PHYTOESTROGENS, PHYSICAL ACTIVITY AND ENDOMETRIAL CANCER

植物雌激素、体力活动和子宫内膜癌

• 批准号: 2896040
• 负责人: PAMELA L HORN-ROSS
• 金额: $ 23.12万
• 依托单位: CANCER PREVENTION INSTIT OF CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-08 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2896040
• 关键词: breast neoplasms; cancer risk; carcinogenesis; clinical research; disease /disorder etiology; exercise; female; hormone related neoplasm /cancer; human subject; interview; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; nutrition related tag; obesity; pathogenic diet; phytoestrogens; plant extracts; uterus neoplasms

DESCRIPTION: This population-based epidemiologic study will examine the role that nutritionally-related factors play in the development of endometrial cancer. Special emphasis will be placed on phytoestrogens (i.e., weak estrogens, derived from plant foods, that may have antiestrogenic effects) and physical activity. Little is known about how these factors affect endometrial cancer risk and both offer potential avenues for prevention. Additionally, there are plans to determine whether the effects of obesity, a strong risk factor for endometrial cancer, can be modified by high levels of phytoestrogen consumption. Building on research currently being conducted, there are plans to examine the effects of seven specific phytoestrogenic compounds. The proposed case-control study will be conducted in the San Francisco Bay Area, an ethnically and culturally heterogeneous population, providing substantial variation in dietary intake, including phytoestrogen consumption, and physical activity. White, African American and Latina women, aged 35-79, diagnosed with endometrial cancer during a three-year period, will be identified. These cases will be frequency-matched to controls, based on ethnicity and five-year age group. Controls will be identified from control women, participating in an ongoing, population-based, case-control study of breast cancer, which addresses analogous hypotheses. The questionnaire being used in that study, which was developed specifically to address these areas (including a comprehensive assessment of diet and lifetime occupational and leisure time physical activity), will be used in the proposed study. In-person interviews will be conducted in English or Spanish and anthropometric measurements taken. After initial examination of the data, analyses will be conducted, using unconditional logistic regression, adjusting for age, ethnicity and potential confounders. By combining this research with the ongoing breast cancer study, the proposed study will provide important information on endometrial cancer aetiology and the relationship between breast and endometrial cancer aetiology in terms of these modifiable, nutritionally-related factors.

描述：这项以人群为基础的流行病学研究将检查 营养相关因素在发展中的作用 子宫内膜癌 将特别强调植物雌激素 (i.e.,弱雌激素，来自植物性食物，可能有 抗雌激素作用）和身体活动。 很少有人知道如何 这些因素影响子宫内膜癌的风险， 预防的途径。 此外，还计划确定是否 肥胖是子宫内膜癌的一个重要危险因素， 被大量的植物雌激素所改变。 以研究为基础 目前正在进行的，有计划审查的影响，七个 特定的植物雌激素化合物。 拟议的病例对照研究将 在旧金山弗朗西斯科湾区进行，在种族和文化上， 不同的人群，饮食摄入量有很大的差异， 包括植物雌激素的消耗和体力活动。 白色，非洲人 美国和拉丁美洲妇女，年龄35-79岁，诊断为子宫内膜癌 在三年内，将确定。 这些个案会 根据种族和5岁年龄组，与对照组频率匹配。 对照组将从对照组妇女中确定， 一项基于人群的乳腺癌病例对照研究， 类似的假设。 这项研究中使用的问卷调查， 专门针对这些领域制定的（包括全面的 饮食和终身职业和休闲时间的评估 ），将用于拟议的研究。 面试将在 用英语或西班牙语进行，并进行人体测量。 在对数据进行初步检查后，将使用 非条件logistic回归，调整年龄、种族和 潜在的混淆因素。 通过将这项研究与正在进行的乳腺癌 癌症研究，拟议的研究将提供重要信息， 子宫内膜癌病因及与乳腺癌的关系 子宫内膜癌病因学在这些可变的， 与营养有关的因素。