Centre for Biocatalytic Manufacture of New Modalities (CBNM)
Centre for Biocatalytic Manufacture of New Modalities (CBNM)
批准号:
EP/S005226/1
负责人:
Nicholas Turner
金额:
$280.16万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2018
资助国家:
英国
项目状态:
未结题
起止时间:
2018 至 --
中文摘要
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英文摘要
In the ever developing world of pharmaceuticals and treatments of diseases new, more challenging drug targets are being identified that require ever more complex drug molecules. These complex molecules or "New Modalities" bridge the gap between the two existing classes of compounds, small molecules (e.g. Aspirin) and biologics (Antibodies), and are typically larger than the existing small molecules but smaller than traditional biologics. These new classes of molecule offer great promise as novel therapies and indeed many of these medicines are aimed at biological targets that cannot be addressed by traditional either small molecule or antibody derived drugs. The complexity of the new modalities currently results in high cost of manufacture which offers an opportunity to develop lower cost routes to produce these compounds. Small molecule manufacturer has benefited from adopting biocatalysis within manufacturing strategies and has demonstrated the potential for use of these catalysts in wider chemical manufacture, such as reduced waste streams, lower energy costs and reduced costs of goods including solvents. Indeed, the project partners have already generated some early proof-of-concept studies, backed up by a wider literature evidence base suggesting that biocatalysis can be used in the synthesis of these new modalities.Through the partnership of the University of Manchester, AstraZeneca and Prozomix we are bringing together a diverse range of experts that will facilitate the development of new manufacturing strategies to produce these new modalities in an efficient and cleaner manner. The use of biocatalysis has the potential to allow access to chemistries and control of manufacture that are otherwise unavailable to the pharmaceutical manufacturing community. Culminating in lower cost manufacturing that translates into greater access to the next generation of drug for a wider community.
期刊论文(10)
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DOI:
10.1038/s43586-021-00044-z
发表时间:
2021-06-24
期刊:
NATURE REVIEWS METHODS PRIMERS
影响因子:
--
作者:
[Bell, Elizabeth L., Finnigan, William, Flitsch, Sabine L.]
通讯作者:
Flitsch, Sabine L.
DOI:
10.1016/j.ijms.2021.116588
发表时间:
2021-03-26
期刊:
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
影响因子:
1.8
作者:
[Black, Rachelle, Barkhanskiy, Alexey, Barran, Perdita E.]
通讯作者:
Barran, Perdita E.
DOI:
10.1021/acscatal.2c05231
发表时间:
2022-12-16
期刊:
ACS CATALYSIS
影响因子:
12.9
作者:
[Barker, Rhys D., Yu, Yuqi, De Maria, Leonardo, Johannissen, Linus O., Scrutton, Nigel S.]
通讯作者:
Scrutton, Nigel S.
DOI:
10.1021/jacs.3c07010
发表时间:
2023-10-11
期刊:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子:
15
作者:
[Casamajo, Arnau Rue, Yu, Yuqi, Schnepel, Christian, Morrill, Charlotte, Barker, Rhys, Levy, Colin W., Finnigan, James, Spelling, Victor, Westerlund, Kristina, Petchey, Mark, Sheppard, Robert J., Lewis, Richard J., Falcioni, Francesco, Hayes, Martin A., Turner, Nicholas J.]
通讯作者:
Turner, Nicholas J.
DOI:
10.1021/acs.chemrev.2c00600
发表时间:
2023-03-22
期刊:
CHEMICAL REVIEWS
影响因子:
62.1
作者:
[Christofi, Emilia, Barran, Perdita]
通讯作者:
Barran, Perdita
共 9 条
New Synthetic Chaperones to Enhance Protein Activity
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批准号:EP/V056085/2
-
项目类别:Fellowship
-
资助金额:$136.79万
-
财政年份:2023
-
负责人:Nicholas Turner
-
依托单位:
Directed Molecular Recognition through Next-Generation Hybrid Molecular Imprinting
-
批准号:EP/V046594/2
-
项目类别:Research Grant
-
资助金额:$17.83万
-
财政年份:2023
-
负责人:Nicholas Turner
-
依托单位:
New Synthetic Chaperones to Enhance Protein Activity
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批准号:EP/V056085/1
-
项目类别:Fellowship
-
资助金额:$165.83万
-
财政年份:2022
-
负责人:Nicholas Turner
-
依托单位:
Biocatalytic Manufacturing of Nucleic Acid Therapeutics
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批准号:MR/W029324/1
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项目类别:Research Grant
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资助金额:$817.8万
-
财政年份:2022
-
负责人:Nicholas Turner
-
依托单位:
Production of Niraparib using Imine Reductases
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批准号:BB/V003410/1
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项目类别:Research Grant
-
资助金额:$24.83万
-
财政年份:2021
-
负责人:Nicholas Turner
-
依托单位:
Directed Molecular Recognition through Next-Generation Hybrid Molecular Imprinting
-
批准号:EP/V046594/1
-
项目类别:Research Grant
-
资助金额:$34.42万
-
财政年份:2021
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负责人:Nicholas Turner
-
依托单位:
Exploration of Linking Chemistry in the Design of Aptamer-Molecularly Imprinted Polymer Hybrids (aptaMIPs)
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批准号:EP/S003339/1
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项目类别:Research Grant
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资助金额:$37.72万
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财政年份:2019
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负责人:Nicholas Turner
-
依托单位:
Novel Biocatalysts for Improved Routes to an Active Pharmaceutical Ingredient
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批准号:BB/N010736/1
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项目类别:Research Grant
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资助金额:$11.94万
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财政年份:2016
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负责人:Nicholas Turner
-
依托单位:
Imine Reductases: Biochemistry, Engineering and Application
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批准号:BB/M006611/1
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项目类别:Research Grant
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资助金额:$39.5万
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财政年份:2015
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负责人:Nicholas Turner
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依托单位:
Biocatalysis & Biotransformation: A 5th Theme for the National Catalysis Hub
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批准号:EP/M013219/1
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项目类别:Research Grant
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资助金额:$395.51万
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财政年份:2015
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负责人:Nicholas Turner
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依托单位:
European Partnering Award: CoEBio3
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批准号:BB/L027003/1
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项目类别:Research Grant
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资助金额:$2.58万
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财政年份:2014
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负责人:Nicholas Turner
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依托单位:
Network in Biocatalyst Discovery, Development and Scale-Up
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批准号:BB/L013649/1
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项目类别:Research Grant
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资助金额:$218.24万
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财政年份:2014
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负责人:Nicholas Turner
-
依托单位:
Generation of Aptamer-Molecularly Imprinted Polymer Hybrid Materials
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批准号:EP/K015095/1
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项目类别:Research Grant
-
资助金额:$12.53万
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财政年份:2013
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负责人:Nicholas Turner
-
依托单位:
Rapid Evolution of Enzymes and Synthetic Micro-organisms for the Development of Industrial Biocatalysts
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批准号:BB/K00199X/1
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项目类别:Research Grant
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资助金额:$459.23万
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财政年份:2012
-
负责人:Nicholas Turner
-
依托单位:
海外基金