RADIONUCLIDE IMAGING USING I 125 MIBG IN NEWBORN HEARTS

大鼠心肌交感神经发育变化的研究 出生后，局部交感神经支配会发生变化， 暂时导致部分无神经支配。交感神经的增加 音调可能在部分无神经支配的脑室上不均匀地传递， 这可能会导致危及生命的脑室风险增加 心律不齐。我们建议标测心肌交感神经的分布。 新生动物的神经末梢，用I-125间碘苯甲基胍 (MIBG)和~(99m)Tc心肌灌注的分布 Sestamibi，使用定量放射自显影和参数图像。我们 将闪烁照相结果与形态密度相关联 交感神经和肌细胞缝隙连接；以及高密度 心肌复极的电生理图谱。我们还将 研究复极的空间弥散的变化如何提供 异质神经支配环境下心律失常的底物 使用计算机模拟，增加了共鸣的语气。这些研究可能 提高对不明原因突发性疾病发病机制的认识 婴儿死亡综合征(SLDs)，婴儿死亡的主要原因 超过一岁，并可能允许对婴儿进行无创检测 风险。

Developmental changes in myocardial sympathetic nerves during the postnatal period produce alterations in regional sympathetic innervation, transiently leading to partial noninnervation. Increases in sympathetic tone may be delivered unevenly over the partially noninnervated ventricle, which may lead to an increased risk of life threatening ventricular arrhythmia. We propose to map the distribution of myocardial sympathetic nerve endings in newborn animals, with I-125 metaiodobenzylguanidine (MIBG), and the distribution of myocardial perfusion with Tc-99m sestamibi, using quantitative autoradiography, and parametric images. We will correlate scintigraphic results with morphologic density of sympathetic nerves and myocyte gap junctions; along with high density electrophysiologic maps of myocardial repolarization. We will also examine how changes in spatial dispersion of repolarization provides the substrate for arrhythmias in the setting of heterogeneous innervation and increased sympathetic tone, using computer modelling. These studies may improve the understanding of mechanisms relating to unexplained sudden infant death syndrome (SlDS), the leading cause of death in infants less than one year old, and may allow non invasive detection of infants at risk.