Biocatalysis & Biotransformation: A 5th Theme for the National Catalysis Hub

生物催化

• 批准号: EP/M013219/1
• 负责人: Nicholas Turner
• 金额: $ 395.51万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM013219%2F1
• 关键词: Biocatalysis; Biotransformation; 5th; Theme; National

The proposed research looks to establish biocatalysis & biotransformation research at the UK Catalysis Hub. A catalyst is something added in very small amounts to a reaction that will make it faster, and they play a very important role in modern chemistry and biology. Up to 90% of chemically produced materials have used a catalyst in their production - the enzymes in washing powder are a type of biological catalyst that helps break down organic stains on clothes, for example. The catalytic converter in a car contains precious metal catalysts that convert harmful nitrogen monoxide fumes into harmless nitrogen gas. Catalysis in general is integral to the discovery and manufacture of new materials that structure our society - e.g. medicines, agrochemicals, polymers, flavours and fragrances.Catalysts can dramatically accelerate chemical reactions, to the extent where some impossibly slow processes become highly efficient when performed under catalytic conditions. The challenge is matching up the right catalyst with the right chemical reaction. Our research will concentrate on biological catalysis, looking at ways to integrate enzyme and whole cell biocatalysis into new manufacturing processes. It is possible, for example, to integrate metals and biocatalysts into single chemical reactions, such that the synthesis of new molecules would be dramatically accelerated. For this to be possible we need fundamental advances in our understanding of how enzymes work and how metal catalysts can be made to function under mild conditions. The Catalysis Hub offers a unique focal point to realise this research goal, which will drive the development of each arm of catalysis in new and unexpected ways. It brings scientists together from UK universities (and beyond) and industry to tackle major problems in catalysis. The networking of scientists from different disciplines and sectors will permit a cross-disciplinary approach to catalysis that will be essential if we are to drive biocatalysis research forward in its widest context.

拟议的研究着眼于在英国催化中心建立生物催化和生物转化研究。催化剂是在反应中加入非常少量的东西，可以使反应更快，它们在现代化学和生物学中起着非常重要的作用。高达90%的化学生产材料在生产过程中使用了催化剂——例如，洗衣粉中的酶是一种生物催化剂，可以帮助分解衣服上的有机污渍。汽车上的催化转化器含有贵重金属催化剂，可以将有害的一氧化氮烟雾转化为无害的氮气。总的来说，催化对于发现和制造构成我们社会的新材料是不可或缺的，例如药物、农用化学品、聚合物、香料和香水。催化剂可以极大地加速化学反应，在某种程度上，一些不可能缓慢的过程在催化条件下变得非常高效。挑战在于将正确的催化剂与正确的化学反应相匹配。我们的研究将集中在生物催化上，寻找将酶和全细胞生物催化整合到新的制造工艺中的方法。例如，将金属和生物催化剂整合到单一的化学反应中是可能的，这样新分子的合成就会大大加快。为了使这成为可能，我们需要在理解酶如何工作以及如何使金属催化剂在温和条件下发挥作用方面取得根本性的进展。催化中心为实现这一研究目标提供了一个独特的焦点，这将以新的和意想不到的方式推动催化的每个分支的发展。它将来自英国大学（及其他）和工业界的科学家聚集在一起，解决催化方面的重大问题。来自不同学科和部门的科学家的网络将允许一种跨学科的催化方法，如果我们要推动生物催化研究在其最广泛的背景下向前发展，这将是必不可少的。

项目成果

XPS and STM studies of the oxidation of hydrogen chloride at Cu(100) surfaces

• DOI: 10.1016/j.susc.2015.12.024
• 发表时间: 2016-08
• 期刊: Surface Science
• 影响因子: 1.9
• 作者: H. Altass;A. Carley;P. R. Davies;R. Davies

Teaching Enzyme Catalysis Using Interactive Molecular Dynamics in Virtual Reality

• DOI: 10.1021/acs.jchemed.9b00181
• 发表时间: 2019-11-01
• 期刊: JOURNAL OF CHEMICAL EDUCATION
• 影响因子: 3
• 作者: Bennie, Simon J.;Ranaghan, Kara E.;Glowacki, David R.
• 通讯作者: Glowacki, David R.

P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

• DOI: 10.1021/acscatal.8b00389
• 发表时间: 2018-04-01
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Acevedo-Rocha, Carlos G.;Gamble, Charles G.;Reetz, Manfred T.
• 通讯作者: Reetz, Manfred T.

Chemo-enzymatic routes towards the synthesis of bio-based monomers and polymers

• DOI: 10.1016/j.mcat.2019.01.036
• 发表时间: 2019-04-01
• 期刊: MOLECULAR CATALYSIS
• 影响因子: 4.6
• 作者: Ahmed, Syed T.;Leferink, Nicole G. H.;Scrutton, Nigel S.
• 通讯作者: Scrutton, Nigel S.

From Bugs to Bioplastics: Total (+)-Dihydrocarvide Biosynthesis by Engineered Escherichia coli.

• DOI: 10.1002/cbic.201800606
• 发表时间: 2019-03-15
• 期刊: Chembiochem : a European journal of chemical biology
• 作者: Ascue Avalos GA;Toogood HS;Tait S;Messiha HL;Scrutton NS
• 通讯作者: Scrutton NS