Novel Biocatalysts for Improved Routes to an Active Pharmaceutical Ingredient

用于改进活性药物成分路线的新型生物催化剂

基本信息

  • 批准号:
    BB/N010736/1
  • 负责人:
  • 金额:
    $ 11.94万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2016
  • 资助国家:
    英国
  • 起止时间:
    2016 至 无数据
  • 项目状态:
    已结题

项目摘要

The use of enzymes to catalyse reactions is a well established technique used in modern organic chemistry as the use of biological catalysts can install unique and exquisite stereochemistry and regiochemistry into a synthetic route. This project will explore the development of two enzymes that catalyse important bond forming reactions in the synthesis of an Active Pharmaceutical Ingredient and their suitability for use as industrial biocatalysts.
使用酶催化反应是现代有机化学中一种成熟的技术,因为使用生物催化剂可以将独特而精致的立体化学和区域化学引入合成路线。该项目将探索两种酶的开发,这两种酶在活性药物成分的合成中催化重要的键形成反应,以及它们作为工业生物催化剂的适用性。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Nicholas Turner其他文献

Pilot randomised controlled trial of school‐based humanistic counselling for psychological distress in young people: Outcomes and methodological reflections
青少年心理困扰校本人文咨询随机对照试验:结果与方法学反思
  • DOI:
    10.1080/14733145.2014.905614
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    J. Pybis;M. Cooper;A. Hill;Karen Cromarty;Ruth Levesley;J. Murdoch;Nicholas Turner
  • 通讯作者:
    Nicholas Turner
Mental health support and training to improve secondary school teachers’ well-being: the WISE cluster RCT
心理健康支持和培训以改善中学教师的福祉:WISE 集群随机对照试验
  • DOI:
    10.3310/phr09120
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. Kidger;Rhiannon Evans;S. Bell;H. Fisher;Nicholas Turner;W. Hollingworth;S. Harding;Jillian Powell;R. Brockman;L. Copeland;R. Araya;R. Campbell;T. Ford;D. Gunnell;Richard Morris;S. Murphy
  • 通讯作者:
    S. Murphy
A multi-centre, three-arm, individually randomised, non-inferiority, open trial to compare immediate orally administered, immediate topically administered or delayed orally administered antibiotics for acute otitis media with discharge in children: The Runny Ear Study (REST): study protocol. Trials,
一项多中心、三组、单独随机、非劣效性、开放性试验,比较立即口服、立即局部给药或延迟口服抗生素治疗有分泌物的儿童急性中耳炎:流涕研究(REST):研究
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    K. Curtis;M. Moore;C. Cabral;V. Curcin;J. Horwood;R. Morris;Vibhore Prasad;A. Schilder;Nicholas Turner;S. Wilkes;A. Hay;Jodi Taylor
  • 通讯作者:
    Jodi Taylor
Alpelisib plus fulvestrant in emPIK3CA/em-mutated, hormone receptor-positive advanced breast cancer after a CDK4/6 inhibitor (BYLieve): one cohort of a phase 2, multicentre, open-label, non-comparative study
阿培利司联合氟维司群治疗 emPIK3CA/雌激素受体突变、激素受体阳性晚期乳腺癌(在 CDK4/6 抑制剂治疗后)(BYLieve):一项 2 期、多中心、开放标签、非对照研究的一个队列
  • DOI:
    10.1016/s1470-2045(24)00673-9
  • 发表时间:
    2024-12-01
  • 期刊:
  • 影响因子:
    35.900
  • 作者:
    Hope S Rugo;Florence Lerebours;Eva Ciruelos;Pamela Drullinsky;Manuel Ruiz-Borrego;Patrick Neven;Yeon Hee Park;Aleix Prat;Thomas Bachelot;Dejan Juric;Nicholas Turner;Nickolas Sophos;Juan Pablo Zarate;Christina Arce;Yu-Ming Shen;Stuart Turner;Hemanth Kanakamedala;Wei-Chun Hsu;Stephen Chia
  • 通讯作者:
    Stephen Chia
P124. Avoiding surgery in breast cancer patients with exceptional Response to neo-adjuvant chemotherapy - ASTARTE Trial
  • DOI:
    10.1016/j.ejso.2019.01.144
  • 发表时间:
    2019-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Marios Konstantinos Tasoulis;Gillian Ross;Nicholas Turner;Navita Somaiah;Romney Pope;Steve Allen;Peter Barry;Jennifer Rusby;Ashutosh Nerurkar;Peter Osin;Fiona MacNeill
  • 通讯作者:
    Fiona MacNeill

