ORAL CONTRACEPTIVES AND INFLAMMATORY BOWEL DISEASE RISK

本研究的主要目的是（1）确定当前是否 和过去使用口服避孕药改变了妇女的风险， 发展溃疡性结肠炎（2），以确定是否改变 由于口服避孕药使用的风险因持续时间而异 使用的时间，或雌激素/孕激素的含量 （3）确定是否有任何变化， 使用口服避孕药的风险被以下因素混淆或改变： 其他暴露、疾病或个人特征。 为了实现这些目标，一项基于人群的病例对照研究 将在预付健康计划的成员中进行 服务于华盛顿州居民（团体健康合作社）。 病例将通过审查病历来确定， 出院总结诊断的计算机文件。 将审查所有符合以下条件的人员的药房计算机化数据： 我收到了柳氮磺胺吡啶的处方， 用于治疗溃疡性结肠炎。 持续监测 对于溃疡性结肠炎的偶发病例，将由 团体健康合作社（GHC）胃肠病学家一段时间 四年了 每例病例将有4名女性-年龄匹配的对照， 从GHC注册文件中随机选择。 受试者将亲自接受采访，了解当前和过去的使用情况 关于口服避孕药和其他相关接触的资料， 特征，如生育史，社会经济 口服避孕药的状况、使用适应症和吸烟 历史 一个先前验证过的访谈工具， 将对口服避孕药的使用进行测量。 传统的配对分析方法和条件Logistic 回归将用于估计溃疡性结肠炎的比值比。 口服避孕药使用者中的结肠炎， 潜在的混杂因素。

The main goals of this study are (1) to determine whether current and past use of oral contraceptives alter a woman's risk of developing ulcerative colitis (2) to determine whether alteration in risk due to oral contraceptive use varies according to durations of use, timing of use, or the estrogen/progestin content of the preparation(s) used; and (3) to determine whether any change in risk due to oral contraceptive use is confounded or modified by other exposures, illnessess, or personal characteristics. To accomplish these aims a population based case-control study will be conducted among members of a pre-paid health plan serving residents of Washington State (Group Health Cooperative). Cases will be identified by review of medical records and computer files of hospital discharge summary diagnoses. Pharmacy computerized data will be reviewed for all persons who received a prescription for sulfasalazine, a medication primarily used for the treatment of ulcerative colitis. Ongoing surveillance for incident cases of ulcerative colitis will be performed by the Group Health Cooperative (GHC) gastroenterologists for a period of four years. Four female-age matched controls per case will be randomly selected from the GHC enrollment file. Subjects will be interviewed in person about current and past use of oral contraceptives and about other relevant exposures and characteristics, such as childbearing history, socioeconomic status, indication for use of oral contraceptives, and smoking history. A previously validated interview instrument for measurement of oral contraceptive use will be employed. Traditional methods for matched analysis and conditional logistic regression will be used to estimate the odds ratio for ulcerative colitis among oral contraceptive users while adjusting for potential confounding factors.