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Multi-modal AO-LSO Phase Gradient Imaging of the Inner Retina

内视网膜多模态 AO-LSO 相位梯度成像

基本信息

批准号：
8524620
负责人：
R DANIEL FERGUSON
金额：
$ 20.32万
依托单位：
PHYSICAL SCIENCES, INC
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8524620
关键词：
Address Algorithms Alzheimer&apos s Disease Apoptosis Area Back Biological Process Blood Vessels Boston Cellular Structures Clinic Clinical Clinical Investigator Clinical Research Collaborations Coupling Detection Development Diabetic Retinopathy Diagnosis Discrimination Disease Disease Progression Engineering Evaluation Eye Eye diseases Feedback Floods Flying body movement Fundus Glaucoma Goals Government Human Human Volunteers Image Lasers Lateral Lead Left Life Light Lighting Masks Measures Methods Microscopy Monitor Nerve Degeneration Neurons Ophthalmoscopes Ophthalmoscopy Optics Pathology Patients Pattern Pediatric Hospitals Persons Pharmacotherapy Phase Phase-Contrast Microscopy Photophobia Photoreceptors Physiological Positioning Attribute Process Proxy Pupil Reading Relative (related person)Research Research Personnel Resolution Retina Retinal Retinal Cone Retinal Degeneration Retinal Ganglion Cells Retinopathy of Prematurity Scanning Scheme Scientist Side Source Speed Spottings Staging System Technology Testing Thick Time Tissues Vision Vision research adaptive optics base cellular imaging clinical application design drug discovery flexibility imaging modality improved in vivo in vivo imaging insight instrument instrumentation neuronal cell body novel novel strategies optical imaging physical science programs prototype public health relevance receptor relating to nervous system retinal nerve fiber layer retinal neuron sensor tool transmission process volunteer

项目摘要

Project Summary/Abstract Powerful new Adapative Optics imaging technoIogies which sense ocular aberrations with a wave- front sensor and corrects them with a deformable mirror wave-front compensator, like Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO) and AO-OCT, provide detailed anatomical, physiological and functional information at the cellular level in the human eye. Physical Sciences Inc. (PSI) has recently demonstrated a new approach, called adaptive optics line scanning ophthalmoscopy (AO-LSO). The clinical AO-LSO retinal imager, invented and developed at PSI, greatly simplifies AO optical design, eliminates high-speed scanning components, and reduces the clinical footprint compared to research AOSLOs, while preserving many of the advantages of (line-)confocal imaging for resolving retinal layers. Although the AOSLO and AO-LSO provide the ability to routinely image and count cone photoreceptors, at present, there are no direct approaches for in vivo imaging of retinal ganglion cells in the human eye, or counting cell bodies in the inner retina. Our goal in Phase I is to demonstrate an advanced new design of the AO-LSO imager, (including an AO-OCT channel), with a new, high-sensitivity camera technology and line-illumination methods for phase gradient imaging of the inner retina. The envisioned platform will be engineered as a compact clinical system for flexible cellular imaging applications in vivo. An AO-LSO prototype instrument will be modified with new line-camera technology in Phase I, and used to investigate new imaging modalities. If successful, this approach and associated imaging algorithms will be improved in Phase II and used to monitor disease progression/regression and characterize inner retinal remodeling in patients at Children's Hospital Boston. A clinical investigator will provide feedback in Phase I and will lead a Phase II clinical study to evaluate the new capabilities of the phase gradient imaging approach. Phase III commercial development will provide clinicians with enhanced adaptive optics imaging capabilities not available in current retinal imagers.

项目总结/文摘