和体重，在第一次随访时自我测量腰围和臀围；这些测量值也已根据调查员在队列子样本中的测量值进行了验证。以年龄为时间尺度并根据出生队列进行调整的 Cox 比例风险模型将用于计算相对风险。这项研究的结果将对提高我们对这种疾病的病因学的理解具有重要意义，这种疾病对年轻女性的影响尤为严重。