Biocatalysis & Biotransformation: A 5th Theme for the National Catalysis Hub

生物催化

• 批准号: EP/M013219/1
• 负责人: Nicholas Turner
• 金额: $ 395.51万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM013219%2F1
• 关键词: Biocatalysis; Biotransformation; 5th; Theme; National

The proposed research looks to establish biocatalysis & biotransformation research at the UK Catalysis Hub. A catalyst is something added in very small amounts to a reaction that will make it faster, and they play a very important role in modern chemistry and biology. Up to 90% of chemically produced materials have used a catalyst in their production - the enzymes in washing powder are a type of biological catalyst that helps break down organic stains on clothes, for example. The catalytic converter in a car contains precious metal catalysts that convert harmful nitrogen monoxide fumes into harmless nitrogen gas. Catalysis in general is integral to the discovery and manufacture of new materials that structure our society - e.g. medicines, agrochemicals, polymers, flavours and fragrances.Catalysts can dramatically accelerate chemical reactions, to the extent where some impossibly slow processes become highly efficient when performed under catalytic conditions. The challenge is matching up the right catalyst with the right chemical reaction. Our research will concentrate on biological catalysis, looking at ways to integrate enzyme and whole cell biocatalysis into new manufacturing processes. It is possible, for example, to integrate metals and biocatalysts into single chemical reactions, such that the synthesis of new molecules would be dramatically accelerated. For this to be possible we need fundamental advances in our understanding of how enzymes work and how metal catalysts can be made to function under mild conditions. The Catalysis Hub offers a unique focal point to realise this research goal, which will drive the development of each arm of catalysis in new and unexpected ways. It brings scientists together from UK universities (and beyond) and industry to tackle major problems in catalysis. The networking of scientists from different disciplines and sectors will permit a cross-disciplinary approach to catalysis that will be essential if we are to drive biocatalysis research forward in its widest context.

拟议的研究旨在在英国催化中心建立生物催化和生物转化研究。催化剂是少量添加的反应，这将使之更快，并且它们在现代化学和生物学中起着非常重要的作用。多达90％的化学生产材料在其生产中使用了催化剂 - 洗衣粉中的酶是一种生物催化剂，有助于分解衣服上的有机污渍。汽车中的催化转化剂含有贵金属催化剂，将有害的一氧化氮烟雾转化为无害的氮气。一般而言，催化是构建我们社会的新材料的发现和制造不可或缺的一部分 - 例如药物，农业化学物质，聚合物，口味和香料。催化剂可以显着加速化学反应，以至于在催化条件下进行某些不可能缓慢的过程会变得高效。挑战是将右催化剂与正确的化学反应相匹配。我们的研究将集中于生物催化，寻找将酶和整个细胞生物催化的方法整合到新的制造过程中。例如，有可能将金属和生物催化剂整合到单个化学反应中，从而使新分子的合成将大大加速。为此，我们需要在理解酶的工作方式以及如何使金属催化剂如何在轻度条件下发挥作用时，需要基本进步。催化枢纽提供了一个独特的焦点来实现这一研究目标，该目标将以新的和意外的方式推动催化的每个臂的发展。它使科学家从英国大学（以及超越）和行业汇集在一起​​，以解决催化中的主要问题。来自不同学科和部门的科学家的网络将允许跨学科的催化方法，如果我们要在其最广泛的背景下推动生物催化研究前进，这将是至关重要的。

项目成果

XPS and STM studies of the oxidation of hydrogen chloride at Cu(100) surfaces

• DOI: 10.1016/j.susc.2015.12.024
• 发表时间: 2016-08
• 期刊: Surface Science
• 影响因子: 1.9
• 作者: H. Altass;A. Carley;P. R. Davies;R. Davies

Teaching Enzyme Catalysis Using Interactive Molecular Dynamics in Virtual Reality

• DOI: 10.1021/acs.jchemed.9b00181
• 发表时间: 2019-11-01
• 期刊: JOURNAL OF CHEMICAL EDUCATION
• 影响因子: 3
• 作者: Bennie, Simon J.;Ranaghan, Kara E.;Glowacki, David R.
• 通讯作者: Glowacki, David R.

P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

• DOI: 10.1021/acscatal.8b00389
• 发表时间: 2018-04-01
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Acevedo-Rocha, Carlos G.;Gamble, Charles G.;Reetz, Manfred T.
• 通讯作者: Reetz, Manfred T.

From Bugs to Bioplastics: Total (+)-Dihydrocarvide Biosynthesis by Engineered Escherichia coli.

• DOI: 10.1002/cbic.201800606
• 发表时间: 2019-03-15
• 期刊: Chembiochem : a European journal of chemical biology
• 作者: Ascue Avalos GA;Toogood HS;Tait S;Messiha HL;Scrutton NS
• 通讯作者: Scrutton NS

Chemo-enzymatic routes towards the synthesis of bio-based monomers and polymers

• DOI: 10.1016/j.mcat.2019.01.036
• 发表时间: 2019-04-01
• 期刊: MOLECULAR CATALYSIS
• 影响因子: 4.6
• 作者: Ahmed, Syed T.;Leferink, Nicole G. H.;Scrutton, Nigel S.
• 通讯作者: Scrutton, Nigel S.