Multi-modal retinal biomarkers for vascular dementia: developing enabling image analysis tools

血管性痴呆的多模态视网膜生物标志物：开发可行的图像分析工具

• 批准号: EP/M005976/1
• 负责人: Emanuele Trucco
• 金额: $ 117.61万
• 依托单位: University of Dundee
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM005976%2F1
• 关键词: Multi; modal; retinal; biomarkers; vascular

Dementia is a devastating disease. It has catastrophic implications for affected individuals, their family, wider society, and heavy, increasing costs for the NHS. Detecting subjects at increased risk of developing dementia in the future, and detecting adverse risk at the earliest stages of dementia, may present opportunities to preserve brain function and delay disease progression. There is increasing recognition that degeneration of brain blood vessels plays a role in the development of dementia. It is therefore important to identify patients likely to present such degeneration as early as possible, as they may require special treatment and the disease progress can be delayed.There is also strong clinical evidence that the brain blood vessels are related to those in the retina, the part of the eye responsible for the first stage of human vision. The retina is checked routinely by high-street opticians, hence retinal images (fundus photography and optical coherence tomography, now both available on a single device) could provide an inexpensive, non-invasive procedure capable of capturing early signs of dementia or those at high risk of developing dementia. It would exploit widely available existing examinations and be deployable immediately. Hence the potential impact of a retinal test for dementia signs would be huge. The central question is whether the retina can provide (a) reliable biomarkers (signs) for future risk of dementia, and (b) sensitive biomarkers of disease progression of either cognitive decline or brain vessels degeneration. Our purpose is to develop enabling technologies based on image analysis to identify such biomarkers, using easily accessible retinal features (supporting an uninvasive, inexpensive, easily accessible and high-specificity test), and joint brain-retina features (a larger-scope investigation motivated by the affinity of small vessels of brain and retina). We shall validate the technologies in a pilot study in collaboration with the specialist units at the University Hospitals of Dundee and Edinburgh, including ophthalmology, brain imaging, and cognitive ageing and cognitive epidemiology. Our research is supported by the Alzheimer's Society.

痴呆症是一种毁灭性的疾病。它对受影响的个人、他们的家庭、更广泛的社会产生灾难性影响，并给国民医疗服务体系带来沉重且不断增加的成本。检测未来患痴呆症风险增加的受试者，并在痴呆症的早期阶段检测不良风险，可能为保护大脑功能和延缓疾病进展提供机会。人们越来越认识到脑血管退化在痴呆症的发展中发挥着重要作用。因此，尽早识别可能出现这种退化的患者非常重要，因为他们可能需要特殊治疗，并且可以延迟疾病进展。还有强有力的临床证据表明，脑血管与视网膜中的血管有关，视网膜是眼睛中负责人类视觉第一阶段的部分。大街上的配镜师会定期检查视网膜，因此视网膜图像（眼底摄影和光学相干断层扫描，现在都可以在单个设备上使用）可以提供一种廉价、非侵入性的程序，能够捕获痴呆症的早期迹象或患痴呆症的高风险人群。它将利用广泛可用的现有检查并可立即部署。因此，视网膜测试对痴呆症迹象的潜在影响将是巨大的。核心问题是视网膜是否可以提供（a）未来痴呆风险的可靠生物标志物（迹象），以及（b）认知能力下降或脑血管退化疾病进展的敏感生物标志物。我们的目的是开发基于图像分析的使能技术，以识别此类生物标志物，使用易于访问的视网膜特征（支持无创、廉价、易于访问和高特异性的测试）和联合脑-视网膜特征（由大脑和视网膜小血管的亲和力推动的更大范围的研究）。我们将与邓迪大学医院和爱丁堡大学医院的专家单位合作，在试点研究中验证这些技术，包括眼科、脑成像、认知衰老和认知流行病学。我们的研究得到了阿尔茨海默氏症协会的支持。

项目成果

Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects.

• DOI: 10.1016/j.cccb.2020.100002
• 发表时间: 2020
• 期刊: Cerebral circulation - cognition and behavior
• 作者: Ballerini L;McGrory S;Valdés Hernández MDC;Lovreglio R;Pellegrini E;MacGillivray T;Muñoz Maniega S;Henderson R;Taylor A;Bastin ME;Doubal F;Trucco E;Deary IJ;Wardlaw J
• 通讯作者: Wardlaw J

Stroke in the Older Person

老年人中风

• 发表时间: 2020
• 作者: Blair G

Developing a well-received pre-matriculation program: the evolution of MedFIT.

制定广受好评的预科课程：MedFIT 的演变。

• DOI: 10.1007/978-3-319-11970-0_12
• 发表时间: 2022
• 期刊: Discover education
• 作者: Allen A