Core C: Human Studies Core

核心 C：人类研究核心

• 批准号: 8441162
• 负责人: EDWARD J BOYKO
• 金额: $ 9.88万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8441162
• 关键词: Adipose tissue; Beta Cell; Blood specimen; Cell physiology; Cells; Clinical; Clinical Research; Communities; Complement; Computerized Medical Record; Diabetes Mellitus; Disease; Epidemiologic Studies; Epidemiology; Fostering; Funding; Glucose; Goals; Health; Health Sciences; Human; Hyperglycemia; Information Centers; Institutes; Intravenous; Kinetics; Metabolic; Mission; Nature; OGTT; Obesity; Oral; Peer Review Grants; Phenotype; Productivity; Publications; Research; Research Design; Research Institute; Research Methodology; Research Personnel; Research Technics; Resources; Services; Site; Tracer; Training; Translational Research; Universities; Washington; data modeling; design; glucose disposal; insulin sensitivity; interest; intravenous glucose tolerance test; mathematical model; multidisciplinary; nutrition; research study; response; translational health science

The Human Studies Core has been a component of the Diabetes Research Center since 1974, reflecting the historically strong focus ofthe University of Washington on clinical research. The Core's mission is to provide affiliate investigators with multiple resources to support the conduct of human research. To achieve this mission, the Human Studies Core has the following goals: (1) Perform metabolic phenotyping studies consisting of clamps with isotopic tracers to determine site-specific rates of glucose kinetics, hyperglycemic clamps to assess beta-cell function, and oral and intravenous glucose tolerance tests; (2) Obtain blood samples and adipose tissue from identified subjects; (3) Model data from mixed meal, intravenous and oral glucose tolerance tests to estimate parameters of interest pertaining to beta-cell function, insulin sensitivity and glucose disposal; (4) Utilize existing state-of-the-art electronic medical record and other clinical resources to identify potential subjects for clinical and epidemiological research in diabetes, obesity and related disorders; and (5) Assist with and train in the design and conduct of clinical research including statistical analysis. Many of the services offered by the Human Studies Core are unique in the local research community and, if not for the existence of the Diabetes Research Center, would be unavailable to investigators. By leveraging with other groups, the Center offers services to its affiliates that complement those available through the UW Nutrition Obesity Research Center, the Institute of Translational Health Sciences (the CTSA), the Group Health Research Institute, the VA Epidemiologic Research and Information Center, and the Washington Phenotyped Biospecimen Resource. In this manner, the Human Studies Core supports the conduct of human research in diabetes, obesity and related conditions.

自 1974 年以来，人类研究核心一直是糖尿病研究中心的组成部分，反映了 华盛顿大学历来非常注重临床研究。核心的使命是 为附属研究人员提供多种资源来支持人类研究的进行。达到 针对这一使命，人类研究核心有以下目标：（1）进行代谢表型研究 由带有同位素示踪剂的夹子组成，用于确定葡萄糖动力学、高血糖的位点特异性速率 用于评估 β 细胞功能的钳夹，以及口服和静脉注射葡萄糖耐量测试； (2) 取血 来自已确定受试者的样本和脂肪组织； (3) 混合膳食、静脉注射和口服的模型数据 葡萄糖耐量测试可估计与 β 细胞功能、胰岛素敏感性相关的感兴趣参数 和葡萄糖处置； （4）利用现有最先进的电子病历和其他临床数据 确定糖尿病、肥胖症和流行病学临床和流行病学研究潜在受试者的资源 相关疾病； (5) 协助并培训临床研究的设计和实施，包括 统计分析。人类研究核心提供的许多服务在当地研究中是独一无二的 社区，如果没有糖尿病研究中心的存在，将无法 调查人员。通过与其他团体的合作，该中心为其附属机构提供补充服务 这些可通过华盛顿大学营养肥胖研究中心、转化健康研究所获得 科学 (CTSA)、团体健康研究所、VA 流行病学研究和信息 中心和华盛顿表型生物样本资源。通过这种方式，人类研究核心 支持对糖尿病、肥胖症及相关疾病进行人类研究。