Quantification of vascular and neuronal pathology in dementia using PET and MRI

使用 PET 和 MRI 对痴呆症的血管和神经病理学进行量化

• 批准号: EP/M005909/1
• 负责人: Geoff Parker
• 金额: $ 140.16万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM005909%2F1
• 关键词: Quantification; vascular; neuronal; pathology; dementia

The increasing occurrence of dementia within our ageing population is one of the pressing challenges facing society. Successful management of patients with dementia is significantly aided by early and accurate diagnosis. Imaging methods such as magnetic resonance imaging (MRI) and positron emission tomography (PET) are already used in the diagnostic process; we believe that there is substantial scope for both methods to be improved to provide more precise and sensitive diagnostic information, and to do so in a way that is easily tolerated by patients. If we are correct in this belief, then the methods we develop within this project will not only help in early diagnosis, but may also help in the discovery of new therapies and in the longer term with helping doctors select the best therapeutic strategies for patients with different forms of dementia.Imaging methods such as MRI and PET can tell us a lot more about brains than simply providing a picture of brain shape and size. We will focus on improving MRI and PET to be sensitive to two important microscopic aspects of dementia. Firstly, we will develop and validate new methods for measuring the loss of brain cells due to the condition; this loss is the cause of many of the symptoms of dementia, such as memory problems, and we hope to be able to detect these changes earlier than has previously been possible. Secondly we will develop and validate new methods for measuring changes in blood delivery to the brain and how this can affect oxygen delivery. These changes are thought to be part of one of the important processes involved in causing cell death and tissue loss, and are likely to be particularly relevant to vascular dementia.We will also spend considerable time checking that the measurements we develop are both accurate and practical for application in dementia patients in the future. We will optimise the way in which the scanning processes take place so that the time required for patients to lie in the scanner(s) is minimised. This will be important for future adoption of these methods in the clinical environment.

老年痴呆症在老龄人口中的发病率不断上升，是社会面临的紧迫挑战之一。痴呆症患者的成功管理是由早期和准确的诊断显着帮助。成像方法，如磁共振成像（MRI）和正电子发射断层扫描（PET）已经在诊断过程中使用;我们认为，这两种方法都有很大的改进空间，以提供更精确和灵敏的诊断信息，并以患者容易耐受的方式进行。如果我们的信念是正确的，那么我们在这个项目中开发的方法将不仅有助于早期诊断，而且还可能有助于发现新的治疗方法，并在长期内帮助医生为不同形式的痴呆症患者选择最佳的治疗策略。成像方法，如MRI和PET可以告诉我们更多关于大脑的信息，而不仅仅是提供大脑形状和大小的图片。我们将专注于改进MRI和PET，使其对痴呆症的两个重要微观方面敏感。首先，我们将开发和验证新的方法来测量脑细胞的损失，由于条件;这种损失是痴呆症的许多症状的原因，如记忆问题，我们希望能够比以前更早地检测到这些变化。其次，我们将开发和验证新的方法来测量血液输送到大脑的变化，以及这如何影响氧气输送。这些变化被认为是导致细胞死亡和组织损失的重要过程之一的一部分，并且可能与血管性痴呆特别相关。我们还将花费相当多的时间来检查我们开发的测量方法是否准确和实用，以便将来应用于痴呆患者。我们将优化扫描过程的方式，以便最大限度地减少患者躺在扫描仪中所需的时间。这对于将来在临床环境中采用这些方法将是重要的。

项目成果

Blood-Brain Barrier Leakage Is Increased in Parkinson's Disease.

• DOI: 10.3389/fphys.2020.593026
• 发表时间: 2020
• 期刊: Frontiers in physiology
• 影响因子: 4
• 作者: Al-Bachari S;Naish JH;Parker GJM;Emsley HCA;Parkes LM
• 通讯作者: Parkes LM

Dynamic Contrast Enhanced MRI reveals blood-brain barrier disruption in Parkinson's disease

动态对比增强 MRI 揭示帕金森病的血脑屏障破坏

• 发表时间: 2019
• 作者: Al-Bachari S

Accuracy and robustness of image-derived input functions (IDIF) for preclinical PET imaging assessed using a dynamic 3D printed phantom

使用动态 3D 打印模型评估临床前 PET 成像的图像衍生输入函数 (IDIF) 的准确性和稳健性

• 发表时间: 2017
• 作者: Asselin MC

Generation and validation of image-derived input functions from rodents using a dynamic 3D printed phantom

使用动态 3D 打印模型生成和验证啮齿动物的图像衍生输入函数

• 发表时间: 2016
• 作者: Asselin MC

Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia.

• DOI: 10.1002/mrm.25197
• 发表时间: 2015-01
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Alsop, David C.;Detre, John A.;Golay, Xavier;Guenther, Matthias;Hendrikse, Jeroen;Hernandez-Garcia, Luis;Lu, Hanzhang;MacIntosh, Bradley J.;Parkes, Laura M.;Smits, Marion;van Osch, Matthias J. P.;Wang, Danny J. J.;Wong, Eric C.;Zaharchuk, Greg
• 通讯作者: Zaharchuk, Greg