Nicholas Turner的其他文献

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{{ truncateString('Nicholas Turner', 18)}}的其他基金

New Synthetic Chaperones to Enhance Protein Activity
增强蛋白质活性的新型合成伴侣
  • 批准号:
    EP/V056085/2
  • 财政年份:
    2023
  • 资助金额:
    $ 11.94万
  • 项目类别:
    Fellowship
Directed Molecular Recognition through Next-Generation Hybrid Molecular Imprinting
通过下一代混合分子印迹进行定向分子识别
  • 批准号:
    EP/V046594/2
  • 财政年份:
    2023
  • 资助金额:
    $ 11.94万
  • 项目类别:
    Research Grant
New Synthetic Chaperones to Enhance Protein Activity
增强蛋白质活性的新型合成伴侣
  • 批准号:
    EP/V056085/1
  • 财政年份:
    2022
  • 资助金额:
    $ 11.94万
  • 项目类别:
    Fellowship
Biocatalytic Manufacturing of Nucleic Acid Therapeutics
核酸治疗药物的生物催化制造
  • 批准号:
    MR/W029324/1
  • 财政年份:
    2022
  • 资助金额:
    $ 11.94万
  • 项目类别:
    Research Grant
Production of Niraparib using Imine Reductases
使用亚胺还原酶生产尼拉帕尼
  • 批准号:
    BB/V003410/1
  • 财政年份:
    2021
  • 资助金额:
    $ 11.94万
  • 项目类别:
    Research Grant
Directed Molecular Recognition through Next-Generation Hybrid Molecular Imprinting
通过下一代混合分子印迹进行定向分子识别
  • 批准号:
    EP/V046594/1
  • 财政年份:
    2021
  • 资助金额:
    $ 11.94万
  • 项目类别:
    Research Grant
Exploration of Linking Chemistry in the Design of Aptamer-Molecularly Imprinted Polymer Hybrids (aptaMIPs)
适配体分子印迹聚合物杂化物 (aptaMIPs) 设计中连接化学的探索
  • 批准号:
    EP/S003339/1
  • 财政年份:
    2019
  • 资助金额:
    $ 11.94万
  • 项目类别:
    Research Grant
Centre for Biocatalytic Manufacture of New Modalities (CBNM)
新模式生物催化制造中心(CBNM)
  • 批准号:
    EP/S005226/1
  • 财政年份:
    2018
  • 资助金额:
    $ 11.94万
  • 项目类别:
    Research Grant
Imine Reductases: Biochemistry, Engineering and Application
亚胺还原酶:生物化学、工程与应用
  • 批准号:
    BB/M006611/1
  • 财政年份:
    2015
  • 资助金额:
    $ 11.94万
  • 项目类别:
    Research Grant
Biocatalysis & Biotransformation: A 5th Theme for the National Catalysis Hub
生物催化
  • 批准号:
    EP/M013219/1
  • 财政年份:
    2015
  • 资助金额:
    $ 11.94万
  • 项目类别:
    Research Grant

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用于极端条件下选择性化学氧化的新型生物催化剂
  • 批准号:
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  • 批准号:
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  • 项目类别:
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CAREER: Characterization and Evolution of N-hydroxylase Biocatalysts: Solutions to Catalysis and Remediating Metal Pollution
职业:N-羟化酶生物催化剂的表征和进化:催化和修复金属污染的解决方案
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    2236643
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