Core C: Human Studies Core

自1974年以来，人类研究核心一直是糖尿病研究中心的一个组成部分，反映了 华盛顿大学在临床研究上的历史性的重点。内核的使命是 为附属研究者提供多种资源，以支持人类研究的开展。实现 在这一使命中，人类研究中心有以下目标：（1）进行代谢表型研究 包括具有同位素示踪剂的夹子，以确定葡萄糖动力学、高血糖 钳夹以评估β细胞功能，以及口服和静脉内葡萄糖耐量试验;（2）获取血液 （3）来自混合餐、静脉内和口服的模型数据 葡萄糖耐量试验，以估计与β细胞功能、胰岛素敏感性 （4）利用现有最先进的电子病历和其他临床 资源，以确定潜在的主题，为临床和流行病学研究的糖尿病，肥胖和 相关疾病;以及（5）协助并培训临床研究的设计和实施，包括 统计分析人文学科中心提供的许多服务在本地研究中是独一无二的 社区，如果没有糖尿病研究中心的存在，将无法获得 investigators.通过与其他团体合作，该中心为其附属机构提供服务， 那些可通过UW营养肥胖研究中心，转化健康研究所 科学（CTSA），集团健康研究所，VA流行病学研究和信息 中心，和华盛顿表型生物标本资源。在这种情况下，人类研究的核心 支持糖尿病、肥胖症和相关疾病的人类研究。

The Human Studies Core has been a component of the Diabetes Research Center since 1974, reflecting the historically strong focus ofthe University of Washington on clinical research. The Core's mission is to provide affiliate investigators with multiple resources to support the conduct of human research. To achieve this mission, the Human Studies Core has the following goals: (1) Perform metabolic phenotyping studies consisting of clamps with isotopic tracers to determine site-specific rates of glucose kinetics, hyperglycemic clamps to assess beta-cell function, and oral and intravenous glucose tolerance tests; (2) Obtain blood samples and adipose tissue from identified subjects; (3) Model data from mixed meal, intravenous and oral glucose tolerance tests to estimate parameters of interest pertaining to beta-cell function, insulin sensitivity and glucose disposal; (4) Utilize existing state-of-the-art electronic medical record and other clinical resources to identify potential subjects for clinical and epidemiological research in diabetes, obesity and related disorders; and (5) Assist with and train in the design and conduct of clinical research including statistical analysis. Many of the services offered by the Human Studies Core are unique in the local research community and, if not for the existence of the Diabetes Research Center, would be unavailable to investigators. By leveraging with other groups, the Center offers services to its affiliates that complement those available through the UW Nutrition Obesity Research Center, the Institute of Translational Health Sciences (the CTSA), the Group Health Research Institute, the VA Epidemiologic Research and Information Center, and the Washington Phenotyped Biospecimen Resource. In this manner, the Human Studies Core supports the conduct of human research in diabetes, obesity and related conditions.