NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION

心脏肾上腺素神经支配的无创评估

• 批准号: 3470901
• 负责人: MICHAEL W DAE
• 金额: $ 8.71万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3470901
• 关键词: adenylate cyclase; beta adrenergic receptor; catecholamines; disease /disorder proneness /risk; electrophysiology; fluorescence microscopy; heart imaging /visualization /scanning; heart innervation; myocardial infarction; noninvasive diagnosis; sympathetic nervous system; ventricular fibrillation

The sympathetic nervous system plays an important role in the genesis of serious ventricular arrhythmias, particularly during myocardial ischemia or after myocardial infarction. In animal models of experimental myocardial infarction, the proposed research will seek: 1) to noninvasively map the distribution of myocardial sympathetic nerves and the distribution of viable perfused myocardium using radionuclide scintigraphy and functional images; 2) to compare the scintigraphic patterns to the regional morphology of sympathetic nerves determined by catecholamine fluorescence microscopy, and to the regional catecholamine content, beta receptor density, and adenylcyclase activity, determined biochemically; 3) to determine the effects of alterations in sympathetic innervation on the electrical stability of the myocardium using programmed stimulation techniques. The results of these experiments may provide important new insights into mechanisms of ventricular arrhythmias in ischemic heart disease, and also may improve identification of patients who are at risk for these lethal ventricular arrhythmias.

交感神经系统在神经系统中起着重要的作用。 严重室性心律失常的发生，特别是在 心肌缺血或心肌梗死后。 在动物 实验性心肌梗死模型，建议 研究将寻求：1）非侵入性地绘制 心肌交感神经和存活神经的分布 使用放射性核素造影术灌注心肌， 功能图像; 2）将心电图模式与 交感神经的局部形态学， 儿茶酚胺荧光显微镜，并以区域 儿茶酚胺含量、β受体密度和腺苷酸环化酶 活性，确定生物化学; 3）确定的影响， 交感神经支配的改变对电稳定性的影响 的心肌组织。 这些实验的结果可能会提供重要的新的 缺血性心脏病室性心律失常机制的研究进展 心脏病，也可以提高识别患者， 面临这些致命室性心律失常的风险。