ORAL CONTRACEPTIVES AND INFLAMMATORY BOWEL DISEASE RISK

口服避孕药和炎症性肠病风险

• 批准号: 3463253
• 负责人: EDWARD J BOYKO
• 金额: $ 9.65万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3463253
• 关键词: alcoholic beverage consumption; disease /disorder proneness /risk; epidemiology; estrogens; female antifertility drug; gastrointestinal disorder chemotherapy; interview; patient /disease registry; progestins; socioeconomics; sulfanilamides; tobacco abuse; ulcerative colitis

The main goals of this study are (1) to determine whether current and past use of oral contraceptives alter a woman's risk of developing ulcerative colitis (2) to determine whether alteration in risk due to oral contraceptive use varies according to durations of use, timing of use, or the estrogen/progestin content of the preparation(s) used; and (3) to determine whether any change in risk due to oral contraceptive use is confounded or modified by other exposures, illnessess, or personal characteristics. To accomplish these aims a population based case-control study will be conducted among members of a pre-paid health plan serving residents of Washington State (Group Health Cooperative). Cases will be identified by review of medical records and computer files of hospital discharge summary diagnoses. Pharmacy computerized data will be reviewed for all persons who received a prescription for sulfasalazine, a medication primarily used for the treatment of ulcerative colitis. Ongoing surveillance for incident cases of ulcerative colitis will be performed by the Group Health Cooperative (GHC) gastroenterologists for a period of four years. Four female-age matched controls per case will be randomly selected from the GHC enrollment file. Subjects will be interviewed in person about current and past use of oral contraceptives and about other relevant exposures and characteristics, such as childbearing history, socioeconomic status, indication for use of oral contraceptives, and smoking history. A previously validated interview instrument for measurement of oral contraceptive use will be employed. Traditional methods for matched analysis and conditional logistic regression will be used to estimate the odds ratio for ulcerative colitis among oral contraceptive users while adjusting for potential confounding factors.

本研究的主要目标是（1）确定当前 过去使用口服避孕药会改变女性的风险 发展为溃疡性结肠炎 (2) 以确定是否发生改变 口服避孕药使用的风险因持续时间而异 使用方法、使用时间或雌激素/孕激素含量 使用的制剂； (3) 确定是否有任何变化 由于口服避孕药的使用而产生的风险被混淆或改变了 其他暴露、疾病或个人特征。 为了实现这些目标，进行了基于人群的病例对照研究 将在预付费健康计划的成员中进行 为华盛顿州的居民提供服务（团体健康合作社）。 将通过审查医疗记录和 出院诊断摘要的计算机文件。 所有人员的药房计算机化数据都将受到审查 收到了柳氮磺吡啶的处方，主要是一种药物 用于治疗溃疡性结肠炎。 持续监控 对于溃疡性结肠炎的突发病例，将由 团体健康合作社 (GHC) 胃肠病学家一段时间 四年。 每个病例有四个年龄匹配的女性对照 从 GHC 注册文件中随机选择。 受试者将接受有关当前和过去使用情况的面对面采访 口服避孕药和其他相关暴露以及 特征，例如生育史、社会经济状况 状况、使用口服避孕药的指征和吸烟 历史。 之前经过验证的访谈工具 将采用口服避孕药使用情况的测量。 匹配分析和条件逻辑的传统方法 回归将用于估计溃疡性结肠炎的优势比 口服避孕药使用者的结肠炎，同时调整 潜在的混杂因素。