ORAL CONTRACEPTIVES AND INFLAMMATORY BOWEL DISEASE RISK

这项研究的主要目标是(1)确定当前 而过去口服避孕药的使用会改变女性患上 发展为溃疡性结肠炎(2)以确定是否发生改变 口服避孕药的风险因持续时间不同而不同 使用的时间，或雌激素/孕激素的含量 使用的制剂(S)；以及(3)确定是否有任何变化 使用口服避孕药的风险被混淆或修改为 其他暴露、疾病或个人特征。 为了达到这些目标，一项以人群为基础的病例对照研究 将在预付费健康计划的成员中进行 为华盛顿州居民服务(团体健康合作社)。 病例将通过审查医疗记录和 出院总结诊断书的计算机档案。 药房的计算机化数据将为所有符合以下条件的人员审查 收到了柳氮磺胺吡啶的处方，这是一种主要的药物 用于治疗溃疡性结肠炎。正在进行的监视 对于溃疡性结肠炎的病例，将由 团体健康合作(GHC)胃肠病专家一段时间 四年了。每个病例将有四名女性年龄匹配的对照 从GHC注册文件中随机选择。 受试者将就目前和过去的使用情况进行面谈。 关于口服避孕药和其他相关暴露和 特征，如生育史、社会经济状况 状况、使用口服避孕药的适应症和吸烟 历史。之前经过验证的面试工具 将采用口服避孕药使用的测量方法。 配对分析和条件Logistic分析的传统方法 将使用回归来估计溃疡性疾病的优势比 口服避孕药使用者结肠炎的调整 潜在的混杂因素。

The main goals of this study are (1) to determine whether current and past use of oral contraceptives alter a woman's risk of developing ulcerative colitis (2) to determine whether alteration in risk due to oral contraceptive use varies according to durations of use, timing of use, or the estrogen/progestin content of the preparation(s) used; and (3) to determine whether any change in risk due to oral contraceptive use is confounded or modified by other exposures, illnessess, or personal characteristics. To accomplish these aims a population based case-control study will be conducted among members of a pre-paid health plan serving residents of Washington State (Group Health Cooperative). Cases will be identified by review of medical records and computer files of hospital discharge summary diagnoses. Pharmacy computerized data will be reviewed for all persons who received a prescription for sulfasalazine, a medication primarily used for the treatment of ulcerative colitis. Ongoing surveillance for incident cases of ulcerative colitis will be performed by the Group Health Cooperative (GHC) gastroenterologists for a period of four years. Four female-age matched controls per case will be randomly selected from the GHC enrollment file. Subjects will be interviewed in person about current and past use of oral contraceptives and about other relevant exposures and characteristics, such as childbearing history, socioeconomic status, indication for use of oral contraceptives, and smoking history. A previously validated interview instrument for measurement of oral contraceptive use will be employed. Traditional methods for matched analysis and conditional logistic regression will be used to estimate the odds ratio for ulcerative colitis among oral contraceptive users while adjusting for potential confounding factors.