Core C: Human Studies Core

人类研究核心自1974年以来一直是糖尿病研究中心的一个组成部分，反映了 华盛顿大学历来专注于临床研究。核心的使命是 为附属调查人员提供多种资源，以支持人类研究的开展。要实现 这项任务，人类研究核心有以下目标：(1)进行代谢表型研究 由带有同位素示踪剂的夹子组成，用于确定特定部位的葡萄糖动力学、高血糖 用于评估β细胞功能的钳夹，以及口服和静脉葡萄糖耐量试验；(2)采集血液 来自确定受试者的样本和脂肪组织；(3)混合膳食、静脉注射和口服的模型数据 糖耐量试验评估与β细胞功能、胰岛素敏感性有关的感兴趣的参数 和葡萄糖处理；(4)利用现有最先进的电子病历和其他临床 确定糖尿病、肥胖症和糖尿病的临床和流行病学研究的潜在对象的资源 相关障碍；以及(5)协助和培训临床研究的设计和实施，包括 统计分析。人文科学中心提供的许多服务在当地研究中是独一无二的 社区，如果没有糖尿病研究中心的存在，就不会有 调查人员。通过与其他团体的合作，该中心向其附属机构提供服务，以补充 这些可以通过华盛顿大学营养肥胖研究中心，翻译健康研究所获得 科学(CTSA)、群体健康研究所、退伍军人事务部流行病学研究和信息 中心，和华盛顿表型生物谱系资源。通过这种方式，人文科学的核心 支持开展糖尿病、肥胖症及相关疾病的人体研究。

The Human Studies Core has been a component of the Diabetes Research Center since 1974, reflecting the historically strong focus ofthe University of Washington on clinical research. The Core's mission is to provide affiliate investigators with multiple resources to support the conduct of human research. To achieve this mission, the Human Studies Core has the following goals: (1) Perform metabolic phenotyping studies consisting of clamps with isotopic tracers to determine site-specific rates of glucose kinetics, hyperglycemic clamps to assess beta-cell function, and oral and intravenous glucose tolerance tests; (2) Obtain blood samples and adipose tissue from identified subjects; (3) Model data from mixed meal, intravenous and oral glucose tolerance tests to estimate parameters of interest pertaining to beta-cell function, insulin sensitivity and glucose disposal; (4) Utilize existing state-of-the-art electronic medical record and other clinical resources to identify potential subjects for clinical and epidemiological research in diabetes, obesity and related disorders; and (5) Assist with and train in the design and conduct of clinical research including statistical analysis. Many of the services offered by the Human Studies Core are unique in the local research community and, if not for the existence of the Diabetes Research Center, would be unavailable to investigators. By leveraging with other groups, the Center offers services to its affiliates that complement those available through the UW Nutrition Obesity Research Center, the Institute of Translational Health Sciences (the CTSA), the Group Health Research Institute, the VA Epidemiologic Research and Information Center, and the Washington Phenotyped Biospecimen Resource. In this manner, the Human Studies Core supports the conduct of human research in diabetes, obesity and related conditions.